High prevalence of molecular markers for resistance to chloroquine and pyrimethamine in Plasmodium falciparum from Zimbabwe

Parasitology Research

Volumn 101, Issue 4, 2007, Pages 1147-1151

  Mlambo, Godfree ^a,b   Sullivan, David ^a   Mutambu, Susan L ^b   Soko, White ^b   Mbedzi, Joel ^b   Chivenga, James ^b   Gemperli, Armin ^a   Kumar, Nirbhay ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b NATIONAL INSTITUTE OF HEALTH RESEARCH   (Zimbabwe)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; FANSIDAR;

ADOLESCENT; ADULT; ARTICLE; CHLOROQUINE RESISTANCE TRANSPORTER GENE; CODON; CONTROLLED STUDY; DIHYDROFOLATE REDUCATASE GENE; DNA EXTRACTION; GENE; GENE LOCUS; GENE MUTATION; HUMAN; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALARIA; MALARIA CONTROL; NONHUMAN; PARASITE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; TREATMENT OUTCOME; ZIMBABWE;

ADOLESCENT; ADULT; ANIMALS; ANTIMALARIALS; CHLOROQUINE; DNA, PROTOZOAN; DRUG COMBINATIONS; DRUG RESISTANCE; HUMANS; MALARIA, FALCIPARUM; MUTATION; PLASMODIUM FALCIPARUM; PREVALENCE; PROTOZOAN PROTEINS; PYRIMETHAMINE; SULFADOXINE; ZIMBABWE;

PLASMODIUM FALCIPARUM;

EID: 34547795310     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-007-0597-5     Document Type: Article

References (22)

1. Bloland PB, Lackritz EM, Kazembe PN, Were JB, Steketee R and Campbell CC (1993) Beyond chloroquine: implications of drug resistance for evaluating malaria therapy and treatment policy in Africa. J Infect Dis 167:932-937
2. Brooks DR, Wang P, Read M, Watkins WM, Sims PF and Hyde JE (1994) Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem 224:397-405
3. Creasey A, Fenton B, Walker A, Thaithong S, Oliveira S, Mutambu S and Walliker D (1990) Genetic diversity of Plasmodium falciparum shows geographical variation. Am J Trop Med Hyg 42:403-413
4. Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Dioute Y, Dicko A, Su X, Nomura T, Fidock DA, Wellems TE and Plowe CV (2001) A molecular marker for chloroquine resistant falciparum malaria. N Engl J Med 344:257-263
5. Djimde AA, Dolo A, Quattara A, Diakite S, Plowe CV and Doumbo OK (2004) Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones. J Infect Dis 190:853-855
6. Doumbo OK, Kayentao K, Djimde A, Cortese JF, Diourte Y, Konare A, Kublin JG and Plowe CV (2000) Rapid selection of Plasmodium falciparum dihydrofolate reductase mutants by pyrimethamine prophylaxis. J Infect Dis 182:993-996
7. Duraisingh MT, Curtis J and Warhurst DC (1998) Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol 89:1-8
8. Duraisingh MT, Jones P, Sambou I, Seidlein L, Pinder M and Warhurst DC (2000) The tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol 108:13-23
9. Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LMB, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD and Wellems TE (2000) Mutations in the Plasmodium falciparum digestive vacuole transmembrane protein Pfcrt and evidence for their role in chloroquine resistance. Mol Cell 6:861-871
10. Foote SJ, Kyle DE, Martin RK, Oduola AMJ, Forsyth K, Kemp DJ and Cowman AF (1990) Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature 345:255-258
11. Kublin JG, Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, Martino LM, Mukadam RAG, Rogerson SJ, Lescano AG, Molyneux ME, Winstanley PA, Chimpeni P, Taylor TE and Plowe CV (2002) Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmdoium falciparum malaria. J Infect Dis 185:380-388
12. Kublin JG, Cortese JF, Njunju EM, Mukadam RA, Wirima JJ, Kazembe PN, Djimde AA, Kouriba B, Taylor TE and Plowe CV (2003) Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. J Infect Dis 187:1870-1875
13. Mendis K, Sina B, Marchesini P and Carter R (2001) The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64:97-106
14. Mharakurwa S, Mutambu SL, Mudyiradima R, Chimbadzwa T, Chandiwana SK and Day KP (2004) Association of house spraying with suppressed levels of drug resistance in Zimbabwe. Malaria J 3:35
15. Mlambo G, Mutambu SL, Mduluza T, Soko W, Mbedzi J, Chivenga J, Lanar DE, Singh S, Carucci D, Gemperli A and Kumar N (2006) Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude. Acta Trop 100:70-78
16. Peterson DS, Milhous WK and Wellems TE (1990) Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci U S A 87:3018-3022
17. Plowe CV, Djimde A, Bouare M, Doumbo O and Wellems TE (1995) Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 52:565-568
18. Plowe CV, Cortese JF, Djimde A, Nwanyanwu OC, Watkins WM, Winstanley PA, Estrada-Franco JG, Mollinedo RE, Avila JC, Cespedes JL, Carter R and Doumbo OK (1997) Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiological patterns of pyrimethamine- sulfadoxine use and resistance. J Infect Dis 176:1590-1596
19. Price RN, Cassar C, Brockman A, Duraisingh M, Vugt M, White NJ, Nosten F and Krishna S (1999) The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother 43:2943-2949
20. Sirawaraporn W, Sathitkul T, Sirawaraporn R, Yuthavong Y and Santi DV (1997) Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc Natl Acad Sci U S A 94:1124-1129
21. Taylor P and Mutambu SL (1986) A review of the malaria situation in Zimbabwe with special reference to the period 1972-1981. Trans R Soc Trop Med Hyg 80:12-19
22. Wang J, Read M, Sims PFG and Hyde JE (1997) Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol Microbiol 23:979-986