Consumption of xenoestrogen-contaminated fish during lactation alters adult male reproductive function

Toxicological Sciences

Volumn 81, Issue 1, 2004, Pages 179-189

  Aravindakshan, Jayaprakash ^a   Gregory, Mary ^a   Marcogliese, David J ^b   Fournier, Michel ^a   Cyr, Daniel G ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

^b ENVIRONMENT CANADA   (Canada)

Author keywords

Gap junctions; Sperm motility; Spermatogenesis; Xenoestrogen

Indexed keywords

CONNEXIN 43; ESTROGEN; GAP JUNCTION PROTEIN; MESSENGER RNA; TESTOSTERONE; VITELLOGENIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; EPIDIDYMIS; FISH; FOOD CONTAMINATION; FOOD INTAKE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LACTATION; MALE; MALE GENITAL SYSTEM FUNCTION; NONHUMAN; ORGAN WEIGHT; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE EPITHELIUM; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TESTIS FUNCTION;

ANIMALS; ANIMALS, SUCKLING; BODY WEIGHT; CONNEXIN 43; ENVIRONMENTAL POLLUTANTS; EPIDIDYMIS; ESTROGENS, NON-STEROIDAL; FEMALE; FISHES; FOOD CHAIN; FOOD CONTAMINATION; IMMUNOHISTOCHEMISTRY; LACTATION; MALE; MEAT; ORGAN SIZE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; RNA, MESSENGER; SPERM MOTILITY; SPERMATOGENESIS; TESTIS; TESTOSTERONE; VITELLOGENINS; XENOBIOTICS;

EID: 4444358785     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh174     Document Type: Article

References (45)

1. Aravindakshan, J., Paquet, V., Gregory, M., Dufresne, J., Fournier, M., Marcogliese, D. J. and Cyr, D. G. (2004). Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius). Toxicol. Sci. 78, 156-165.
2. Arukwe, A. (2001). Cellular and molecular responses to endocrine-modulators and the impact on fish reproduction. Mar. Pollut. Bull. 42, 643-655.
3. Batias, C., Siffroi, J. P., Fénichel, P., Pointis, G., and Segretain, D. (2000). Connexin43 gene expression and regulation in the rodent seminiferous epithelium. J. Histochem. Cytochem. 48, 793-805.
4. Boyer, I. J, Kokoski, C. J., Bolger, P. M. (1991). Role of FDA in establishing tolerable levels for dioxin and PCBs in aquatic organisms. J. Toxicol. Environ. Health 33, 93-101.
5. Bowerman, W. W, Giesy, J. P, Best, D. A., and Kramer, V. J. (1995). A review of factors affecting productivity of bald eagles in the Great Lakes region - Implications for recovery. Environ. Health Perspect. 103, 51-59.
6. Chan, H. M., Trifonopoulos, M., Ing, A., Receveur, O., Johnson, E. (1999). Consumption of freshwater fish in Kahnawake: risks and benefits. Environ. Res. 80, S213-S222.
7. Chapin, R. E., Morgan, K. T,. and Bus, J. S. (1983). The morphogenesis of testicular degeneration by orally administered 2,5-hexanedione. Exp. Mol. Pathol. 38, 149-169.
8. Chapin, R. E., Dutton, S. L., Ross, M. D., Sumrell, B. M., and Lamb, J. C. (1984). The effects of ethylene glycol monomethyl ether on testicular histology in F344 rats. J. Androl. 5, 369-380.
9. Chomczynski, P., and Sacchi, N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
10. Colborn, T. (1991). Epidemiology of Great Lakes bald eagles. J. Toxicol. Environ. Health 33, 395-453.
11. Creasy, D. M., Glynn, J. C., Gray, T. J. B., and Butler, W. H. (1985). A quantitative study of stage-specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat. Exp. Mol. Pathol. 43, 321-336.
12. Cyr, D. G. (2001). Cell-cell interactions in the epididymis. In Andrology in the Twenty First Century (B. Robaire, C. Morales, and H. Chemes, eds.), pp. 215-226. Medimond Medical Publications, New York.
13. Cyr, D. G., Finnson, K. W., Dufresne, J., and Gregory, M. (2002). Cellular interactions and the blood-epididymal barrier. In The Epididymis: From Molecules to Clinical Practice (B. Robaire and B. Hinton, eds), pp. 103-118. Plenum Press. New York.
14. Defamie, N., Berthaut, I., Mograbi, B., Chevallier, D., Dadoune, J. P., Fenichel, P., Segretain, D., and Pointis, G. (2003). Impaired gap junction connexin43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells. Lab. Invest. 83, 449-456.
15. de Solla, S. R., Bishop, C. A., Van der Kraak, G., and Brooks, R. J. (1998). Impact of organochlorine contamination on levels of sex hormones and external morphology of common snapping turtles (Chelydra serpentina serpentina) in Ontario, Canada. Environ. Health Perspect. 106, 253-260.
16. Fein, G. G., Jacobson, J. L, Jacobson, S. W, Schwartz, P. M., and Dowler, J. (1984). Prenatal exposure to polychlorinated biphenyls: Effects on birth size and gestational age. J. Pediatr. 105, 315-320.
17. Gagnon, C., and Saulnier, I. (2003). Distribution And fate of metals in the dispersion plume of a major municipal effluent. Environ. Pollut. 124, 47-55.
18. Giesy, J. P., Ludwig, J. P., and Tillitt, D. E (1994). Deformities in birds of the Great Lakes region: Assigning causality. Environ. Sci. Technol. 28, 128-135.
19. Goyal, H. O., Robateau, A., Braden, T. D., Williams, C. S., Srivastava, K. K., and Ali, K. (2003). Neonatal estrogen exposure of male rats alters reproductive functions at adulthood. Biol. Reprod. 68, 2081-2091.
20. Guillette, L. J., Gross, T. S., Masson, G. R., Matter, J. M., Percival, H. F., and Woodward, A. R. (1994). Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environ. Health Perspect. 102, 680-688.
21. Guillette, L. J., Pickford, D. B., Crain, D. A., Rooney, A. A., and Percival, H. F. (1996). Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment. Gen. Comp. Endocrinol. 101, 32-42.
22. Hess, R. A. (1998). Effects of environmental toxicants on the efferent ducts, epididymis and fertility. J. Reprod. Fertil. 53, 247-259.
23. Hirano, Y., Shibahara, H., Obara, H., Suzuki, T., Takamizawa, S., Yamaguchi, C., Tsunoda, H. and Sato, I. (2001). Relationships between sperm motility characteristics assessed by the computer-aided sperm analysis (CASA) and fertilization rates in vitro. J. Assist. Reprod. Genet. 18, 213-218.
24. Jacobson, J. L, Fein, G. G, Jacobson, S. W, Schwartz, P. M., and Dowler, J. K. (1984). The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) across the human placenta and into maternal milk. Am. J. Public Health 74, 378-379.
25. Jacobson, J. L., and Jacobson, S. W (1988). New methodologies for assessing the effects of prenatal toxic exposure on cognitive functioning in humans. In Toxic Contaminants and Ecosystem Health: A Great Lakes Focus (M. S. Evans, ed.), pp. 373-387. Wiley, New York.
26. Jobling, S., and Sumpter, J. P. (1993). Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 27, 361-372.
27. Jobling, S., and Tyler, C. R. (2003). Endocrine disruption, parasites and pollutants in wild freshwater fish. Parasitology 126, S103-S108.
28. Klinefelter, G. R., Suarez, J. D. (1997). Toxicant-induced acceleration of epididymal sperm transit: Androgen-dependent proteins may be involved. Reprod. Toxicol. 11, 511-519.
29. Kosatsky, T., Przybysz, R., Shatenstein, B., Weber, J. P., and Armstrong, B. (1999a). Fish consumption and contaminant exposure among Montreal-area sportfishers: Pilot study. Environ. Res. 80, S150-S158.
30. Kosatsky, T., Przybysz, R., Shatenstein, B., Weber, J. P., and Armstrong, B. (1999b). Contaminant exposure in Montrealers of Asian origin fishing the St. Lawrence River: Exploratory assessment. Environ. Res. 80, S159-S165.
31. Leblond, C., and Clermont, Y. (1952). Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann. N. Y. Acad. Sci. 55, 548-573.
32. Mograbi, B., Corcelle, E., Defamie, N., Samson, M., Nebout, M., Segretain, D., Fenichel, P. and Pointis, G. (2003). Aberrant connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway. Carcinogenesis 24, 1415-1423.
33. Oko, R., and Clermont, Y. (1989). Light microscopic immunocytochemical study of fibrous sheath and outer dense fiber formation in the rat spermatid. Anat. Rec. 225, 46-55.
34. Parvinen, M., and Vanha-Perttula, T. (1972). Identification and enzyme quantitation of the stages of the seminiferous epithelial wave in the rat. Anat. Rec. 174, 435-449.
35. Patanelli, D. J., and Nelson, W. O. (1964). A quantitative study of inhibition and recovery of spermatogenesis. Recent Prog. Horm. Res. 20, 491-543.
36. Pelletier, R. M. (2001). The tight junctions in the testis, epididymis, and vas deferens. In Tight Junctions (M. Cereijido and J. Anderson, eds.), pp. 599-628. CRC Press, Boca Raton, FL.
37. Risley, M. S., Tan, I. P., Roy, C., and Sáez, J. C. (1992). Cell-, age- and stage-dependent distribution of connexin43 gap junctions in testes. J. Cell Sci. 103, 81-96.
38. Rodriguez, C. M., Kirby, J. L., Hinton, B. T. (2002). The development of the epididymis. In The Epididymis: From Molecules to Clinical Practice (B. Robaire and B. Hinton, eds.), pp. 251-268. Plenum Press, New York.
39. Roscoe, W. A., Barr, K. J., Mhawi, A. A., Pomerante, D. K., and Kidder, G. M. (2001). Failure of spermatogenesis in mice lacking Cx43. Biol. Reprod. 65, 829-838.
40. Rothcell, J. M., and Ostrander, G. K. (2003). Molecular markers of endocrine disruption in aquatic organisms. J. Toxicol. Environ. Health B Crit. Rev. 6, 453-496.
41. Sabik, H., Gagne, F., Blaise, C., Marcogliese, D. J., and Jeannot, R. (2003). Occurrence of alkylphenol polyethoxylates in the St. Lawrence River and their bioconcentration by mussels (Elliptio complanata). Chemosphere 51, 349-356.
42. St-Pierre, N., Dufresne, J., Rooney, A. A., and Cyr, D. G. (2003). Neonatal hypothyroidism alters the localization of gap junctional protein connexin 43 in the testis and messenger RNA levels in the epididymis of the rat. Biol. Reprod. 68, 1232-1240.
43. Tan, I. P., Roy, C., Sáez, J. C., Sáez, C. G., Paul, D. L., and Risley, M. S. (1996). Regulated assembly of connexin33 and connexin43 into rat Sertoli cell gap junctions. Biol. Reprod. 54, 1300-1310.
44. Tyler, C. R., van der Eerden, B., Jobling, S., Panter, G., and Sumpter, J. P. (1996). Measurement of vitellogenin, a biomarker for exposure to oestrogenic chemicals, in a wide variety of cyprinind fish. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 166, 418-426.
45. Yeung C. H., Cooper, T. G. (2002). Acquisition and development of sperm motility upon maturation in the epididymis. In The Epididymis: From Molecules to Clinical Practice (B. Robaire and B. Hinton, eds.), pp. 417-434. Plenum Press, New York.