Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii

International Journal of Antimicrobial Agents

Volumn 25, Issue 2, 2005, Pages 130-135

  Dantas Leite, Lucas ^a   Urbina, Julio A ^b   Souza, Wanderley De ^a   Vommaro, Rossiane C ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Apicomplexa; Azasterols; Endodiogeny arrest; Sulphonamides

Indexed keywords

22,26 AZASTEROL 20 PIPERIDIN 2 YL 5ALPHA PREGNAN 3BETA,20 DIOL; 24,25 EPIMINOLANOSTEROL; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; STEROL DERIVATIVE; SULFADIAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; DRUG SELECTIVITY; MAMMAL CELL; MITOCHONDRION SWELLING; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII;

ANIMALS; CELL LINE; CHOLESTANOL; COCCIDIOSTATS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FOLIC ACID ANTAGONISTS; HOST-PARASITE RELATIONS; LANOSTEROL; MACACA MULATTA; PARASITIC SENSITIVITY TESTS; PYRIMETHAMINE; SULFADIAZINE; TOXOPLASMA;

EID: 12344297714     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2004.08.016     Document Type: Article

References (27)

1. R.L. Goldenberg, and C. Thompson The infectious origins of stillbirth Am J Obstet Gynecol 189 2003 861 873
2. L. Mozzatto, and R.S. Procianoy Incidence of congenital toxoplasmosis in southern Brazil: a prospective study Rev Inst Med Trop Sao Paulo 45 2003 147 151
3. B.J. Luft, R.G. Brooks, and F.K. Conley Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome JAMA 252 1984 913 917
4. C. Harris, M.P. Salgo, and H.B. Tanowitz In vitro assessment of antimicrobial agents against Toxoplasma gondii J Infect Dis 1570 1988 14 22
5. J. Alder, T. Hutch, and A. Jonathan Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine J Acquir Immune Defic Syndr 7 1994 1141 1148
6. F. Derouin, and C. Chastang In vitro effects of folate inhibitors on Toxoplasma gondii Antimicrob Agents Chemother 33 1989 1753 1759
7. P.D. Gormley, C.E. Pavesio, and D. Minnasian Effects of drug therapy on Toxoplasma cysts in an animal model of acute and chronic disease Invest Ophthalmol Vis Sci 39 1998 1171 1175
8. L. Dantas-Leite, J.A. Urbina, and W. De Souza Selective antiToxoplasma gondii activities of azasterols Int J Antimicrob Agents 23 2004 620 626
9. 24(25) - sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies Chemotherapy 42 1996 294 307
10. 24(25) - sterol methyltranferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis Antimicrob Agents Chemother 46 2002 487 499
11. 24(25) - sterol methyltranferase block sterol synthesis and cell proliferation in Pneumocystis carinii Antimicrob Agents Chemother 41 1997 1428 1432
12. E.J. Melo, M. Attias, and W. De Souza The single mitochondrion of tachyzoites of Toxoplasma gondii J Struct Biol 130 2000 27 33
13. E.J. Parish, and W.D. Nes Synthesis of new epiminoisopentenoids Synthet Commun 18 1988 221 226
14. J. Huskinson-Mark, F.G. Araujo, and J.S. Remington Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii J Infect Dis 164 1991 170 171
15. M.B. Martin, J.S. Grimley, and J.C. Lewis Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii and Plasmodium falciparum: a potential route to chemotherapy J Med Chem 44 2001 909 916
16. T.C. De Araujo Jorge, and W. De Souza Effect of carbohydrates, periodate and enzymes in the process of endocytosis of Trypanosoma cruzi by macrophages Acta Trop 41 1984 17 28
17. R. Lira, L.M. Contreras, and R. Santa-Rita Mechanism of action of antiproliferative alkyl-lysophospholipids against the protozoan parasite Trypanosoma cruzi. Potentiation of in vitro activity by the sterol biosynthesis inhibitor ketoconazole J Antimicrob Chemother 47 2001 537 546
18. 24(25) - sterol methyl transferase inhibitors and their combinations with ketoconazole Mol Biochem Parasitol 73 1995 199 210
19. H.O. Hallander, K. Dornbush, and L. Gezelius Synergism between aminoglycosides and cephalosporin with antipseudomonal activity: interaction index and killing curve method Antimicrob Agents Chemother 22 1982 743 752
20. N.H. Georgopapadakou, B.A. Dix, and S.A. Smith Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans Antimicrob Agents Chemother 31 1987 46 51
21. A.C. Oehlschlager, R.H. Angus, and A.M. Pierce Azasterol inhibition of delta 24-sterol methyltransferase in Saccharomyces cerevisiae Biochemistry 31 1984 3582 3589
22. J.P. Dubey, D.S. Lindsay, and C. Speer Structures of Toxoplasma gondii tacizoites, bradyzoites and sporozoites and biology and development of tissue cysts Clin Microbiol Rev 11 1998 267 299
23. H.G. Sheffield, and M.L. Melton Effect of pyrimethamine and sulphadiazine on the fine structure and multiplication of Toxoplasma gondii in cell cultures J Parasitol 61 1975 704 712
24. L.M. Contreras, J. Vivas, and J.A. Urbina Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors Biochem Pharmacol 7 1997 697 704
25. 24(25) - sterol methyltranferase inhibitors and their combinations with ketoconazole Int J Antimicrob Agents 7 1996 235 240
26. E. Schoondermark-van de Ven, T. Vree, and W. Melchers In vitro effects of sulphadiazine and its metabolites alone and in combination with pyrimethamine on Toxoplasma gondii Antimicrob Agents Chemother 39 1995 763 765
27. F. Derouin, and M. Santillana-Hayat Antitoxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulphadiazine in vitro Antimicrob Agents Chemother 44 2000 2575 2577