Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 12, 2000, Pages 4663-4670

  Vehkavaara, Satu ^a   Westerbacka, Jukka ^a   Hakala Ala Pietilä, Tiina ^c   Virkamäki, Antti ^a,b   Hovatta, Outi ^d   Yki Järvinen, Hannele ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^c Vaestoliitto   (Finland)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; INSULIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ESTROGEN THERAPY; FEMALE; FOREARM BLOOD FLOW; GLUCOSE METABOLISM; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; INSULIN SENSITIVITY; NORMAL HUMAN; PERIPHERAL CIRCULATION; POSTMENOPAUSE; PRIORITY JOURNAL; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; GLUCOSE; HEMODYNAMIC PROCESSES; HUMANS; INSULIN; INSULIN RESISTANCE; MIDDLE AGED; POSTMENOPAUSE; REGIONAL BLOOD FLOW; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; VASCULAR RESISTANCE;

EID: 0034487491     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.12.4663     Document Type: Article

References (82)

1. Hyperinsulinemia and the risk of stroke in healthy middle-aged men: The 22-year follow-up results of the Helsinki Policemen Study
2. Is there a glycemic threshold for mortality risk?
3. Insulin and risk of cardiovascular disease: A meta-analysis
4. Diminished wave reflection in the aorta. A novel physiological action of insulin on large blood vessels
5. Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity
6. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
7. Nitric oxide release accounts for insulin's vascular effects in humans
8. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
9. Estrogen replacement reverses endothelial dysfunction in postmenopausal women
10. Estrogen improves endothelium-dependent, flow-mediated vasodilatation in postmenopausal women
11. Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women
12. Individual and combined effects of estrogen/progestin therapy and lovastatin on lipids and flow-mediated vasodilation in postmenopausal women with coronary artery disease
13. Estrogen therapy combined with progesterone and endothelium-dependent vasodilatation in postmenopausal women
14. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women
15. Hormone replacement therapy in postmenopausal women protects against smoking-induced changes in vascular structure and function
16. Effect of hormone replacement therapy on non-invasive cardiovascular haemodynamics
17. Alteration in the pulsatility index values of the internal carotid and middle cerebral arteries after suspension of postmenopausal hormone replacement therapy: A randomized crossover study
18. Withdrawal of hormonal therapy for 4 weeks decreases arterial compliance in postmenopausal women
19. Hormonal therapy increases arterial compliance in postmenopausal women
20. Sex and insulin sensitivity
21. Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron emission tomography
22. Glucose clamp technique: A method for quantifying insulin secretion and resistance
23. The effect of estradiol and a combined estradiol/progestagen preparation on insulin sensitivity in healthy postmenopausal women
24. A comparison of the effects of oral and transdermal estrogen replacement on insulin sensitivity in postmenopausal women
25. Influence of continuous combined estradiol-norethisterone acetate preparations on insulin sensitivity in postmenopausal nondiabetic women
26. Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM
27. Insulin resistance, secretion, and elimination in postmenopausal women receiving oral or transdermal hormone replacement therapy
28. Estrogen replacement therapy decreases hyperandrogenicity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin-dependent diabetes mellitus
29. The effect of transdermal 17-beta-estradiol on glucose metabolism of postmenopausal women is evident during the oral but not the intravenous glucose administration
30. Effects of low doses of transdermal 17-β-estradiol on cardohydrate metabolism in postmenopausal women
31. The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women
32. A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin
33. Effects of hormone replacement therapy on glucose metabolism
34. Insulin sensitivity during postmenopausal hormone replacement with transdermal estradiol and intra-uterine levonorgestrel
35. Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenons glucose tolerance test
36. Minimization: A new method of assigning patients to treatment and control groups
37. Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects
38. Pulse wave analysis
39. An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man
40. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function
41. Noninvasive determination of age-related changes in the human arterial pulse
42. Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis
43. Non-invasive measurements of arterial structure and function: Repeatability, interrelationships and trial sample size
44. Assessment of fat-free mass using bioelectrical impedance measurements of the human body
45. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassay
46. A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption
47. Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus
48. Analysis of plasma high density lipoprotein subclasses by a precipitation procedure: Correlation with preparative and analytical ultracentrifugation
49. Europium as a label in time-resolved immunofluorometric assays
50. Evaluation of radioimmunoassay for estradiol in unextracted serum
51. Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels
52. Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
53. Impaired forearm blood flow and vasodilator reserve in healthy postmenopausal women
54. Estrogen acutely increases peripheral blood flow in postmenopausal women
55. Effects of endothelium derived nitric oxide on peripheral arterial tone in man
56. Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: The nitric oxide dilator mechanism appears abnormal
57. Effects of estrogen replacement therapy on peripheral vasomotor function in postmenopausal women
58. Effect of prolonged administration of transdermal estradiol on flow-mediated endothelium-dependent and endothelium-independent vasodilation in healthy postmenopausal women
59. A prospective, controlled trial of six forms of hormone replacement therapy given to postmenopausal women
60. The effect of type and dose of oestrogen on the blood pressure of postmenopausal women
61. Blood pressure and hemodynamics in postmenopausal women during estradiol-17β substitution
62. Differing responses in blood pressure over 24 hours in normotensive women receiving oral or transdermal estrogen replacement therapy
63. Blood pressure during oestrogen/progestogen substitution therapy in healthy post-menopausal women
64. Effects of oestrogen and progesterone on age-related changes in arteries of postmenopausal women
65. Age-related deterioration in arterial structure and function in postmenopausal women: Impact of hormone replacement therapy
66. Influence of age and postmenopausal estrogen replacement therapy on carotid arterial stiffness in women
67. Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus
68. Insulin-induced vasodilatation: Physiology or pharmacology?
69. Effect of insulin on acetylcholine-induced vasodilatation in normotensive subjects and patients with essential hypertension
70. Obesity/insulin resistance in associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
71. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women
72. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women
73. 17β-estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease
74. Acute vascular effects of estrogen in postmenopausal women
75. Noninvasive determination of age-related changes in the human arterial pulse
76. Independent influence of age on basal insulin secretion in nondiabetic humans
77. Does aging intensify the insulin resistance of human obesity?
78. The effects of the menopause on insulin sensitivity, secretion and elimination in nonobese, healthy women
79. Insulin sensitivity during the menstrual cycle