Digital autoradiography using room temperature CCD and CMOS imaging technology

Physics in Medicine and Biology

Volumn 52, Issue 16, 2007, Pages 4993-5011

  Cabello, Jorge ^a   Bailey, Alexis ^a   Kitchen, Ian ^a   Prydderch, Mark ^b   Clark, Andy ^b   Turchetta, Renato ^b   Wells, Kevin ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b RUTHERFORD APPLETON LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGE COUPLED DEVICES; CMOS INTEGRATED CIRCUITS; IMAGE SENSORS; PIXELS; RADIOGRAPHY; TISSUE;

AUTORADIOGRAPHY; PIXEL SENSORS; TISSUE SAMPLES;

MEDICAL IMAGING;

CARBON 14; SILICON; SULFUR 35; TRITIUM;

ARTICLE; AUTORADIOGRAPHY; CALIBRATION; COMPARATIVE STUDY; DIGITAL IMAGING; FILM; IRRADIATION; ISOTOPE LABELING; LINEAR SYSTEM; PRIORITY JOURNAL; ROOM TEMPERATURE; SENSOR; SPECTRAL SENSITIVITY; TECHNOLOGY; TISSUE SECTION;

AUTORADIOGRAPHY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; RADIATION DOSAGE; RADIOGRAPHIC IMAGE ENHANCEMENT; RADIOMETRY; REPRODUCIBILITY OF RESULTS; SEMICONDUCTORS; SENSITIVITY AND SPECIFICITY; TEMPERATURE; TRANSDUCERS;

EID: 34547780783     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/52/16/019     Document Type: Article

References (42)

1. Abate L, Bertolucci E, Conti M, Mettivier G, Montesi M C and Russo P 2001 GaAs pixel arrays for β imaging in medicine and biology Nucl. Instrum. Methods A 460 97-106
2. Arvanitis C D et al 2006 A novel active pixel sensor with on-pixel analog-to-digital converter for mammography IEEE Nucl. Sci. Symp. Medical Imaging Conf. (San Diego, USA, 29 Oct.-4 Nov.) vol 6 pp 3576-80
3. 2A adenosine receptor knockout mice J. Neurochem. 88 827-34
4. Barthe N, Chatti K, Coulon P, Maitrejean S and Basse-Cathalinat B 2004 Recent technologic developments on high-resolution beta imaging for quantitative autoradiography and double labeling applications Nucl. Instrum. Methods A 527 41-5
5. ppm Tc J. Nucl. Med. 40 868-75
6. Bertolucci E et al 1996 Autoradiography with silicon strip detectors Nucl. Instrum. Methods A 381 527-30
7. Bertolucci E, Conti M, Mettivier G and Montesi M C 2002 BETAview: a digital β-imaging system for dynamic studies of biological phenomena Nucl. Instrum. Methods A 478 109-13
8. Cabello J et al 2006 Digital autoradiography using CCD and CMOS imaging technology IEEE Nucl. Sci. Symp. Medical Imaging Conf. (San Diego, USA, 29 Oct.-4 Nov.) vol 4 pp 2607-12
9. Carlson B S 2002 Comparison of modern CCD and CMOS image sensor technologies and systems for low resolution imaging Proc. IEEE Sensors 1 171-6
10. Charpak G, Dominik W and Zagandis N 1989 Optical imaging of the spatial distribution of β-particles emerging from surfaces Proc. Natl Acad. Sci. USA 86 1741-5
11. Cross W G, Ing H and Freedman N 1983 A short atlas of beta-ray spectra Phys. Med. Biol. 28 1251-60
12. Deptuch G 2005 Tritium autoradiography with thinned and back-side illuminated monolithic active pixel sensor device Nucl. Instrum. Methods A 543 537-48
13. Janesick J 2002 Lux transfer: CMOS versus CCD Proc. SPIE 4669 232-49
14. Johnston R F, Pickett S C and Barker D L 1990 Autoradiography using storage phosphor technology Electrophoresis 11 355-60
15. Karellas A, Liu H, Reindhart C, Harris L J and Brill A B 1993 Imaging of radionuclide emissions with a low-noise charge-coupled device IEEE Trans. Nucl. Sci. 40 979-82
16. Kokkinou E, Wells K, Petrou M and Bailey A 2003 Digital autoradiography imaging using direct irradiation of a CCD between 278-309 K IEEE Trans. Nucl. Sci. 50 1702-7
17. 14 autoradiography IEEE Trans. Nucl. Sci. 45 1288-92
18. Lees J E, Murray A, Perkins A C and Fraser G W 2002 Autoradiography of high-energy radionuclides using a microchannel plate detector IEEE Trans. Nucl. Sci. 49 153-5
19. Lees J E, Pearson J F, Fraser G W, Hales J M and Richards P G 1999 An MCP-based system for beta autoradiography IEEE Trans. Nucl. Sci. 46 636-8
20. Lena I, Kieffer B and Kitchen I 2004 Quantitative autoradiography of dopamine receptors in the brains of ν-opioid receptor knockout mice Neurosci. Lett. 356 220-4
21. Ljunggren K and Strand S E 1990 Beta camera for static and dynamic imaging of charged-particle emitting radionuclides in biologic samples J. Nucl. Med. 31 2058-63
22. Magnan P 2003 Detection of visible photons in CCD and CMOS: a comparative view Nucl. Instrum. Methods 504 199-212
23. Marczewski J et al 2005 Monolithic silicon pixel detectors in SOI technology Nucl. Instrum. Methods A 549 112-6
24. Mettivier G, Montesi M C and Russo P 2003 First images of a digital autoradiography system based on a Medipix2 hybrid silicon pixel detector Phys. Med. Biol. 48 173-81
25. Mettivier G, Montesi M C and Russo P 2004 Tritium digital autoradiography with a Medipix2 hybrid silicon pixel detector Nucl. Instrum. Methods 516 554-63
26. Mettivier G, Montesi M C and Russo P 2005 Digital autoradiography with a Medipix2 hybrid silicon pixel detector IEEE Trans. Nucl. Sci. 52 46-50
27. Moraes D et al 2004 A novel low noise hydrogenated amorphous silicon pixel detector J. Non-Cryst. Solids 338-340 729-31
28. Neeser W et al 2000 The DEPFET pixel BIOSCOPE IEEE Trans. Nucl. Sci. 47 1246-50
29. Niemiec H et al 2005 Monolithic active pixel sensor realized in SOI technology concept and verification Microelectron. Reliab. 45 1202-7
30. NIST 2000 Physical Reference Data, E-STAR, http://physics.nist.gov/ PhysRefData/Star/Text/
31. Ott R J, MacDonald J and Wells K 2000 The performance of a CCD digital autoradiography imaging system Phys. Med. Biol. 45 2011-27
32. Overdick M et al 1997 A 'Bioscope' system using double-sided silicon strip detectors and self-triggering read-out chips Nucl. Instrum. Methods A 392 173-7
33. Petegnief Y, Petiet A, Peker M C, Bonnin F, Meulemans A and Guludec D 1998 Quantitative autoradiography using a radioimager based on a multiwire proportional chamber Phys. Med. Biol. 43 3629-39
34. 14C Phys. Rev. 97 432-3
35. Prydderch M L et al 2003 A 512 × 512 CMOS monolithic active pixel sensor with integrated ADCs for space science Nucl. Instrum. Methods 512 358-67
36. Puertolas D, Piedigrossi D, Leutz H, Gys T and D'Ambrosio C 1996 An ISPA camera for beta radiography IEEE Trans. Nucl. Sci. 43 2477-87
37. Reichert W L, Stein J E, French B, Goodwin P and Varanasi U 1992 Storage phosphor imaging technique for detection and quantitation of DNA adducts measured by the 32P-postlabeling assay Electrophoresis 13 1475-9
38. Tribollet E, Dreiffus J J, Charpak G, Dominik W and Zaganidis N 1991 Localization and quantitation of tritiated compounds in tissue sections with a gaseous detector of β particles: comparison with film autoradiography Proc. Natl Acad. Sci. 88 1466-8
39. Turchetta R et al 2001 A monolithic active pixel sensor for charged particle tracking and imaging using standard VLSI CMOS technology Nucl. Instrum. Methods 458 677-89
40. Ulrici J, Fischer P, Klein P, Lutz G, Neeser W, Richter R, Strüder L, Trimpl M and Wermes N 2005 Imaging performance of a DEPFET pixel bioscope system in tritium autoradiography Nucl. Instrum. Methods A 547 424-36
41. Wells K and Kokkinou E 2006 Imaging system for use in autoradiography UK Patent GB2397959
42. Wermes N 2004 Trends in pixel detectors: tracking and imaging IEEE Trans. Nucl. Sci. 51 1006-15