Label-free, single-molecule detection with optical microcavities

Science

Volumn 317, Issue 5839, 2007, Pages 783-787

  Armani, Andrea M ^a   Kulkarni, Rajan P ^b   Fraser, Scott E ^a,b   Flagan, Richard C ^c   Vahala, Kerry J ^a  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; SILICON DIOXIDE;

DETECTION METHOD; EXPERIMENTAL STUDY; OPTICAL METHOD; SENSOR; SERUM; SILICA; WAVELENGTH;

ARTICLE; CHEMICAL BINDING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR SENSOR; OPTICAL ROTATION; PERFORMANCE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES; CATTLE; CHEMISTRY, ANALYTICAL; INTERLEUKIN-2; LASERS; OPTICS; TEMPERATURE;

EID: 34547865680     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1145002     Document Type: Article

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37. We thank O. Painter for useful discussions, B. Min for FEMLAB simulations, N. Pierce for spectrophotometer measurements, and D. Armani for microtoroid fabrication. A.M.A. is supported by the Clare Boothe Luce Postdoctoral Fellowship. This work was supported by the Defense Advanced Research Projects Agency's Center for OptoFluidic Integration and the Biological Imaging Center of the Beckman Institute at the California Institute of Technology.