Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 18, 2007, Pages 5068-5071

  Liñares, Guadalupe García ^a,b   Gismondi, Santiago ^a   Codesido, Nicolás Osa ^a   Moreno, Silvia N J ^b   Docampo, Roberto ^b   Rodriguez, Juan B ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Aryloxyethyl thiocyanates; Chagas' disease; Squalene synthase; Toxoplasma gondii; Trypanosoma cruzi

Indexed keywords

4 PHENOXYPHENOXYETHYL THIOCYANATE; ANTIPARASITIC AGENT; ATOVAQUONE; FLUORINE; THIOCYANIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WC 9;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHAGAS DISEASE; CHEMICAL REACTION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; TACHYZOITE; TOXOPLASMA GONDII; TOXOPLASMOSIS; TRYPANOSOMA CRUZI;

ANIMALS; DRUG DESIGN; FLUORINE; MAGNETIC RESONANCE SPECTROSCOPY; THIOCYANATES; TOXOPLASMA; TRYPANOSOMA CRUZI;

TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

EID: 34547916413     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.012     Document Type: Article

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