Human health and endocrine disruption: A simple multicriteria framework for the qualitative assessment of end point-specific risks in a context of scientific uncertainty

Toxicological Sciences

Volumn 98, Issue 2, 2007, Pages 332-347

  Martin, Olwenn V ^a   Lester, John N ^b   Voulvoulis, Nikolaos ^a   Boobis, Alan R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CRANFIELD UNIVERSITY   (United Kingdom)

Author keywords

Endocrine toxicology endocrine disruptors; Risk assessment epidemiology; Risk assessment regulatory policy

Indexed keywords

ENDOCRINE DISRUPTOR;

ARTICLE; CANCER; CANCER RISK; CLINICAL DECISION MAKING; CORRELATION ANALYSIS; DIAGNOSTIC TEST; ENDOCRINE DISEASE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HEALTH HAZARD; HUMAN; IMMUNOTOXICITY; INCIDENCE; INTOXICATION; METHODOLOGY; NEUROTOXICITY; PRACTICE GUIDELINE; QUALITATIVE ANALYSIS; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; RISK FACTOR; TOXIN ANALYSIS;

ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; FEMALE; HUMANS; IMMUNE SYSTEM; MALE; NEOPLASMS; NERVOUS SYSTEM DISEASES; REPRODUCTION; RISK ASSESSMENT; UNCERTAINTY;

EID: 34547851672     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm008     Document Type: Article

References (130)

1. Anderson, L. M. (2004). Introduction and overview. Perinatal carcinogenesis: Growing a node for epidemiology, risk management, and animal studies. Toxicol. Appl. Pharmacol. 199, 85-90.
2. Aravindakshan, J., Gregory, M., Marcogliese, D. J., Fournier, M., and Cyr, D. G. (2004). Consumption of xenoestrogen-contaminated fish during lactation alters adult male reproductive function. Toxicol. Sci. 81, 179-189.
3. Ashby, J. (2001). Testing for endocrine disruption post-EDSTAC: Extrapolation of low dose rodent effects to humans. Toxicol. Lett. 120, 233-242.
4. Axmon, A., Rylander, L., Stromberg, U., Dyremark, E., and Hagmar, L. (2001). Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in-relation to time to pregnancy. J. Toxicol. Environ. Health 64, 485 (Abstract).
5. Axmon, A., Rylander, L., Stromberg, U., and Hagmar, L. (2002). Female fertility in relation to the consumption of fish contaminated with persistent organochlorine compounds. Scand. J. Work Environ. Health 28, 124 (Abstract).
6. Aydin, Z. D. (2005). Sun exposure may confound physical activity-prostate cancer association. Arch. Intern. Med. 165 2538-2539.
7. Azziz, R., Marin, C., Hoq, L., Badamgarav, E., and Song, P. (2005). Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J. Clin. Endocrinol. Metab. 90, 4650-4658.
8. Balasubramaniam, A., and Voulvoulis, N. (2005). The appropriateness of multicriteria analysis in environmental decision-making problems. Environ. Technol. 26, 951-962.
9. Batstone, G., Richard, D., Doble, A., and Batstone, D. (2003). Chronic prostatitis. Curr. Opin. Urol. 13, 23-29.
10. Bellinger, D. C. (2004). Assessing environmental neurotoxicant exposures and child neurobehavior: Confounded by confounding? Epidemiology 15, 383-384.
11. Birkett, J. W., and Lester, J. N. (2003). Endocrine Disrupters in Wastewater and Sludge Treatment Processes. Lewis Publishers/IWA Publishing, London.
12. Birnbaum, L. S., and Cummings, A. M. (2002). Dioxins and endometriosis: A plausible hypothesis. Environ. Health Perspect. 110, 15-21.
13. Blake, C. A., Boockfor, F. R., Nair-Menon, J. U., Millette, C. F., Raychoudhury, S. S., and McCoy, G. L. (2004). Effects of 4-tert-octylphenol given in drinking water for 4 months on the male reproductive system of Fischer 344 rats. Reprod. Toxicol. 18 43-51.
14. Boisen, K. A., Kaleva, M., Main, K. M., Virtanen, H. E., Haavisto, A. M., Schmidt, M., Chellakooty, M., Damgaard, N., Mau, C., Reunanen, M., et al. (2004). Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries. Lancet 363, 1264-1269.
15. Bray, F., Richiardi, L., Ekbom, A., Pukkala, E., Cuninkova, M., and Moller, H. (2006). Trends in testicular cancer incidence and mortality in 22 European countries: Continuing increases in incidence and declines in mortality. Int. J. Cancer 118, 3099-3111.
16. Brinton, L. A., Westhoff, C. L., Scoccia, B., Lamb, E. J., Althuis, M. D., Mabie, J. E., and Moghissi, K. S. (2005). Causes of infertility as predictors of subsequent cancer risk. Epidemiology 16, 500-507.
17. Brody, J. G., and Rudel, R. A. (2003). Environmental pollutants and breast cancer. Environ. Health Perspect. 111, 1007-1019.
18. Calabrese, E. J., and Baldwin, L. A. (2001). Hormesis: U-shaped dose responses and their centrality in toxicology. Trends Pharmacol. Sci. 22, 285-291.
19. Catalano, R., Bruckner, T., Marks, A. R., and Eskenazi, B. (2006). Exogenous shocks to the human sex ratio: The case of September 11, 2001 in New York City. Hum. Reprod. 21, 3127-3131.
20. Catalano, R. A. (2003). Sex ratios in the two Germanies: A test of the economic stress hypothesis. Hum. Reprod. 18, 1972-1975.
21. Chen, C. W. (2001). Assessment of endocrine disruptors: Approaches, issues, and uncertainties. Folia Histochem. Cytobiol. 39, 20-23.
22. Coggon, D., Rose, G., and Barker, D. J. P. (2003). Epidemiology for the Unititiated. BMJ Publishing Group. London.
23. Colborn, T. (2004). Neurodevelopment and endocrine disruption. Environ. Health Perspect. 112, 944-949.
24. Cramer, D. W., and Wise, L. A. (2000). The epidemiology of recurrent pregnancy loss. Semin. Reprod. Med. 18, 331 (Abstract).
25. Dewey, K. G. (2001). Maternal and fetal stress are associated with impaired lactogenesis in humans. J. Nutr. 131, 3012S-3015S.
26. Diamanti-Kandarakis, E., and Piperi, C. (2005). Genetics of polycystic ovary syndrome: Searching for the way out of the labyrinth. Hum. Reprod. Update 11, 631-643.
27. Dietrich, K. N., Eskenazi, B., Schantz, S., Yolton, K., Rauh, V. A., Johnson, C. B., Alkon, A., Canfield, R. L., Pessah, I. N., and Berman, R. F. (2005). Principles and practices of neurodevelopmental assessment in children: Lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environ. Health Perspect. 113, 1437-1446.
28. Duty, S. M., Silva, M. J., Barr, D. B., Brock, J. W., Ryan, L., Chen, Z. Y., Herrick, R. F., Christiani, D. C., and Hauser, R. (2003). Phthalate exposure and human semen parameters. Epidemiology 14, 269-277.
29. Edwards, T. M., Moore, B. C., and Guillette, L. J. (2006). Reproductive dysgenesis in wildlife: A comparative view. Int. J. Androlog. 29, 109-121.
30. European Environment Agency (EEA) (2001). Late lessons from early warnings: The precautionary principle 1896-2000. European Environment Agency, Copenhagen.
31. Egozcue, J., Blanco, J., Anton, E., Egozcue, S., Sarrate, Z., and Vidal, F. (2003). Genetic analysis of sperm and implications of severe male infertility - A review. Placenta 24(Suppl 2), S62-S65.
32. Faust, M., Altenburger, R., Backhaus, T., Blanck, H., Boedeker, W., Gramatica, P., Hamer, V., Scholze, M., Vighi, M., and Grimme, L. H. (2003). Joint algal toxicity of 16 dissimilarly acting chemicals is predictable by the concept of independent action. Aquat. Tox. 63, 43-63.
33. Ferguson, S. A., Flynn, K. M., Delclos, K. B., Newbold, R. R., and Gough, B. J. (2002). Effects of lifelong dietary exposure to genistein or nonylphenol on amphetamine-stimulated striatal dopamine release in male and female rats. Neurotoxicol. Teratol. 24, 37-45.
34. Fisher, J. S. (2004). Environmental anti-androgens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome. Reproduction 127, 305-315.
35. Friederichs, V., Cameron, J. C., and Robertson, C. (2006). Impact of adverse publicity on MMR vaccine uptake: A population based analysis of vaccine uptake records for one million children, born 1987-2004. Arch. Dis. Child. 91, 465-468.
36. Funabashi, T., Sano, A., Mitsushima, D., and Kimura, F. (2003). Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats. J. Neuroendocrinol. 15, 134-140.
37. Gee, D. (2006). Late lessons from early warnings: Toward realism and precaution with endocrine-disrupting substances. Environ. Health Perspect. 114, 152-160.
38. Giwercman, A., Rylander, L., Hagmar, L., and Giwercman, Y. L. (2006). Ethnic differences in occurrence of TDS - Genetics and/or environment? Int. J. Androl. 29, 291-297.
39. Gray, K. A., Klebanoff, M. A., Brock, J. W., Zhou, H., Darden, R., Needham, L., and Longnecker, M. P. (2005). In utero exposure to background levels of polychlorinated biphenyls and cognitive functioning among school-age children. Am. J. Epidemiol. 162, 17-26.
40. Grover, P. L., and Martin, F. L. (2002). The initiation of breast and prostate cancer. Carcinogenesis 23, 1095-1102.
41. Gundert-Remy, U., Kremers, P., Renwick, A., Kopp-Schneider, A., Dahl, S. G., Boobis, A., Oberemm, A., and Pelkonen, O. (2005). Molecular approaches to the identification of biomarkers of exposure and effect - Report of an expert meeting organized by COST action B15. November 28, 2003. Toxicol. Lett. 156, 227-240.
42. Habermacher, G. M., Chason, J. T., and Schaeffer, A. J. (2006). Prostatitis/chronic pelvic pain syndrome. Annu. Rev. Med. 57 195-206.
43. Hanke, W., and Jurewicz, J. (2004). The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: An overview of current epidemiological evidence. Int. J. Occup. Med. Environ. Health 17, 223 (Abstract).
44. Hart, R., Hickey, M., and Franks, S. (2004). Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract. Res. Clin. Obstet. Gynaecol. 18, 671-683.
45. Heilier, J. -F., Nackers, F., Verougstraete, V., Tonglet, R., Lison, D., and Donnez, J. (2005). Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules. Fertil. Steril. 84, 305-312.
46. Hemminki, K., and Chen, B. (2006). Familial risks in testicular cancer as aetiological clues. Int. J. Androl. 29, 205-210.
47. Hertz-Picciotto, I. (1998) Environmental Epidemiology. In Modern Epidemiology. Rothman, K. J. and Greenland, S. (eds), 2nd ed. pp.555-583. Lippincott-Raven Publishers, Philadelphia.
48. Hill, A. B. (1965). The environment and disease: Association or causation? Proc. R. Soc. Med. 58, 295-300.
49. Hogan, M. D., Newbold, R. R., and McLachlan, J. A. (1987). Extrapolation of Teratogenic Responses Observed in Laboratory Animals to Humans. Branbury Report 26: Development Toxicology: Mechanisms and Risk Cold Spring Harbor Laboratory, New York.
50. International Programme on Chemical Safety (2002). Global Assessment of the State-of-the-Science of Endocrine Disruptors. World Health Organisation, Geneva, Switzerland. 180 p.
51. International Programme on Chemical Safety (2006). Coordinator's Report on IPCS Progress and Activities - June 2004 to December 2005. WHO, Geneva, Switzerland. p. 29.
52. James, W. H. (2006). Offspring sex ratios at birth as markers of paternal endocrine disruption. Environ. Res. 100, 77-85.
53. Jensen, T. K., Andersson, A. -M., Jorgensen, N., Andersen, A. -G., Carlsen, E., Petersen, J. o. H., and Skakkebaek, N. E. (2004). Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil. Steril. 82, 863-870.
54. Kabesch, M. (2006). Gene by environment interactions and the development of asthma and allergy. Toxicol. Lett. 162, 43-48.
55. Karmaus, W., Davis, S., Fussman, C., and Brooks, K. (2005). Maternal concentration of dichlorodiphenyl dichloroethylene (DDE) and initiation and duration of breast feeding. Paediatr. Perinat. Epidemiol. 19, 388-398.
56. Kopp, H. G., Kuczyk, M., Classen, J., Stenzl, A., Kanz, L., Mayer, F., Bamberg, M., and Hartmann, J. T. (2006). Advances in the treatment of testicular cancer. Drugs 66, 641 (Abstract).
57. Kort, H. I., Massey, J. B., Elsner, C. W., Mitchell-Leef, D., Shapiro, D. B., Witt, M. A., and Roudebush, W. E. (2006). Impact of body mass index values on sperm quantity and quality. J. Androl. 27, 450-452.
58. Landrigan, P., Garg, A., and Droller, D. B. J. (2003). Assessing the effects of endocrine disruptors in the National Children's Study. Environ. Health Perspect. 111, 1678-1682.
59. Laviola, G., Gioiosa, L., Adriani, W., and Palanza, P. (2005). D-amphetamine-related reinforcing effects are reduced in mice exposed prenatally to estrogenic endocrine disruptors. Brain Res. Bull. 65, 235-240.
60. Leenhardt, L., Grosclaude, P., and Chérié-Challine, L. (2004). Increased incidence of thyroid carcinoma in France: A true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. Thyroid 14, 1056-1060.
61. Le Gales, C., and Moatti, J. P. (1990). Searching for consensus through multi-criteria decision analysis. Assessment of screening strategies for hemoglo-binopathies in southeastern France. Int. J. Technol. Assess. Health Care 6, 430 (Abstract).
62. Lovelady, C. A. (2005). Is maternal obesity a cause of poor lactation performance. Nutr. Rev. 63, 352 (Abstract).
63. Markaverich, B., Mani, S., Alejandro, M. A., Mitchell, A., Markaverich, D., Brown, T., Velez-Trippe, C., Murchison, C., O'Malley, B., and Faith, R. (2002). A novel endocrine-disrupting agent in corn with mitogenic activity in human breast and prostatic cancer cells. Environ. Health Perspect. 110, 169-177.
64. Marks, G. B. (2006). Environmental factors and gene-environment interactions in the aetiology of asthma. Clin. Exp. Pharmacol. Physiol. 33, 285-289.
65. Martin, O. V., Lai, K. M., Scrimshaw, M. D., and Lester, J. N. (2005). Receiver operating characteristic analysis for environmental diagnosis. A potential application to endocrine disruptor screening: In vitro estrogenicity bioassays. Environ. Sci. Technol. 39, 5349-5355.
66. Massart, F., Harrell, J. C., Federico, G., and Saggese, G. (2005a). Human breast milk and xenoestrogen exposure: A possible impact on human health. J. Perinatol. 25, 282-288.
67. Massart, F., Seppia, P., Pardi, D., Lucchesi, S., Meossi, C., Gagliardi, L., Liguori, R., Fiore, L., Federico, G., and Saggese, G. (2005b). High incidence of central precocious puberty in a bounded geographic area of northwest Tuscany: An estrogen disrupter epidemic? Gynaecol. Endocrinol. 20, 92-98.
68. Masuo, Y., Morita, M., Oka, S., and Ishido, M. (2004). Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: A study inspired by the physiological roles of PACAP in the brain. Regal. Pept. 123, 225-234.
69. McGuinness, B. M., Buck, G. M., Mendola, P., Sever, L. E., and Vena, J. E. (2001). Infecundity and consumption of polychlorinated biphenyl-contaminated fish. Arch. Environ. Health 56, 250-253.
70. Morgenstern, H. (1982). Uses of ecologic analysis in epidemiologic research. Am. J. Public Health 72, 1336-1344.
71. Nagataki, S., and Nyström, E. (2002). Epidemiology and primary prevention of thyroid cancer. Thyroid 12, 889-896.
72. Newbold, R. R., Hanson, R. B., Jefferson, W. N., Bullock, B. C., Haseman, J., and McLachlan, J. A. (1998). Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 19, 1655-1663.
73. Newbold, R. R., Hanson, R. B., Jefferson, W. N., Bullock, B. C., Haseman, J., and McLachlan, J. A. (2000). Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethyl-stilbestrol. Carcinogenesis 21, 1355-1363.
74. Nickel, J. C., Downey, J., Hunter, D., and Clark, J. (2001). Prevalence of prostastitis-like symptoms in a population based study using the national institutes of health chronic prostatitis symptom index. J. Urol. 165, 842-845.
75. Onn Wong, K., Woon Leo, L., and Leng Seah, H. (2005). Dietary exposure assessment of infants to bisphenol A from the use of polycarbonate baby milk bottles. Food Addit. Contamin. 22, 280-288.
76. Owens, W., and Koeter, H. B. W. M. (2003). The OECD program to validate the rat uterotrophic bioassay: An overview. Environ. Health Perspect. 111, 1527-1529.
77. Ozaki, A., Yamaguchi, Y., Okamoto, A., and Kawai, N. (2002). Determination of alkylphenols, bisphenol A, benzophenone and phthalates in containers of baby food, and migration into, food simulants. Shokuhin Eiseigaku Zasshi 43, 260 (Abstract).
78. Palapattu, G. S., Sutcliffe, S., Bastian, P. J., Plaiz, E. A., De Marzo, A. M., Isaacs, W. B., and Nelson, W. G. (2004)., Prostate carcinogenesis and inflammation: Emerging insights. Carcinogenesis 26, 1170-1181.
79. Palmer, J. R., Hartge, P., Noller, K. L., Kaufman, R. H., Hatch, E. E., Rosenberg, C. L., Rao, R. S., Titus-Ernstoff, L., and Herbst, A. L. (2002). Risk of breast cancer in women exposed to diethylstilbestrol in utero: Preliminary results (United States). Cancer Causes Control 13, 753-758.
80. Parent, A. S., Teilmann, G., Juul, A., Skakkebaek, N. E., Toppari, J., and Bourguignon, J. P. (2003). The timing of normal puberty and the age limits of sexual precocity: Variations around the world, secular trends, and changes after migration. Endocr. Rev. 24, 668-693.
81. Partsch, C. J., and Sippell, W. G. (2001). Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens. Hum. Reprod. Update 7, 292-302.
82. Patisaul, H. B. (2005). Phytoestrogen action in the adult and developing brain. J. Neuroendocrinol. 17, 57-64.
83. Pearce, N., and Douwes, J. (2006). The global epidemiology of asthma in children. Int. J. Tuberc. Lung Dis. 10, 125 (Abstract).
84. Pillay, O. C., Te Fong, L. F. W., Crow, J. C., Benjamin, E., Mould, T., Atiomo, W., Menon, P. A., Leonard, A. J., and Hardiman, P. (2006). The association between polycystic ovaries and endometrial cancer. Hum. Reprod. 21, 924-929.
85. Pocock, S. J., Geller, N. L., and Tsiatis, A. A. (1987). The analysis of multiple endpoints in clinical trials. Biometrics 43, 487-498.
86. Porpora, M. G., Ingelido, A. M., Domenico, A. d., Ferro, A., Crobu, M., Pallante, D., Cardelli, M., Cosmi, E. V., and De Felip, E. (2006). Increased levels of polychlorobiphenyls in Italian women with endometriosis. Chemosphere 63, 1361-1367.
87. Poulos, L. M., Toelle, B. G., and Marks, G. B. (2005). The burden of asthma in children: An Australian perspective. Paediatr. Respir Rev. 6, 20-27.
88. Purdue, M. P., Devesa, S. S., Sigurdson, A. J., and McGlynn, K. A. (2005). International patterns and trends in testis cancer incidence. Int. J. Cancer 115, 822-827.
89. Remontet, L., Esteve, J., Bouvier, A. -M., Grosclaude, P., Launoy, G., Menegoz, F., Exbrayat, C., Tretare, B., Carli, P. -M., Guizard, A. -V., et al. (2003). Cancer incidence and mortality in France over the period 1978-2000. Rev. Epidemiol. Sante Publique 51, 3 (Abstract).
90. Reynolds, P., Hurley, S. E., Goldberg, D. E., Yerabati, S., Gunier, R. B., Hertz, A., Anton-Culver, H., Bernstein, L., Deapen, D., Horn-Ross, P. L., et al. (2004). Residential proximity to agricultural pesticide use and incidence of breast cancer in the California Teachers Study cohort. Environ. Res. 96, 206-218.
91. Richiardi, L., Bellocco, R., Adami, H. -O., Torrång, A., Barlow, L., Hakulinen, T., Rahu, M., Stengrevics, A., Storm, H., Tretli, S., et al. (2004). Testicular cancer incidence in eight northern European countries: Secular and recent trends. Cancer Epidemiol. Biomark. Prev. 13, 2157-2166.
92. Ritchie, J. M., Vial, S. L., Fuortes, L. J., Robertson, L. W., Gun, H., Reedy, V. E., and Smith, E. M. (2005). Comparison of proposed frameworks for grouping polychlorinated biphenyl congener data applied to a case-control pilot study of prostate cancer. Environ. Res. 98 104-113.
93. Ronchetti, R., Villa, M. P., and Barreto, M. (2004). L'asma in eta pediatrica. Minerva Pediatr. 56, 133 (Abstract).
94. Rozzi, C. C., Benassi, L. L., Parazzini, F. F., Chatenoud, L. L., La Vecchia, C. C., and Benzi, G. G. (2000). Trends of spontaneous abortions in Italy 1990-1995. Epidemiol. 11, 229-230.
95. Rushton, L. (2000). Reporting of occupational and environmental research: Use and misuse of statistical and epidemiological methods. Occup. Environ. Med. 57, 1-9.
96. Safe, S. (2005). Clinical correlates of environmental endocrine disruptors. Trends Endocrinol. Metab. 16, 139-144.
97. Sakoda, L. C., and Horn-Ross, P. L. (2002). Reproductive and menstrual history and papillary thyroid cancer risk: The San Francisco Bay Area thyroid cancer study. Cancer Epidemiol. Biomark. Prev. 11, 51-57.
98. Salama, J., Chakraborty, T. R., Ng, L., and Gore, A. C. (2003). Effects of polychlorinated biphenyls on estrogen receptor-beta expression in the anteroventral periventricular nucleus. Environ, Health Perspect. 111, 1278-1282.
99. Sallmén, M., Weinberg, C. R., Baird, D. D., Lindbohni, M. -L., and Wilcox, A. J. (2005). Has human fertility declined over time?: Why we may never know. Epidemiology 16, 494-499.
100. Sasco, A. J. (2003). Breast cancer and the environment. Horm Res. 60, 50.
101. Schaeffer, A. J. (2003). Epidemiology and demographics of prostatitis. Andrologia 35, 252-257.
102. Schaeffer, A. J., Alexander, R. B., Nadler, R. B., Propert, K. J., Nickel, J. C., Landis, J. R., Knauss, J. S., Litwin, M. S., and O'Leary, M. P. (2002). Demographic and clinical characteristics of men with chronic prostatitis:THe national institutes of health chronic prostatitis cohort study. J. Urol. 168, 593-598.
103. Schantz, S. L., Widholm, J. J., and Rice, D. C. (2003). Effects of PCB exposure on neuropsychological function in children. Environ. Health Perspect. 111, 357-576.
104. Schwartz, G. G. (2002). Hypothesis: Does ochratoxin A cause testicular cancer? Cancer Causes Control 13, 91-100.
105. Seery, J. P. (2006). Endometriosis associated with defective handling of apoptotic cells in the female genital tract is a major cause of autoimmune disease in women. Med. Hypotheses 66, 945-949.
106. Sell, J., and Scholz, R. W. (2003). Consensus building and knowledge integration methods applied to technology implementation in the Swiss waste incineration industry. Int. J. Environ. Technol. Manag. 3 368 (Abstract).
107. Sharpe, R. M., and Skakkebaek, N. E. (2003). Male reproductive disorders and the role of endocrine disruption: Advances in understanding and identification of areas for future research. Pure Appl. Chem. 75, 2023-2038.
108. Silva, E., Rajapakse, N., and Kortenkamp, A. (2002). Something from "nothing" - Eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ. Sci. Technol. 36, 1751-1756.
109. Sim, H. G., and Cheng, C. W. S. (2005). Changing demography of prostate cancer in Asia. Eur. J. Cancer 41, 834-845.
110. Slama, R., Bouyer, J., Remontet, L., and Spira, A. (2004). Epidemiology of male reproductive function: A field searching for tools. Rev. Epidemiol. Sante Publique 52, 221 (Abstract).
111. Slovic, P. (1987). Perception of risk. 236, 280-285.
112. Spanò, M., Toft, G., Hagmar, L., Eleuteri, P., Rescia, M., Rignell-Hydbom, A., Tyrkiel, E., Zvyezday, V., Bonde, J. P., and INUENDO (2005). Exposure to PCB and p, p'-DDE in European and Inuit populations: Impact on human sperm chromatin integrity. Hum. Reprod. 20, 3488-3499.
113. Steenland, K., and Savitz, D. A. (1997). Topics in Environmental Epidemiology. Oxford University Press, New York.
114. Szpir, M. (2006). New thinking on neurodevelopment. Environ. Health Perspect. 114, A100-A107.
115. Tao, M. H., Xu, W. H., Zheng, W., Gan, Y. T., Ruan, Z. X., Cheng, J. R., Xiang, Y. B., and Shu, X. O. (2005). A case-control study in Shanghai of fruit and vegetable intake and endometrial cancer. Br. J. Cancer 92, 2059-2064.
116. Toft, G., Hagmar, L., Giwercman, A., and Bonde, J. P. (2004). Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reprod. Toxicol. 19, 5-26.
117. Toran-Allerand, C. D., Guan, X., MacLusky, N. J., Horvath, T. L., Diano, S., Singh, M., Connolly, E. S. J., Nethrapalli, I. S., and Tinnikov, A. A. (2002). ER-X: A novel, plasma membrane-associated putative estrogen receptor that is regulated during development and after ischemic brain injury. J. Neurosci. 22, 8391-8401.
118. Tsukino, H., Hanaoka, T., Sasaki, H., Motoyama, H., Hiroshima, M., Tanaka, T., Kabuto, M., Niskar, A. S., and Rubin, C. (2005). Associations between serum levels of selected organochlorine compounds and endometripsis in infertile Japanese women. Environ. Res. 99 118-125.
119. Ullah, S., and Griffiths, P. (2003). Does the use of pacifiers shorten breastfeeding duration in infants? Br. J. Community Nurs. 8, 458 (Abstract).
120. Unfer, V., Casini, M. L., Costabile, L., Mignosa, M., Gerli, S., and Di Renzo, G. C. (2004). Endometrial effects of long-term treatment with phytoestrogens: A randomized, double-blind, placebo-controlled study. Fertil. Steril. 82, 145-148.
121. varr der Horst, M., Falck Winther, J., and Olsen, J. H. (2006). Cancer incidence in the age range 0-34 years: Historical and actual status in Denmark. Int. J. Cancer 118, 2816-2826.
122. van der Tweel, I. (2005). Repeated looks at accumulating data: To correct or not to correct? Eur J. Epidemiol. 20, 205-211.
123. Vorderstrasse, B. A., Fenton, S. E., Bohn, A. A., Cundiff, J. A., and Lawrence, B. P. (2004). A novel effect of dioxin: Exposure during pregnancy severely impairs mammary gland differentiation. Toxicol. Sci. 78, 248-257.
124. Waylen, A., and Wolke, D. (2004). Sex 'n' drugs 'n' rock 'n' roll: The meaning and social consequences of pubertal timing. Eur. J. Endocrin. 151, U151-U159.
125. Wiedemann, P. M., and Schütz, H. (2005). The precautionary principle and risk perception: Experimental studies in the EMF area. Environ. Health Perspect. 113, 402-405.
126. Witorsch, R. J. (2002). Low-dose in utero effects of xenoestrogens in mice and their relevance to humans: An analytical review of the literature. Food Chem. Toxicol. 40, 905-912.
127. World Health Organisation (WHO) (2001). Current Practices and Controversies in Assisted Reproduction. Medical, Ethical and Social Aspects of Assisted Reproduction. World Health Organisation, Geneva, Switzerland.
128. World Health Organisation (WHO) (2006). Fact sheet No297. World Health Organisation, Geneva, Switzerland.
129. World Health Organisation (WHO) (2004). World Health Report 2004 - Changing History. World Health Organisation, Geneva, Switzerland. 96 p.
130. Zhu, Z., Boobis, A. R., and Edwards, R. J. (2006). Use of protein profiles to characterise concentration-effect curves of mixtures of estrogenic compounds in human breast cell lines. Toxicol. Lett. 164, S165-S166.