Neurovascular and hemodynamic responses to hyperinsulinemia in healthy postmenopausal women

Maturitas

Volumn 58, Issue 1, 2007, Pages 50-58

  Cardoso Jr , Crivaldo Gomes ^a   Sakai, Daniela ^a   Pinto, Luiz Gustavo ^a   Labes, Eliana ^a   de Gusmão, Josiane Lima ^a   Abrahão, Sandra Balieiro ^a   Tinucci, Taís ^a   Mion Jr , Décio ^a   Fonseca, Angela Maggio da ^a   Forjaz, Cláudia Lúcia de Moraes ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Blood pressure; Hyperinsulinemia; Menopause; Muscle blood flow; Spectral analysis; Sympathetic activity

Indexed keywords

ADRENALIN; GLUCOSE; INSULIN; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ADRENERGIC SYSTEM; ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; CARBOHYDRATE INTAKE; CARDIOVASCULAR EFFECT; DIETARY INTAKE; ELECTROCARDIOGRAM; FEMALE; FOREARM BLOOD FLOW; GLUCOSE BLOOD LEVEL; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN INFUSION; MENOPAUSE; MUSCLE BLOOD FLOW; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; POSTMENOPAUSE; VASODILATATION;

BLOOD FLOW VELOCITY; BLOOD GLUCOSE; EPINEPHRINE; FEMALE; GLUCOSE CLAMP TECHNIQUE; HEMODYNAMICS; HUMANS; HYPERINSULINISM; INSULIN; MIDDLE AGED; NOREPINEPHRINE; POSTMENOPAUSE; REFERENCE VALUES;

EID: 34547938284     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2007.05.001     Document Type: Article

References (41)

1. Scott E.M., Greenwood J.P., Vacca G., Stoker J.B., Gilbey S.G., and Mary D.A. Carbohydrate ingestion, with transient endogenous insulinaemia, produces both sympathetic activation and vasodilatation in normal humans. Clin Sci (London) 5 (2002) 523-529
2. van Gurp P.J., Rongen G.A., Lenders J.W., Al Nabawy A.K., Timmers H.J., and Tack C.J. Sustained hyperglycaemia increases muscle blood flow but does not affect sympathetic activity in resting humans. Eur J Appl Physiol 5/6 (2005) 648-654
3. Vollenweider P., Tappy L., Randin D., et al. Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. J Clin Invest 1 (1993) 147-154
4. Bisquolo V.A., Cardoso Jr. C.G., Ortega K.C., et al. Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia. J Appl Physiol 3 (2005) 866-871
5. Forjaz C.L., Ramires P.R., Tinucci T., et al. Postexercise responses of muscle sympathetic nerve activity and blood flow to hyperinsulinemia in humans. J Appl Physiol 2 (1999) 824-829
6. Vollenweider P., Randin D., Tappy L., Jequier E., Nicod P., and Scherrer U. Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. J Clin Invest 6 (1994) 2365-2371
7. Vollenweider L., Tappy L., Owlya R., Jequier E., Nicod P., and Scherrer U. Insulin-induced sympathetic activation and vasodilation in skeletal muscle. Effects of insulin resistance in lean subjects. Diabetes 6 (1995) 641-645
8. Anderson E.A., Hoffman R.P., Balon T.W., Sinkey C.A., and Mark A.L. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 6 (1991) 2246-2252
9. Hausberg M., Mark A.L., Hoffman R.P., Sinkey C.A., and Anderson E.A. Dissociation of sympathoexcitatory and vasodilator actions of modestly elevated plasma insulin levels. J Hypertens 9 (1995) 1015-1021
10. Hausberg M., Sinkey C.A., Mark A.L., Hoffman R.P., and Anderson E.A. Sympathetic nerve activity and insulin sensitivity in normotensive offspring of hypertensive parents. Am J Hypertens 11 (1998) 1312-1320 Pt 1
11. Berne C., Fagius J., Pollare T., and Hjemdahl P. The sympathetic response to euglycaemic hyperinsulinaemia. Evidence from microelectrode nerve recordings in healthy subjects. Diabetologia 9 (1992) 873-879
12. Baron A.D., and Brechtel G. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol 1 Pt 1 (1993) E61-E67
13. Arauz-Pacheco C., Lender D., Snell P.G., et al. Relationship between insulin sensitivity, hyperinsulinemia, and insulin-mediated sympathetic activation in normotensive and hypertensive subjects. Am J Hypertens 12 Pt 1 (1996) 1172-1178
14. Minaker K.L., Rowe J.W., Young J.B., Sparrow D., Pallotta J.A., and Landsberg L. Effect of age on insulin stimulation of sympathetic nervous system activity in man. Metabolism 12 (1982) 1181-1184
15. Muscelli E., Emdin M., Natali A., et al. Autonomic and hemodynamic responses to insulin in lean and obese humans. J Clin Endocrinol Metab 6 (1998) 2084-2090
16. Paolisso G., Manzella D., Tagliamonte M.R., Rizzo M.R., Gambardella A., and Varricchio M. Effects of different insulin infusion rates on heart rate variability in lean and obese subjects. Metabolism 6 (1999) 755-762
17. Bergholm R., Westerbacka J., Vehkavaara S., Seppala-Lindroos A., Goto T., and Yki-Jarvinen H. Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects. J Clin Endocrinol Metab 3 (2001) 1403-1409
18. Baron A.D., Steinberg H.O., Chaker H., Leaming R., Johnson A., and Brechtel G. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J Clin Invest 2 (1995) 786-792
19. Dela F., Stallknecht B., and Biering-Sorensen F. An intact central nervous system is not necessary for insulin-mediated increases in leg blood flow in humans. Pflugers Arch 2/3 (2000) 241-250
20. Lind L., Fugmann A., Millgard J., Berne C., and Lithell H. Insulin-mediated vasodilatation, but not glucose uptake or endothelium-mediated vasodilatation, is enhanced in young females compared with males. Clin Sci (London) 2 (2002) 241-246
21. Baron A.D., Tarshoby M., Hook G., et al. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 5 (2000) 768-774
22. Hoffman R.P., Sinkey C.A., Dopp J.M., and Phillips B.G. Lack of effect of alpha- and beta-adrenergic inhibition on forearm glucose uptake despite differences in forearm blood flow in healthy humans. Metabolism 11 (2002) 1506-1513
23. Berne C., Fagius J., and Niklasson F. Sympathetic response to oral carbohydrate administration. Evidence from microelectrode nerve recordings. J Clin Invest 5 (1989) 1403-1409
24. Walton C., Godsland I.F., Proudler A.J., Wynn V., and Stevenson J.C. The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women. Eur J Clin Invest 8 (1993) 466-473
25. Toth M.J., Sites C.K., Eltabbakh G.H., and Poehlman E.T. Effect of menopausal status on insulin-stimulated glucose disposal: comparison of middle-aged premenopausal and early postmenopausal women. Diab Care 6 (2000) 801-806
26. Vongpatanasin W., Tuncel M., Mansour Y., Arbique D., and Victor R.G. Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women. Circulation 24 (2001) 2903-2908
27. Liu C.C., Kuo T.B., and Yang C.C. Effects of estrogen on gender-related autonomic differences in humans. Am J Physiol Heart Circ Physiol 5 (2003) H2188-H2193
28. Narkiewicz K., Phillips B.G., Kato M., Hering D., Bieniaszewski L., and Somers V.K. Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 4 (2005) 522-525
29. Moreau K.L., Donato A.J., Tanaka H., Jones P.P., Gates P.E., and Seals D.R. Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J Physiol (2003) 309-316 Pt 1
30. Vehkavaara S., Westerbacka J., Hakala-Ala-Pietila T., Virkamaki A., Hovatta O., and Yki-Jarvinen H. Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women. J Clin Endocrinol Metab 12 (2000) 4663-4670
31. Anderson E.A. Measurement of blood flow and venous distensibility. In: Schneiderman N., Weiss S.M., and Kauffman P.G. (Eds). Handbook of reserarch methods and cardiovacular behavioral medicine (1989), Plenum Publishing Corporation, New York
32. Siggaard-Andersen J. Venous occlusion plethysmography on the calf. Evaluation of diagnosis and results in vascular surgery. Dan Med Bull (1970) 1-68 Suppl I
33. Task TFotESoCatNASoPaE. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 5: 1043-65.
34. Malliani A., Pagani M., Lombardi F., and Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 2 (1991) 482-492
35. DeFronzo R.A., Tobin J.D., and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 3 (1979) E214-E223
36. Grassi G., and Esler M. How to assess sympathetic activity in humans. J Hypertens 6 (1999) 719-734
37. Pagani M., Montano N., Porta A., et al. Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 6 (1997) 1441-1448
38. Malliani A., Pagani M., and Lombardi F. Physiology and clinical implications of variability of cardiovascular parameters with focus on heart rate and blood pressure. Am J Cardiol 10 (1994) 3C-9C
39. Muntzel M.S., Malena H., and Drueke T. Inhibition of nitric oxide synthesis attenuates insulin-mediated sympathetic activation in rats. J Hypertens 9 (2001) 1625-1631
40. van Veen S., and Chang PC. Prostaglandins and nitric oxide mediate insulin-induced vasodilation in the human forearm. Cardiovasc Res 1 (1997) 223-229
41. Vincent M.A., Barrett E.J., Lindner J.R., Clark M.G., and Rattigan S. Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin. Am J Physiol Endocrinol Metab 1 (2003) E123-E129