메뉴 건너뛰기




Volumn 94, Issue SPEC. ISS., 2007, Pages

Gemcitabine and digestive carcinomas;Gemcitabine en cancérologie digestive

Author keywords

Cholangiocarcinoma; Gallbladder carcinoma; Gemcitabine; Hepatocarcinoma; Pancreatic adenocarcinoma

Indexed keywords

CAPECITABINE; CISPLATIN; DOCETAXEL; ERLOTINIB; FLUOROURACIL; GEMCITABINE; IRINOTECAN; MARIMASTAT; MITOMYCIN; OXALIPLATIN; PEMETREXED; TIPIFARNIB;

EID: 34547772719     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1684/bdc.2007.0249     Document Type: Review
Times cited : (4)

References (112)
  • 1
    • 0028292341 scopus 로고
    • Phase II trial of gemcitabine (2,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas
    • Casper ES, Green MR, Kelsen DP, Heelan RT, Brown TD, Flombaum CD, et al. Phase II trial of gemcitabine (2,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 1994 ; 12 : 29-34.
    • (1994) Invest New Drugs , vol.12 , pp. 29-34
    • Casper, E.S.1    Green, M.R.2    Kelsen, D.P.3    Heelan, R.T.4    Brown, T.D.5    Flombaum, C.D.6
  • 4
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer : A randomized trial
    • Burris 3rd HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer : a randomized trial. J Clin Oncol 1997 ; 15 : 2403-13.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris 3rd, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 5
    • 0032958512 scopus 로고    scopus 로고
    • Mechanisms of synergism berween cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines
    • van Moorsel CJ, Pinedo HM, Veerman G, Bergman AM, Kuiper CM, Vermorken JB, et al. Mechanisms of synergism berween cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines. Br J Cancer 1999 ; 80 : 981-90.
    • (1999) Br J Cancer , vol.80 , pp. 981-990
    • van Moorsel, C.J.1    Pinedo, H.M.2    Veerman, G.3    Bergman, A.M.4    Kuiper, C.M.5    Vermorken, J.B.6
  • 8
    • 0028240063 scopus 로고
    • Metabolism of 2′, 2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells
    • Shewach DS, Hahn TM, Chang E, Hertel LW, Lawrence TS. Metabolism of 2′, 2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res 1994 ; 54 : 3218-23.
    • (1994) Cancer Res , vol.54 , pp. 3218-3223
    • Shewach, D.S.1    Hahn, T.M.2    Chang, E.3    Hertel, L.W.4    Lawrence, T.S.5
  • 9
    • 13744249204 scopus 로고    scopus 로고
    • The frequency of cancer in France in year 2000, and trends since 1950]
    • Hill C, Doyon F. [The frequency of cancer in France in year 2000, and trends since 1950]. Bull Cancer 2005 ; 92 : 7-11.
    • (2005) Bull Cancer , vol.92 , pp. 7-11
    • Hill, C.1    Doyon, F.2
  • 10
    • 0023626809 scopus 로고
    • Cancer of the pancreas. 50 years of surgery
    • Gudjonsson B. Cancer of the pancreas. 50 years of surgery. Cancer 1987 ; 60 : 2284-303.
    • (1987) Cancer , vol.60 , pp. 2284-2303
    • Gudjonsson, B.1
  • 12
    • 0017293724 scopus 로고
    • Carcinoma of the pancreas : Review of MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy
    • Tepper J, Nardi G, Sutt H. Carcinoma of the pancreas : review of MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy. Cancer 1976 ; 37 : 1519-24.
    • (1976) Cancer , vol.37 , pp. 1519-1524
    • Tepper, J.1    Nardi, G.2    Sutt, H.3
  • 13
    • 0031426723 scopus 로고    scopus 로고
    • Pancreaticoduodenectomy for pancreatic adenocarcinoma : Postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience
    • discussion 633-6
    • Yeo CJ, Abrams RA, Grochow LB, Sohn TA, Ord SE, Hruban RH, et al. Pancreaticoduodenectomy for pancreatic adenocarcinoma : postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg 1997 ; 225 : 621-33 ; (discussion 633-6).
    • (1997) Ann Surg , vol.225 , pp. 621-633
    • Yeo, C.J.1    Abrams, R.A.2    Grochow, L.B.3    Sohn, T.A.4    Ord, S.E.5    Hruban, R.H.6
  • 14
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 2004 ; 350 : 1200-10.
    • (2004) N Engl J Med , vol.350 , pp. 1200-1210
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3    Bassi, C.4    Dunn, J.A.5    Hickey, H.6
  • 15
    • 33846405332 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial
    • Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. Jama 2007 ; 297 : 267-77.
    • (2007) Jama , vol.297 , pp. 267-277
    • Oettle, H.1    Post, S.2    Neuhaus, P.3    Gellert, K.4    Langrehr, J.5    Ridwelski, K.6
  • 16
    • 33746149215 scopus 로고    scopus 로고
    • RTOG 9704 a phase III study of adjuvant pre and post chemoradiation 5-FU vs. gemcitabine for resected pancreatic adenocarcinoma
    • Regine WF, Winter KW, Abrams R, Safran H, Hoffman JP, Konski A, et al. RTOG 9704 a phase III study of adjuvant pre and post chemoradiation 5-FU vs. gemcitabine for resected pancreatic adenocarcinoma. J Clin Oncol 2006 ; 24 : 4007.
    • (2006) J Clin Oncol , vol.24 , pp. 4007
    • Regine, W.F.1    Winter, K.W.2    Abrams, R.3    Safran, H.4    Hoffman, J.P.5    Konski, A.6
  • 17
    • 33846908072 scopus 로고    scopus 로고
    • Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in Gercor phase II and III studies
    • Huguet F, Andre T, Hammel P, Artru P, Balosso J, Selle F, et al. Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in Gercor phase II and III studies. J Clin Oncol 2007 ; 25 : 326-31.
    • (2007) J Clin Oncol , vol.25 , pp. 326-331
    • Huguet, F.1    Andre, T.2    Hammel, P.3    Artru, P.4    Balosso, J.5    Selle, F.6
  • 18
    • 33646910394 scopus 로고    scopus 로고
    • Chemoradiotherapy after chemotherapy improves survival for locally-advanced pancreatic cancer patients : Retrospective analysis of 181 patients enrolled in prospective phases II and III Gercor studies
    • Huguet F, Andre T, Hammel P, Artru P, Balosso J, Ruszniewski P, et al. Chemoradiotherapy after chemotherapy improves survival for locally-advanced pancreatic cancer patients : retrospective analysis of 181 patients enrolled in prospective phases II and III Gercor studies. J Clin Oncol 2005 ; 23 : 4095.
    • (2005) J Clin Oncol , vol.23 , pp. 4095
    • Huguet, F.1    Andre, T.2    Hammel, P.3    Artru, P.4    Balosso, J.5    Ruszniewski, P.6
  • 19
    • 0036089040 scopus 로고    scopus 로고
    • Gemcitabine and ionizing radiations : Radiosensitization or radio-chemotherapy combination]
    • Azria D, Jacot W, Prost P, Culine S, Ychou M, Lemanski C, et al. [Gemcitabine and ionizing radiations : radiosensitization or radio-chemotherapy combination]. Bull Cancer 2002 ; 89 : 369-79.
    • (2002) Bull Cancer , vol.89 , pp. 369-379
    • Azria, D.1    Jacot, W.2    Prost, P.3    Culine, S.4    Ychou, M.5    Lemanski, C.6
  • 20
    • 0036534672 scopus 로고    scopus 로고
    • Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer?
    • Crane CH, Abbruzzese JL, Evans DB, Wolff RA, Ballo MT, Delclos M, et al. Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer? Int J Radiat Oncol Biol Phys 2002 ; 52 : 1293-302.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 1293-1302
    • Crane, C.H.1    Abbruzzese, J.L.2    Evans, D.B.3    Wolff, R.A.4    Ballo, M.T.5    Delclos, M.6
  • 21
    • 0042566185 scopus 로고    scopus 로고
    • Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer : Gemcitabine versus 5-fluorouracil, a randomized controlled study
    • Li CP, Chao Y, Chi KH, Chan WK, Teng HC, Lee RC, et al. Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer : gemcitabine versus 5-fluorouracil, a randomized controlled study. Int J Radiat Oncol Biol Phys 2003 ; 57 : 98-104.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 98-104
    • Li, C.P.1    Chao, Y.2    Chi, K.H.3    Chan, W.K.4    Teng, H.C.5    Lee, R.C.6
  • 22
    • 0000480156 scopus 로고    scopus 로고
    • A comparison between gemcitabine and the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced pancreatic cancer
    • Moore M, Hamm J, Eisenberg P, Dagenais M, Hagan K, Fields A, et al. A comparison between gemcitabine and the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced pancreatic cancer. Proc Am Soc Clin Oncol 2000 ; 19 : 930.
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 930
    • Moore, M.1    Hamm, J.2    Eisenberg, P.3    Dagenais, M.4    Hagan, K.5    Fields, A.6
  • 23
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine : Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero M, Plunkett W, Ruiz Van Haperen V, Hainsworth J, Hochster H, Lenzi R, et al. Randomized phase II comparison of dose-intense gemcitabine : thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 2003 ; 21 : 3402-8.
    • (2003) J Clin Oncol , vol.21 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz Van Haperen, V.3    Hainsworth, J.4    Hochster, H.5    Lenzi, R.6
  • 24
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma : Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma : Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 2002 ; 20 : 3270-5.
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson, A.B.6
  • 25
    • 34547814649 scopus 로고    scopus 로고
    • Riess H, Helm A, Niedergethmann M, Schmidt-Wolf I, Moik M, Hammer C, et al. A randomised, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs. gemcitabine alone in patients with advanced pancreatic cancer. J Clin Oncol 2005 ; 23 : LBA4009.
    • Riess H, Helm A, Niedergethmann M, Schmidt-Wolf I, Moik M, Hammer C, et al. A randomised, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs. gemcitabine alone in patients with advanced pancreatic cancer. J Clin Oncol 2005 ; 23 : LBA4009.
  • 26
    • 34250180939 scopus 로고    scopus 로고
    • Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: A randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group
    • Herrmann R, Bodoky G, Ruhstaller T, Glimelius B, Bajetta E, Schuller J, et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 2007 ; 25 : 2212-7.
    • (2007) J Clin Oncol , vol.25 , pp. 2212-2217
    • Herrmann, R.1    Bodoky, G.2    Ruhstaller, T.3    Glimelius, B.4    Bajetta, E.5    Schuller, J.6
  • 27
    • 29344476191 scopus 로고    scopus 로고
    • Phase III randomised comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken D, Davies C, Dunn J, Valle J, et al. Phase III randomised comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. Eur J Cancer Suppl 2005 ; 3 : 4.
    • (2005) Eur J Cancer Suppl , vol.3 , pp. 4
    • Cunningham, D.1    Chau, I.2    Stocken, D.3    Davies, C.4    Dunn, J.5    Valle, J.6
  • 28
    • 0033635935 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer
    • Heinemann V, Wilke H, Mergenthaler HG, Clemens M, Konig H, Illiger HJ, et al. Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer. Ann Oncol 2000 ; 11 : 1399-403.
    • (2000) Ann Oncol , vol.11 , pp. 1399-1403
    • Heinemann, V.1    Wilke, H.2    Mergenthaler, H.G.3    Clemens, M.4    Konig, H.5    Illiger, H.J.6
  • 29
    • 0035425508 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma
    • Philip PA, Zalupski MM, Vaitkevicius VK, Arlauskas P, Chaplen R, Heilbrun LK, et al. Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma. Cancer 2001 ; 92 : 569-77.
    • (2001) Cancer , vol.92 , pp. 569-577
    • Philip, P.A.1    Zalupski, M.M.2    Vaitkevicius, V.K.3    Arlauskas, P.4    Chaplen, R.5    Heilbrun, L.K.6
  • 30
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma : A prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • Colucci G, Giuliani F, Gebbia V, Biglietto M, Rabitti P, Uomo G, et al. Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma : a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 2002 ; 94 : 902-10.
    • (2002) Cancer , vol.94 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3    Biglietto, M.4    Rabitti, P.5    Uomo, G.6
  • 31
    • 33748445708 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
    • Heinemann V, Quietzsch D, Gieseler F, Gonnermann M, Schonekas H, Rost A, et al. Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 2006 ; 24 : 3946-52.
    • (2006) J Clin Oncol , vol.24 , pp. 3946-3952
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3    Gonnermann, M.4    Schonekas, H.5    Rost, A.6
  • 32
    • 0037087787 scopus 로고    scopus 로고
    • Gemcitabine combined with oxaliplatin in advanced pancreatic adenocarcinoma : Final results of a GERCOR multicenter phase II study
    • Louvet C, Andre T, Lledo G, Hammel P, Bleiberg H, Bouleuc C, et al. Gemcitabine combined with oxaliplatin in advanced pancreatic adenocarcinoma : final results of a GERCOR multicenter phase II study. J Clin Oncol 2002 ; 20 : 1512-8.
    • (2002) J Clin Oncol , vol.20 , pp. 1512-1518
    • Louvet, C.1    Andre, T.2    Lledo, G.3    Hammel, P.4    Bleiberg, H.5    Bouleuc, C.6
  • 33
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer : Results of a Gercor and Giscad phase III trial
    • Louvet C, Labianca R, Hammel P, Lledo G, Zampino MG, Andre T, et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer : results of a Gercor and Giscad phase III trial. J Clin Oncol 2005 ; 23 : 3509-16.
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3    Lledo, G.4    Zampino, M.G.5    Andre, T.6
  • 34
    • 33746156371 scopus 로고    scopus 로고
    • Increased survival using platinum analog combined with gemcitabine as compared to gemcitabine single agent in advanced pancreatic cancer (APC): Pooled analysis of two randomised trials, the Gercor/Giscad Intergroup Study and a German Multicenter Study
    • Louvet C, Hincke A, Labianca R, Heinemann V. Increased survival using platinum analog combined with gemcitabine as compared to gemcitabine single agent in advanced pancreatic cancer (APC): pooled analysis of two randomised trials, the Gercor/Giscad Intergroup Study and a German Multicenter Study. J Clin Oncol 2006 ; 24(18 suppl) : 4003.
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL. , pp. 4003
    • Louvet, C.1    Hincke, A.2    Labianca, R.3    Heinemann, V.4
  • 35
    • 34547774656 scopus 로고    scopus 로고
    • Randomized comparison of capecitabine plus oxaliplatin versus capecitabine plus gemcitabine versus gemcitabine plus oxaliplatin in advanced pancreatic cancer
    • Heinemann V, Hoehler T, Seipelt G, Wein A, Golf A, Mahlberg R, et al. Randomized comparison of capecitabine plus oxaliplatin versus capecitabine plus gemcitabine versus gemcitabine plus oxaliplatin in advanced pancreatic cancer. Eur J Cancer Suppl 2005 ; 3 : 205.
    • (2005) Eur J Cancer Suppl , vol.3 , pp. 205
    • Heinemann, V.1    Hoehler, T.2    Seipelt, G.3    Wein, A.4    Golf, A.5    Mahlberg, R.6
  • 36
    • 34547786128 scopus 로고    scopus 로고
    • Poplin E, Levy DE, Berlin J, Rothenberg ML, O'Dwyer PJ, Cella D, et al. Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion [FDR]) versus gemcitabine + oxaliplatin (Gemox) in patients with advanced pancreatic cancer (E6201). J Clin Oncol 2006 ; 24 : LBA4004.
    • Poplin E, Levy DE, Berlin J, Rothenberg ML, O'Dwyer PJ, Cella D, et al. Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion [FDR]) versus gemcitabine + oxaliplatin (Gemox) in patients with advanced pancreatic cancer (E6201). J Clin Oncol 2006 ; 24 : LBA4004.
  • 37
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • Rocha Lima CM, Green MR, Rotche R, Miller WH, Jeffrey GM, Cisar LA, et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 2004 ; 22 : 3776-83.
    • (2004) J Clin Oncol , vol.22 , pp. 3776-3783
    • Rocha Lima, C.M.1    Green, M.R.2    Rotche, R.3    Miller, W.H.4    Jeffrey, G.M.5    Cisar, L.A.6
  • 38
    • 33748297529 scopus 로고    scopus 로고
    • A multicenter phase III trial comparing irinotecan-gemcitabine with gemcitabine monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer
    • Stathopoulos GP, Syrigos K, Aravantinos G, Polyzos A, Papakotoulas P, Fountzilas G, et al. A multicenter phase III trial comparing irinotecan-gemcitabine with gemcitabine monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer. Br J Cancer 2006 ; 95 : 587-92.
    • (2006) Br J Cancer , vol.95 , pp. 587-592
    • Stathopoulos, G.P.1    Syrigos, K.2    Aravantinos, G.3    Polyzos, A.4    Papakotoulas, P.5    Fountzilas, G.6
  • 39
    • 16444372799 scopus 로고    scopus 로고
    • A randomized phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas cancer
    • Richards DA, Kindler HL, Oettle H, Ramanathan RK, Van Laethem JL, Peeters M, et al. A randomized phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas cancer. J Clin Oncol 2004 ; 22 : 4007.
    • (2004) J Clin Oncol , vol.22 , pp. 4007
    • Richards, D.A.1    Kindler, H.L.2    Oettle, H.3    Ramanathan, R.K.4    Van Laethem, J.L.5    Peeters, M.6
  • 40
    • 16444384413 scopus 로고    scopus 로고
    • A randomized phase III trial of DX-8951f (exatecan mesylate ; DX) and gemcitabine (GEM) vs. gemcitabine alone in advanced pancreatic cancer
    • O' Reilly EM, Abou-Alfa GK, Letourneau R, Harker WG, Modiano M, Hurwitz H, et al. A randomized phase III trial of DX-8951f (exatecan mesylate ; DX) and gemcitabine (GEM) vs. gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 2004 ; 22 : 4006.
    • (2004) J Clin Oncol , vol.22 , pp. 4006
    • O' Reilly, E.M.1    Abou-Alfa, G.K.2    Letourneau, R.3    Harker, W.G.4    Modiano, M.5    Hurwitz, H.6
  • 41
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, van de Velde H, Karasek P, Oettle H, Vervenne WL, Szawlowski A, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004 ; 22 : 1430-8.
    • (2004) J Clin Oncol , vol.22 , pp. 1430-1438
    • Van Cutsem, E.1    van de Velde, H.2    Karasek, P.3    Oettle, H.4    Vervenne, W.L.5    Szawlowski, A.6
  • 42
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, Brown PD, Baillet M, Buckels JA. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002 ; 87 : 161-7.
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 43
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, Figer A, Hecht J, Gallinger S, et al. Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007 ; 25 : 1960-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.5    Gallinger, S.6
  • 47
    • 0032907615 scopus 로고    scopus 로고
    • Two consecutive phase II studies of 5-fluorouracil/ leucovorin/mitomycin C and of gemcitabine in patients with advanced biliary cancer
    • Raderer M, Hejna MH, Valencak JB, Kornek GV, Weinlander GS, Bareck E, et al. Two consecutive phase II studies of 5-fluorouracil/ leucovorin/mitomycin C and of gemcitabine in patients with advanced biliary cancer. Oncology 1999 ; 56 : 177-80.
    • (1999) Oncology , vol.56 , pp. 177-180
    • Raderer, M.1    Hejna, M.H.2    Valencak, J.B.3    Kornek, G.V.4    Weinlander, G.S.5    Bareck, E.6
  • 48
    • 0033373618 scopus 로고    scopus 로고
    • Gemcitabine for the treatment of advanced biliary tract carcinomas : Evaluation of two different dose regimens
    • Valencak J, Kornek GV, Raderer M, Ulrich-Pur H, Krauss G, Greul R, et al. Gemcitabine for the treatment of advanced biliary tract carcinomas : evaluation of two different dose regimens. Onkologie 1999 ; 22 : 498-501.
    • (1999) Onkologie , vol.22 , pp. 498-501
    • Valencak, J.1    Kornek, G.V.2    Raderer, M.3    Ulrich-Pur, H.4    Krauss, G.5    Greul, R.6
  • 49
    • 0035108122 scopus 로고    scopus 로고
    • Phase II trial of two-weekly gemcitabine in patients with advanced biliary tract cancer
    • Penz M, Kornek GV, Raderer M, Ulrich-Pur H, Fiebiger W, Lenauer A, et al. Phase II trial of two-weekly gemcitabine in patients with advanced biliary tract cancer. Ann Oncol 2001 ; 12 : 183-6.
    • (2001) Ann Oncol , vol.12 , pp. 183-186
    • Penz, M.1    Kornek, G.V.2    Raderer, M.3    Ulrich-Pur, H.4    Fiebiger, W.5    Lenauer, A.6
  • 51
    • 0037971086 scopus 로고    scopus 로고
    • A phase II trial of gemcitabine in the treatment of advanced bile duct and periampullary carcinomas
    • Lin MH, Chen JS, Chen HH, Su WC. A phase II trial of gemcitabine in the treatment of advanced bile duct and periampullary carcinomas. Chemotherapy 2003 ; 49 : 154-8.
    • (2003) Chemotherapy , vol.49 , pp. 154-158
    • Lin, M.H.1    Chen, J.S.2    Chen, H.H.3    Su, W.C.4
  • 53
    • 10044298378 scopus 로고    scopus 로고
    • A phase II trial of fixed dose rate gemcitabine in patients with advanced biliary tree carcinoma
    • Eng C, Ramanathan RK, Wong MK, Remick SC, Dai L, Wade-Oliver KT, et al. A phase II trial of fixed dose rate gemcitabine in patients with advanced biliary tree carcinoma. Am J Clin Oncol 2004 ; 27 : 565-9.
    • (2004) Am J Clin Oncol , vol.27 , pp. 565-569
    • Eng, C.1    Ramanathan, R.K.2    Wong, M.K.3    Remick, S.C.4    Dai, L.5    Wade-Oliver, K.T.6
  • 54
    • 15044354629 scopus 로고    scopus 로고
    • Single-agent gemcitabine in the treatment of advanced biliary tract cancers : A phase II study
    • Park JS, Oh SY, Kim SH, Kwon HC, Kim JS, Jin-Kim H, et al. Single-agent gemcitabine in the treatment of advanced biliary tract cancers : a phase II study. Jpn J Clin Oncol 2005 ; 35 : 68-73.
    • (2005) Jpn J Clin Oncol , vol.35 , pp. 68-73
    • Park, J.S.1    Oh, S.Y.2    Kim, S.H.3    Kwon, H.C.4    Kim, J.S.5    Jin-Kim, H.6
  • 55
    • 26944433487 scopus 로고    scopus 로고
    • Phase II trial of weekly 24-hour infusion of gemcitabine in patients with advanced gallbladder and biliary tract carcinoma
    • Von Delius S, Lersch C, Schulte-Frohlinde E, Mayr M, Schmid RM, Eckel F. Phase II trial of weekly 24-hour infusion of gemcitabine in patients with advanced gallbladder and biliary tract carcinoma. BMC Cancer 2005 ; 5 : 61.
    • (2005) BMC Cancer , vol.5 , pp. 61
    • Von Delius, S.1    Lersch, C.2    Schulte-Frohlinde, E.3    Mayr, M.4    Schmid, R.M.5    Eckel, F.6
  • 59
    • 0033791494 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine in patients with previously untreated metastatic cancer of the esophagus or gastroesophageal junction
    • Sandler AB, Kindler HL, Einhorn LH, Mitchell E, Masters G, Kraut M, et al. Phase II trial of gemcitabine in patients with previously untreated metastatic cancer of the esophagus or gastroesophageal junction. Ann Oncol 2000 ; 11 : 1161-4.
    • (2000) Ann Oncol , vol.11 , pp. 1161-1164
    • Sandler, A.B.1    Kindler, H.L.2    Einhorn, L.H.3    Mitchell, E.4    Masters, G.5    Kraut, M.6
  • 60
    • 25444506891 scopus 로고    scopus 로고
    • A phase II trial of gemcitabine, 5-fluorouracil and leucovorin in advanced esophageal carcinoma
    • Morgan-Meadows S, Mulkerin D, Berlin JD, Kim K, Bailey H, Saphner T, et al. A phase II trial of gemcitabine, 5-fluorouracil and leucovorin in advanced esophageal carcinoma. Oncology 2005 ; 69 : 130-4.
    • (2005) Oncology , vol.69 , pp. 130-134
    • Morgan-Meadows, S.1    Mulkerin, D.2    Berlin, J.D.3    Kim, K.4    Bailey, H.5    Saphner, T.6
  • 61
    • 33645790827 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine plus irinotecan in patients with esophageal cancer : A Southwest Oncology Group (Swog) trial
    • Williamson SK, McCoy SA, Gandara DR, Dakhil SR, Yost KJ, Paradelo JC, et al. Phase II trial of gemcitabine plus irinotecan in patients with esophageal cancer : a Southwest Oncology Group (Swog) trial. Am J Clin Oncol 2006 ; 29 : 116-22.
    • (2006) Am J Clin Oncol , vol.29 , pp. 116-122
    • Williamson, S.K.1    McCoy, S.A.2    Gandara, D.R.3    Dakhil, S.R.4    Yost, K.J.5    Paradelo, J.C.6
  • 64
    • 0031022803 scopus 로고    scopus 로고
    • Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer
    • Webb A, Cunningham D, Scarffe JH, Harper P, Norman A, Joffe JK, et al. Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer. J Clin Oncol 1997 ; 15 : 261-7.
    • (1997) J Clin Oncol , vol.15 , pp. 261-267
    • Webb, A.1    Cunningham, D.2    Scarffe, J.H.3    Harper, P.4    Norman, A.5    Joffe, J.K.6
  • 65
    • 0027955097 scopus 로고
    • Phase II trial of gemcitabine in patients with advanced gastric cancer
    • Christman K, Kelsen D, Saltz L, Tarassoff PG. Phase II trial of gemcitabine in patients with advanced gastric cancer. Cancer 1994 ; 73 : 5-7.
    • (1994) Cancer , vol.73 , pp. 5-7
    • Christman, K.1    Kelsen, D.2    Saltz, L.3    Tarassoff, P.G.4
  • 66
    • 0028245160 scopus 로고
    • Gemcitabine in patients with advanced malignant melanoma or gastric cancer : Phase II studies of the EORTC Early Clinical Trials Group
    • Sessa C, Aamdal S, Wolff I, Eppelbaum R, Smyth JF, Sulkes A, et al. Gemcitabine in patients with advanced malignant melanoma or gastric cancer : phase II studies of the EORTC Early Clinical Trials Group. Ann Oncol 1994 ; 5 : 471-2.
    • (1994) Ann Oncol , vol.5 , pp. 471-472
    • Sessa, C.1    Aamdal, S.2    Wolff, I.3    Eppelbaum, R.4    Smyth, J.F.5    Sulkes, A.6
  • 68
    • 34547818745 scopus 로고    scopus 로고
    • Palliative chemotherapy with gemcitabine and carboplatin in metastasic and unresectable gastric cancer (UGC) : Phase II study
    • La Garza JD, Calderillo G, Gallardo D, Sanchez B, Barajas J, Onate L. Palliative chemotherapy with gemcitabine and carboplatin in metastasic and unresectable gastric cancer (UGC) : phase II study. Proc Am Soc Clin Oncol 2002.
    • (2002) Proc Am Soc Clin Oncol
    • La Garza, J.D.1    Calderillo, G.2    Gallardo, D.3    Sanchez, B.4    Barajas, J.5    Onate, L.6
  • 69
    • 26444591479 scopus 로고    scopus 로고
    • Gemcitabine (GEM) plus oxaliplatin, folinic acid, and 5-fluorouracil (Folfox-4) in patients with advanced gastric cancer
    • Correale P, Fulfaro F, Marsili S, Cicero G, Bajardi E, Intrivici C, et al. Gemcitabine (GEM) plus oxaliplatin, folinic acid, and 5-fluorouracil (Folfox-4) in patients with advanced gastric cancer. Cancer Chemother Pharmacol 2005 ; 56 : 563-8.
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 563-568
    • Correale, P.1    Fulfaro, F.2    Marsili, S.3    Cicero, G.4    Bajardi, E.5    Intrivici, C.6
  • 70
    • 0031014484 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma
    • Bruix J. Treatment of hepatocellular carcinoma. Hepatology 1997 ; 25 : 259-62.
    • (1997) Hepatology , vol.25 , pp. 259-262
    • Bruix, J.1
  • 71
    • 0033066135 scopus 로고    scopus 로고
    • A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire
    • Chevret S, Trinchet JC, Mathieu D, Rached AA, Beaugrand M, Chastang C. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire. J Hepatol 1999 ; 31 : 133-41.
    • (1999) J Hepatol , vol.31 , pp. 133-141
    • Chevret, S.1    Trinchet, J.C.2    Mathieu, D.3    Rached, A.A.4    Beaugrand, M.5    Chastang, C.6
  • 72
    • 0037096866 scopus 로고    scopus 로고
    • A phase II trial of gemcitabine in patients with advanced hepatocellular carcinoma
    • Fuchs CS, Clark JW, Ryan DP, Kulke MH, Kim H, Earle CC, et al. A phase II trial of gemcitabine in patients with advanced hepatocellular carcinoma. Cancer 2002 ; 94 : 3186-91.
    • (2002) Cancer , vol.94 , pp. 3186-3191
    • Fuchs, C.S.1    Clark, J.W.2    Ryan, D.P.3    Kulke, M.H.4    Kim, H.5    Earle, C.C.6
  • 73
    • 0346752536 scopus 로고    scopus 로고
    • Prospective randomised phase II study of gemcitabine at standard or fixed dose rate schedule in unresectable hepatocellular carcinoma
    • Guan Z, Wang Y, Maoleekoonpairoj S, Chen Z, Kim WS, Ratanatharathorn V, et al. Prospective randomised phase II study of gemcitabine at standard or fixed dose rate schedule in unresectable hepatocellular carcinoma. Br J Cancer 2003 ; 89 : 1865-9.
    • (2003) Br J Cancer , vol.89 , pp. 1865-1869
    • Guan, Z.1    Wang, Y.2    Maoleekoonpairoj, S.3    Chen, Z.4    Kim, W.S.5    Ratanatharathorn, V.6
  • 75
    • 0034663193 scopus 로고    scopus 로고
    • Phase II study of gemcitabine in patients with advanced hepatocellular carcinoma
    • Yang TS, Lin YC, Chen JS, Wang HM, Wang CH. Phase II study of gemcitabine in patients with advanced hepatocellular carcinoma. Cancer 2000 ; 89 : 750-6.
    • (2000) Cancer , vol.89 , pp. 750-756
    • Yang, T.S.1    Lin, Y.C.2    Chen, J.S.3    Wang, H.M.4    Wang, C.H.5
  • 76
    • 0036861915 scopus 로고    scopus 로고
    • Gemcitabine and doxorubicin for the treatment of patients with advanced hepatocellular carcinoma : A phase I-II trial
    • Yang TS, Wang CH, Hsieh RK, Chen JS, Fung MC. Gemcitabine and doxorubicin for the treatment of patients with advanced hepatocellular carcinoma : a phase I-II trial. Ann Oncol 2002 ; 13 : 1771-8.
    • (2002) Ann Oncol , vol.13 , pp. 1771-1778
    • Yang, T.S.1    Wang, C.H.2    Hsieh, R.K.3    Chen, J.S.4    Fung, M.C.5
  • 77
    • 29044442874 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin-based combination chemotherapy as salvage treatment in patients with advanced hepatocellular carcinoma
    • Poh SB, Bai LY, Chen PM. Pegylated liposomal doxorubicin-based combination chemotherapy as salvage treatment in patients with advanced hepatocellular carcinoma. Am J Clin Oncol 2005 ; 28 : 540-6.
    • (2005) Am J Clin Oncol , vol.28 , pp. 540-546
    • Poh, S.B.1    Bai, L.Y.2    Chen, P.M.3
  • 78
    • 33645633809 scopus 로고    scopus 로고
    • A phase II study of gemcitabine and cisplatin in patients with advanced hepatocellular carcinoma
    • Parikh PM, Fuloria J, Babu G, Doval DC, Awasthy BS, Pai VR, et al. A phase II study of gemcitabine and cisplatin in patients with advanced hepatocellular carcinoma. Trop Gastroenterol 2005 ; 26 : 115-8.
    • (2005) Trop Gastroenterol , vol.26 , pp. 115-118
    • Parikh, P.M.1    Fuloria, J.2    Babu, G.3    Doval, D.C.4    Awasthy, B.S.5    Pai, V.R.6
  • 79
    • 0344667601 scopus 로고    scopus 로고
    • Gemcitabine plus oxaliplatin for patients with advanced hepatocellular carcinoma using two different schedules
    • Taieb J, Bonyhay L, Golli L, Ducreux M, Boleslawski E, Tigaud JM, et al. Gemcitabine plus oxaliplatin for patients with advanced hepatocellular carcinoma using two different schedules. Cancer 2003 ; 98 : 2664-70.
    • (2003) Cancer , vol.98 , pp. 2664-2670
    • Taieb, J.1    Bonyhay, L.2    Golli, L.3    Ducreux, M.4    Boleslawski, E.5    Tigaud, J.M.6
  • 80
    • 34247152286 scopus 로고    scopus 로고
    • Gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma : Results of a phase II study
    • Taieb J, Mansourbakhr T, Ducreux M, Bonyhay L, De Baere T, Delgado M, et al. Gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma : results of a phase II study. J Clin Oncol 2004 ; 22 : 4086.
    • (2004) J Clin Oncol , vol.22 , pp. 4086
    • Taieb, J.1    Mansourbakhr, T.2    Ducreux, M.3    Bonyhay, L.4    De Baere, T.5    Delgado, M.6
  • 81
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Blaszkowsky LS, Ryan DP, Clark JW, Muzikansky A, Horgan K, et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006 ; 24 : 1898-903.
    • (2006) J Clin Oncol , vol.24 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3    Clark, J.W.4    Muzikansky, A.5    Horgan, K.6
  • 82
    • 2642573446 scopus 로고    scopus 로고
    • A novel biweekly multidrug regimen of gemcitabine, oxaliplatin, 5-fluofouracil (5-FU), and folinic acid (FA) in pretreated patients with advanced colorectal carcinoma
    • Correale P, Messinese S, Caraglia M, Marsili S, Piccolomini A, Petrioli R, et al. A novel biweekly multidrug regimen of gemcitabine, oxaliplatin, 5-fluofouracil (5-FU), and folinic acid (FA) in pretreated patients with advanced colorectal carcinoma. Br J Cancer 2004 ; 90 : 1710-4.
    • (2004) Br J Cancer , vol.90 , pp. 1710-1714
    • Correale, P.1    Messinese, S.2    Caraglia, M.3    Marsili, S.4    Piccolomini, A.5    Petrioli, R.6
  • 83
    • 33644789357 scopus 로고    scopus 로고
    • Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus Folfox 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients
    • Correale P, Cusi MG, Tsang KY, Del Vecchio MT, Marsili S, Placa ML, et al. Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus Folfox 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients. J Clin Oncol 2005 ; 23 : 8950-8.
    • (2005) J Clin Oncol , vol.23 , pp. 8950-8958
    • Correale, P.1    Cusi, M.G.2    Tsang, K.Y.3    Del Vecchio, M.T.4    Marsili, S.5    Placa, M.L.6
  • 84
    • 34547776332 scopus 로고    scopus 로고
    • Phase II srudy of fixed dose rate gemcitabine in patients with pretreated advanced colorectal cancer
    • Chong G, Starling N, Norman AR, Brown G, Thomas J, Ross PJ, et al. Phase II srudy of fixed dose rate gemcitabine in patients with pretreated advanced colorectal cancer. J Clin Oncol 2006 ; 24 : 13558.
    • (2006) J Clin Oncol , vol.24 , pp. 13558
    • Chong, G.1    Starling, N.2    Norman, A.R.3    Brown, G.4    Thomas, J.5    Ross, P.J.6
  • 85
    • 34547757988 scopus 로고    scopus 로고
    • Gemcitabine as salvage therapy in patients with advanced colorectal cancer refractory to 5-fluorouracil, irinotecan and oxaliplatin
    • Lonardi S, Paris MK, Stefani M, Caroti C, D'Amico M, Jirillo A, et al. Gemcitabine as salvage therapy in patients with advanced colorectal cancer refractory to 5-fluorouracil, irinotecan and oxaliplatin. J Clin Oncol 2004 ; 22 : 3577.
    • (2004) J Clin Oncol , vol.22 , pp. 3577
    • Lonardi, S.1    Paris, M.K.2    Stefani, M.3    Caroti, C.4    D'Amico, M.5    Jirillo, A.6
  • 86
    • 33646788778 scopus 로고    scopus 로고
    • Multicenter phase II study of gemcitabine and oxaliplatin as second-line chemotherapy in colorectal cancer patients pretreated with 5-fluorouracil plus irinotecan
    • Ziras N, Potamianou A, Varthalitis I, Syrigos K, Tsousis S, Boukovinas I, et al. Multicenter phase II study of gemcitabine and oxaliplatin as second-line chemotherapy in colorectal cancer patients pretreated with 5-fluorouracil plus irinotecan. Oncology 2006 ; 70 : 106-14.
    • (2006) Oncology , vol.70 , pp. 106-114
    • Ziras, N.1    Potamianou, A.2    Varthalitis, I.3    Syrigos, K.4    Tsousis, S.5    Boukovinas, I.6
  • 87
    • 34547743185 scopus 로고    scopus 로고
    • Capecitabine plus gemcitabine in heavily pre-treated colorectal cancer. Results of an exploratory study
    • Fernandez Y, Vieitez JM, Fra J, Palacio I, Mareque B, Una E, et al. Capecitabine plus gemcitabine in heavily pre-treated colorectal cancer. Results of an exploratory study. J Clin Oncol 2004 ; 22 : 3679.
    • (2004) J Clin Oncol , vol.22 , pp. 3679
    • Fernandez, Y.1    Vieitez, J.M.2    Fra, J.3    Palacio, I.4    Mareque, B.5    Una, E.6
  • 88
    • 0035887036 scopus 로고    scopus 로고
    • Treatment of inoperable and/or metastatic biliary tree carcinomas with single-agent gemcitabine or in combination with levofolinic acid and infusional fluorouracil : Results of a multicenter phase II study
    • Gebbia V, Giuliani F, Maiello E, Colucci G, Verderame F, Borsellino N, et al. Treatment of inoperable and/or metastatic biliary tree carcinomas with single-agent gemcitabine or in combination with levofolinic acid and infusional fluorouracil : results of a multicenter phase II study. J Clin Oncol 2001 ; 19 : 4089-91.
    • (2001) J Clin Oncol , vol.19 , pp. 4089-4091
    • Gebbia, V.1    Giuliani, F.2    Maiello, E.3    Colucci, G.4    Verderame, F.5    Borsellino, N.6
  • 89
    • 4644359855 scopus 로고    scopus 로고
    • Gemcitabine combined with oxaliplatin in advanced biliary tract adenocarcinoma : A Gercor study
    • Andre T, Tournigand C, Rosmorduc O, Provent S, Maindrault-Goebel F, Avenin D, et al. Gemcitabine combined with oxaliplatin in advanced biliary tract adenocarcinoma : a Gercor study. Ann Oncol 2004 ; 15 : 1339-43.
    • (2004) Ann Oncol , vol.15 , pp. 1339-1343
    • Andre, T.1    Tournigand, C.2    Rosmorduc, O.3    Provent, S.4    Maindrault-Goebel, F.5    Avenin, D.6
  • 90
    • 28344437253 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin and gemcitabine first line chemotherapy in patients with advanced biliary tract cancers
    • Gebbia N, Verderame F, Di Leo R, Santangelo D, Cicero G, Valerio MR, et al. A phase II study of oxaliplatin and gemcitabine first line chemotherapy in patients with advanced biliary tract cancers. J Clin Oncol 2005 ; 23 : 4132.
    • (2005) J Clin Oncol , vol.23 , pp. 4132
    • Gebbia, N.1    Verderame, F.2    Di Leo, R.3    Santangelo, D.4    Cicero, G.5    Valerio, M.R.6
  • 91
    • 33750914080 scopus 로고    scopus 로고
    • Gemcitabine and oxaliplatin (Gemox) in advanced/unresectable gall baldder cancer : A phase II study
    • Sharma A, Raina V, Shukla NK, Deo SV. Gemcitabine and oxaliplatin (Gemox) in advanced/unresectable gall baldder cancer : a phase II study. J Clin Oncol 2006 ; 24 : 14027.
    • (2006) J Clin Oncol , vol.24 , pp. 14027
    • Sharma, A.1    Raina, V.2    Shukla, N.K.3    Deo, S.V.4
  • 92
    • 33749367313 scopus 로고    scopus 로고
    • Outpatient chemotherapy with gemcitabine and oxaliplatin in patients with biliary tract cancer
    • Harder J, Riecken B, Kummer O, Lohrmann C, Otto F, Usadel H, et al. Outpatient chemotherapy with gemcitabine and oxaliplatin in patients with biliary tract cancer. Br J Cancer 2006 ; 95 : 848-52.
    • (2006) Br J Cancer , vol.95 , pp. 848-852
    • Harder, J.1    Riecken, B.2    Kummer, O.3    Lohrmann, C.4    Otto, F.5    Usadel, H.6
  • 93
    • 34547785592 scopus 로고    scopus 로고
    • Exibit: An international multicenter phase II trial of gemcitabine and oxaliplatin (Gemox) in patients with advanced biliary tract cancer
    • Andre T, Reyes-Vidal JM, Fartoux L, Ross P, Leslie M, Rosmorduc O, et al. Exibit: An international multicenter phase II trial of gemcitabine and oxaliplatin (Gemox) in patients with advanced biliary tract cancer. J Clin Oncol 2006 ; 24(18 suppl) : 4135.
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL. , pp. 4135
    • Andre, T.1    Reyes-Vidal, J.M.2    Fartoux, L.3    Ross, P.4    Leslie, M.5    Rosmorduc, O.6
  • 94
    • 2442423894 scopus 로고    scopus 로고
    • A phase II study of gemcitabine and cisplatin in chemotherapy-naive, unresectable gall bladder cancer
    • Doval DC, Sekhon JS, Gupta SK, Fuloria J, Shukla VK, Gupta S, et al. A phase II study of gemcitabine and cisplatin in chemotherapy-naive, unresectable gall bladder cancer. Br J Cancer 2004 ; 90 : 1516-20.
    • (2004) Br J Cancer , vol.90 , pp. 1516-1520
    • Doval, D.C.1    Sekhon, J.S.2    Gupta, S.K.3    Fuloria, J.4    Shukla, V.K.5    Gupta, S.6
  • 95
    • 14644410398 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma
    • Thongprasert S, Napapan S, Charoentum C, Moonprakan S. Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma. Ann Oncol 2005 ; 16 : 279-81.
    • (2005) Ann Oncol , vol.16 , pp. 279-281
    • Thongprasert, S.1    Napapan, S.2    Charoentum, C.3    Moonprakan, S.4
  • 97
    • 33644842475 scopus 로고    scopus 로고
    • A phase II study of gemcitabine and cisplatin in advanced biliary tract cancer
    • Kim ST, Park JO, Lee J, Lee KT, Lee JK, Choi SH, et al. A phase II study of gemcitabine and cisplatin in advanced biliary tract cancer. Cancer 2006 ; 106 : 1339-46.
    • (2006) Cancer , vol.106 , pp. 1339-1346
    • Kim, S.T.1    Park, J.O.2    Lee, J.3    Lee, K.T.4    Lee, J.K.5    Choi, S.H.6
  • 99
    • 33745616822 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin for inoperable and/or metastatic biliary tree carcinomas : A multicenter phase II study of the Gruppo Oncologico dell'Italia Meridionale (GOIM)
    • Giuliani F, Gebbia V, Maiello E, Borsellino N, Bajardi E, Colucci G. Gemcitabine and cisplatin for inoperable and/or metastatic biliary tree carcinomas : a multicenter phase II study of the Gruppo Oncologico dell'Italia Meridionale (GOIM). Ann Oncol 2006 ; 17 : 73-7.
    • (2006) Ann Oncol , vol.17 , pp. 73-77
    • Giuliani, F.1    Gebbia, V.2    Maiello, E.3    Borsellino, N.4    Bajardi, E.5    Colucci, G.6
  • 100
    • 2642516411 scopus 로고    scopus 로고
    • Weekly gemcitabine plus 24-h infusion of high-dose 5-fluorouracil/leucovorin for locally advanced or metastatic carcinoma of the biliary tract
    • Hsu C, Shen YC, Yang CH, Yeh KH, Lu YS, Hsu CH, et al. Weekly gemcitabine plus 24-h infusion of high-dose 5-fluorouracil/leucovorin for locally advanced or metastatic carcinoma of the biliary tract. Br J Cancer 2004 ; 90 : 1715-9.
    • (2004) Br J Cancer , vol.90 , pp. 1715-1719
    • Hsu, C.1    Shen, Y.C.2    Yang, C.H.3    Yeh, K.H.4    Lu, Y.S.5    Hsu, C.H.6
  • 101
    • 2642567052 scopus 로고    scopus 로고
    • Gemcitabine concurrent with continuous infusional 5-fluorouracil in advanced biliary cancers : A review of the Princess Margaret Hospital experience
    • Knox JJ, Hedley D, Oza A, Siu LL, Pond GR, Moore MJ. Gemcitabine concurrent with continuous infusional 5-fluorouracil in advanced biliary cancers : a review of the Princess Margaret Hospital experience. Ann Oncol 2004 ; 15 : 770-4.
    • (2004) Ann Oncol , vol.15 , pp. 770-774
    • Knox, J.J.1    Hedley, D.2    Oza, A.3    Siu, L.L.4    Pond, G.R.5    Moore, M.J.6
  • 102
    • 10844226636 scopus 로고    scopus 로고
    • Gemcitabine, 5-fluorouracil, and leucovorin in advanced biliary tract and gallbladder carcinoma : A North Central Cancer Treatment Group phase II trial
    • Alberts SR, Al-Khatib H, Mahoney MR, Burgart L, Cera PJ, Flynn PJ, et al. Gemcitabine, 5-fluorouracil, and leucovorin in advanced biliary tract and gallbladder carcinoma : a North Central Cancer Treatment Group phase II trial. Cancer 2005 ; 103 : 111-8.
    • (2005) Cancer , vol.103 , pp. 111-118
    • Alberts, S.R.1    Al-Khatib, H.2    Mahoney, M.R.3    Burgart, L.4    Cera, P.J.5    Flynn, P.J.6
  • 103
    • 20244371852 scopus 로고    scopus 로고
    • Combining gemcitabine and capecitabine in patients with advanced biliary cancer : A phase II trial
    • Knox JJ, Hedley D, Oza A, Feld R, Siu LL, Chen E, et al. Combining gemcitabine and capecitabine in patients with advanced biliary cancer : a phase II trial. J Clin Oncol 2005 ; 23 : 2332-8.
    • (2005) J Clin Oncol , vol.23 , pp. 2332-2338
    • Knox, J.J.1    Hedley, D.2    Oza, A.3    Feld, R.4    Siu, L.L.5    Chen, E.6
  • 104
    • 34547810433 scopus 로고    scopus 로고
    • Phase II rrial of gemcitabine plus capecitabine in patients with advanced biliary tract cancer
    • Chang HM, Ryu MH, Lee JL, Kim TW, Lee JS, Kim WK, et al. Phase II rrial of gemcitabine plus capecitabine in patients with advanced biliary tract cancer. J Clin Oncol 2005 ; 23 : 4173.
    • (2005) J Clin Oncol , vol.23 , pp. 4173
    • Chang, H.M.1    Ryu, M.H.2    Lee, J.L.3    Kim, T.W.4    Lee, J.S.5    Kim, W.K.6
  • 105
    • 29144480045 scopus 로고    scopus 로고
    • Capecitabine combined with gemcitabine as first-line treatment in patients with advanced/metastatic biliary tract carcinoma
    • Cho JY, Paik YH, Chang YS, Lee SJ, Lee DK, Song SY, et al. Capecitabine combined with gemcitabine as first-line treatment in patients with advanced/metastatic biliary tract carcinoma. Cancer 2005 ; 104 : 2753-8.
    • (2005) Cancer , vol.104 , pp. 2753-2758
    • Cho, J.Y.1    Paik, Y.H.2    Chang, Y.S.3    Lee, S.J.4    Lee, D.K.5    Song, S.Y.6
  • 106
    • 33750910197 scopus 로고    scopus 로고
    • SWOG S0202 : A phase II trial of gemcitabine and capecitabine in patients with unresectable or metastatic gallbladder cancer or cholangiocarcinoma
    • Iqbal S, McCoy S, Lenz HJ, Rivkin SE, Atkins JN, Blanke CD. SWOG S0202 : A phase II trial of gemcitabine and capecitabine in patients with unresectable or metastatic gallbladder cancer or cholangiocarcinoma. J Clin Oncol 2006 ; 24 : 4134.
    • (2006) J Clin Oncol , vol.24 , pp. 4134
    • Iqbal, S.1    McCoy, S.2    Lenz, H.J.3    Rivkin, S.E.4    Atkins, J.N.5    Blanke, C.D.6
  • 107
    • 0036021237 scopus 로고    scopus 로고
    • Outpatient therapy with gemcitabine and docetaxel for gallbladder, biliary, and cholangio-carcinomas
    • Kuhn R, Hribaschek A, Eichelmann K, Rudolph S, Fahlke J, Ridwelski K. Outpatient therapy with gemcitabine and docetaxel for gallbladder, biliary, and cholangio-carcinomas. Invest New Drugs 2002 ; 20 : 351-6.
    • (2002) Invest New Drugs , vol.20 , pp. 351-356
    • Kuhn, R.1    Hribaschek, A.2    Eichelmann, K.3    Rudolph, S.4    Fahlke, J.5    Ridwelski, K.6
  • 109
    • 1842555346 scopus 로고    scopus 로고
    • Mitomycin C in combination with capecitabine or biweekly high-dose gemcitabine in patients with advanced biliary tract cancer : A randomised phase II trial
    • Kornek GV, Schuell B, Laengle F, Gruenberger T, Penz M, Karall K, et al. Mitomycin C in combination with capecitabine or biweekly high-dose gemcitabine in patients with advanced biliary tract cancer : a randomised phase II trial. Ann Oncol 2004 ; 15 : 478-83.
    • (2004) Ann Oncol , vol.15 , pp. 478-483
    • Kornek, G.V.1    Schuell, B.2    Laengle, F.3    Gruenberger, T.4    Penz, M.5    Karall, K.6
  • 110
    • 27944438110 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and cisplatin in locally advanced/metastatic oesophageal cancer
    • Millar J, Scullin P, Morrison A, McClory B, Wall L, Cameron D, et al. Phase II study of gemcitabine and cisplatin in locally advanced/metastatic oesophageal cancer. Br J Cancer 2005 ; 93 : 1112-6.
    • (2005) Br J Cancer , vol.93 , pp. 1112-1116
    • Millar, J.1    Scullin, P.2    Morrison, A.3    McClory, B.4    Wall, L.5    Cameron, D.6
  • 111
    • 34547786608 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and cisplatin in previously untreated metastatic or recurrent advanced esophageal cancer : A Chinese esophageal cancer group
    • Huang J, Fan XQ, Chen L, Liu NA, Cai GR, Zhang RX, et al. Phase II study of gemcitabine and cisplatin in previously untreated metastatic or recurrent advanced esophageal cancer : a Chinese esophageal cancer group. J Clin Oncol 2006 ; 24 : 14015.
    • (2006) J Clin Oncol , vol.24 , pp. 14015
    • Huang, J.1    Fan, X.Q.2    Chen, L.3    Liu, N.A.4    Cai, G.R.5    Zhang, R.X.6
  • 112
    • 34547784555 scopus 로고    scopus 로고
    • CONKO-101 : Results of a multicenter phase II study of an outpatient regimen consisting out of gemcitabine, 5-FU (24h CI), folinic acid and cisplatin for patients with inoperable esophageal cancer
    • Stieler JM, Hilbig A, Pelzer U, Roll L, Dorken B, Riess H, et al. CONKO-101 : Results of a multicenter phase II study of an outpatient regimen consisting out of gemcitabine, 5-FU (24h CI), folinic acid and cisplatin for patients with inoperable esophageal cancer. J Clin Oncol 2006 ; 24 : 4066.
    • (2006) J Clin Oncol , vol.24 , pp. 4066
    • Stieler, J.M.1    Hilbig, A.2    Pelzer, U.3    Roll, L.4    Dorken, B.5    Riess, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.