Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury

Magnetic Resonance in Medicine

Volumn 58, Issue 2, 2007, Pages 253-260

  Joong, Hee Kim ^a   Loy, David N ^a   Liang, Hsiao Fang ^a   Trinkaus, Kathryn ^b   Schmidt, Robert E ^b   Song, Sheng Kwei ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anisotropy; Axial; Contusion; Diffusion tensor imaging; Locomotion; Magnetic resonance; Mouse; Radial; Spinal cord injury

Indexed keywords

ANISOTROPY; BIPED LOCOMOTION; CLUSTERING ALGORITHMS; DIFFUSION; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; MAMMALS; PATIENT REHABILITATION; RADIOLOGY; TENSORS;

AXIAL; CONTUSION; MOUSE; RADIAL; SPINAL CORD INJURIES (SCI);

DIFFUSION TENSOR IMAGING;

MYELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANISOTROPY; ARTICLE; BRAIN MAPPING; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; FEMALE; GRAY MATTER; HISTOLOGY; IN VIVO STUDY; MEASUREMENT; MOUSE; NERVE FIBER; NONHUMAN; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SPINAL CORD INJURY; WHITE MATTER;

EID: 34547944779     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21316     Document Type: Article

References (38)

1. Ma M, Basso DM, Walters P, Stokes BT, Jakeman LB. Behavioral and histological outcomes following graded spinal cord contusion injury in the C57B1/6 mouse. Exp Neurol 2001;169:239-254.
2. Loy DN, Magnuson DS, Zhang YP, Onifer SM, Mills MD, Cao QL, Darnall JB, Fajardo LC, Burke DA, Whittemore SR. Functional redundancy of ventral spinal locomotor pathways. J Neurosci 2002;22:315-323.
3. Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996;139:244-256.
4. Behrmann DL, Bresnahan JC, Beattie MS. Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methyl-prednisolone, U-74006F and YM-14673. Exp Neurol 1994;126:61-75.
5. Cao Q, Xu XM, Devries WH, Enzmann GU, Ping P, Tsoulfas P, Wood PM, Bunge MB, Whittemore SR. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci 2005;25:6947-6957.
6. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 2001;13:534-546.
7. Basser PJ, Jones DK. Diffusion-tensor MRI: theory, experimental design and data analysis - a technical review. NMR Biomed 2002;15:456-467.
8. Sotak CH. The role of diffusion tensor imaging in the evaluation of ischemic brain injury - a review. NMR Biomed 2002;15:561-569.
9. Sundgren PC, Dong Q, Gomez-Hassan D, Mukherji SK, Maly P, Welsh R. Diffusion tensor imaging of the brain: review of clinical applications. Neuroradiology 2004;46:339-350.
10. Sarntinoranont M, Chen X, Zhao J, Mareci TH. Computational model of interstitial transport in the spinal cord using diffusion tensor imaging. Ann Biomed Eng 2006;34:1304-1321.
11. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17:1429-1436.
12. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage 2003;20:1714-1722.
13. Kim JH, Budde MD, Liang HF, Klein RS, Russell JH, Cross AH, Song SK. Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiol Dis 2006;21:626-632.
14. Schwartz ED, Hackney DB. Diffusion-weighted MRI and the evaluation of spinal cord axonal integrity following injury and treatment. Exp Neurol 2003;184:570-589.
15. Bilgen M, Elshafiey I, Narayana PA. In vivo magnetic resonance microscopy of rat spinal cord at 7 T using implantable RF coils. Magn Reson Med 2001;46:1250-1253.
16. Deo AA, Grill RJ, Hasan KM, Narayana PA. In vivo serial diffusion tensor imaging of experimental spinal cord injury. J Neurosci Res 2006;83:801-810.
17. Madi S, Hasan KM, Narayana PA. Diffusion tensor imaging of in vivo and excised rat spinal cord at 7 T with an icosahedral encoding scheme. Magn Reson Med 2005;53:118-125.
18. Bilgen M, Al-Hafez B, Berman NE, Festoff BW. Magnetic resonance imaging of mouse spinal cord. Magn Reson Med 2005;54:1226-1231.
19. Bonny JM, Gaviria M, Donnat JP, Jean B, Privat A, Renou JP. Nuclear magnetic resonance microimaging of mouse spinal cord in vivo. Neurobiol Dis 2004;15:474-482.
20. Jakeman LB, Guan Z, Wei P, Ponnappan R, Dzwonczyk R, Popovich PC, Stokes BT. Traumatic spinal cord injury produced by controlled contusion in mouse. J Neurotrauma 2000;17:299-319.
21. Bilgen M. Magnetic resonance microscopy of spinal cord injury in mouse using a miniaturized implantable RF coil. J Neurosci Methods 2007;159:93-97.
22. Garbow J DJ, Song S-K, Conradi M. A simple, robust hardware device for passive or active respiratory gating in MRI and MRS experiments. Concepts Magn Reson Part B Magn Reson Eng 2004;21B:40-48.
23. Kim JH, Trinkaus K, Ozcan A, Budde MD, Song SK. Postmortem delay does not change regional diffusion anisotropy characteristics in mouse spinal cord white matter. NMR Biomed 2007; 20:352-359.
24. Stejskal ET, JE. Spin echoes in the presence of a time-dependent field gradient. J Chem Phys 1965;42:288-292.
25. Sun SW, Liang HF, Le TQ, Armstrong RC, Cross AH, Song SK. Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia. Neuroimage 2006;32:1195-1204.
26. Edelstein WA, Bottomley PA, Pfeifer LM. A signal-to-noise calibration procedure for NMR imaging systems. Med Phys 1984;11:180-185.
27. Waxman SG. Demyelination in spinal cord injury. J Neurol Sci 1989;91:1-14.
28. Norenberg MD, Smith J, Marcillo A. The pathology of human spinal cord injury: defining the problems. J Neurotrauma 2004;21:429-440.
29. Song SK, Yoshino J, Le TQ, Lin SJ, Sun SW, Cross AH, Armstrong RC. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005;26:132-140.
30. Popovich PG, Horner PJ, Mullin BB, Stokes BT. A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Exp Neurol 1996;142:258-275.
31. Wallace MC, Tator CH. Spinal cord blood flow measured with microspheres following spinal cord injury in the rat. Can J Neurol Sci 1986;13:91-96.
32. Ditunno JF, Little JW, Tessler A, Burns AS. Spinal shock revisited: a four-phase model. Spinal Cord 2004;42:383-395.
33. Brustein E, Rossignol S. Recovery of locomotion after ventral and ventrolateral spinal lesions in the cat. I. Deficits and adaptive mechanisms. J Neurophysiol 1998;80:1245-1267.
34. Ditunno Jr JF, Burns AS, Marino RJ. Neurological and functional capacity outcome measures: essential to spinal cord injury clinical trials. J Rehabil Res Dev 2005;42:35-41.
35. Totoiu MO, Keirstead HS. Spinal cord injury is accompanied by chronic progressive demyelination. J Comp Neurol 2005;486:373-383.
36. Wimberger DM, Roberts TP, Barkovich AJ, Prayer LM, Moseley ME, Kucharczyk J. Identification of "premyelination" by diffusion-weighted MRI. J Comput Assist Tomogr 1995;19:28-33.
37. Prayer D, Barkovich AJ, Kirschner DA, Prayer LM, Roberts TP, Kucharczyk J, Moseley ME. Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy. AJNR Am J Neuroradiol 2001;22:1572-1576.
38. Drobyshevsky A, Song SK, Gamkrelidze G, Wyrwicz AM, Derrick M, Meng F, Li L, Ji X, Trommer B, Beardsley DJ, Luo NL, Back SA, Tan S. Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential. J Neurosci 2005;25:5988-5997.