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Volumn 27, Issue 4 B, 2007, Pages 2345-2352

Alterations of the p53, Rb and p27 tumor suppressor pathways in diffuse large B-cell lymphomas

Author keywords

Cell cycle; Diffuse large B cell lymphomas

Indexed keywords

CYCLIN A; DNA; KI 67 ANTIGEN; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 34547761368     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (16)

References (58)
  • 2
    • 0348108196 scopus 로고    scopus 로고
    • Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance
    • de Leval L and Harris NL : Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance. Histopathology 43: 509-528, 2003.
    • (2003) Histopathology , vol.43 , pp. 509-528
    • de Leval, L.1    Harris, N.L.2
  • 3
    • 1642499119 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma: Clinical implications of extranodal versus nodal presentation - a population-based study of 1575 cases
    • Moller MB, Pedersen NT and Christensen BE: Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation - a population-based study of 1575 cases. Br J Haematol 124: 151-159, 2004.
    • (2004) Br J Haematol , vol.124 , pp. 151-159
    • Moller, M.B.1    Pedersen, N.T.2    Christensen, B.E.3
  • 4
    • 0036884169 scopus 로고    scopus 로고
    • Lymphoid malignancies: The dark side of B-cell differentiation
    • Shaffer AL, Rosenwald A and Staudt LM: Lymphoid malignancies: the dark side of B-cell differentiation. Nat Rev Immunol 2: 920-932, 2002.
    • (2002) Nat Rev Immunol , vol.2 , pp. 920-932
    • Shaffer, A.L.1    Rosenwald, A.2    Staudt, L.M.3
  • 5
    • 0036440942 scopus 로고    scopus 로고
    • Molecular heterogeneity of diffuse large B-cell lymphoma: Implications for disease management and prognosis
    • Rossi D and Gaidano G: Molecular heterogeneity of diffuse large B-cell lymphoma: implications for disease management and prognosis. Hematology 7: 239-252, 2002.
    • (2002) Hematology , vol.7 , pp. 239-252
    • Rossi, D.1    Gaidano, G.2
  • 6
    • 0036724323 scopus 로고    scopus 로고
    • Cell kinetics and cell cycle regulation in lymphomas
    • Leoncini L, Lazzi S, Bellan C and Tosi P: Cell kinetics and cell cycle regulation in lymphomas. J Clin Pathol 55: 648-655, 2002.
    • (2002) J Clin Pathol , vol.55 , pp. 648-655
    • Leoncini, L.1    Lazzi, S.2    Bellan, C.3    Tosi, P.4
  • 7
  • 17
    • 0038509092 scopus 로고    scopus 로고
    • Growth regulation by p27 Kip1 is abrogated by multiple mechanisms in aggressive malignant lymphomas
    • Lin Z, Lim S and Lim MS: Growth regulation by p27 Kip1 is abrogated by multiple mechanisms in aggressive malignant lymphomas. Br J Haematol 121: 739-748, 2003.
    • (2003) Br J Haematol , vol.121 , pp. 739-748
    • Lin, Z.1    Lim, S.2    Lim, M.S.3
  • 18
    • 0344731443 scopus 로고    scopus 로고
    • Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression and P27/KIP1-cyclin D3 colocalization in tumor cells
    • Sanchez-Beato M, Camacho FI, Martinez-Montero JC, Saez AI, Villuendas R, Sanchez-Verde L, Garcia JF and Piris MA: Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression and P27/KIP1-cyclin D3 colocalization in tumor cells. Blood 94: 765-772, 1999.
    • (1999) Blood , vol.94 , pp. 765-772
    • Sanchez-Beato, M.1    Camacho, F.I.2    Martinez-Montero, J.C.3    Saez, A.I.4    Villuendas, R.5    Sanchez-Verde, L.6    Garcia, J.F.7    Piris, M.A.8
  • 19
    • 0032147113 scopus 로고    scopus 로고
    • Expression of cyclin E and the cyclin-dependent kinase inhibitor p27 in malignant lymphomas-prognostic implications
    • Erlanson M, Portin C, Linderholm B, Lindh J, Roos G and Landberg G: Expression of cyclin E and the cyclin-dependent kinase inhibitor p27 in malignant lymphomas-prognostic implications. Blood 92: 770-777, 1998.
    • (1998) Blood , vol.92 , pp. 770-777
    • Erlanson, M.1    Portin, C.2    Linderholm, B.3    Lindh, J.4    Roos, G.5    Landberg, G.6
  • 20
    • 0032710435 scopus 로고    scopus 로고
    • Oncoprotein MDM2 overexpression is associated with poor prognosis in distinct non-Hodgkin's lymphoma entities
    • Moller MB, Nielsen O and Pedersen NT: Oncoprotein MDM2 overexpression is associated with poor prognosis in distinct non-Hodgkin's lymphoma entities. Mod Pathol 12: 1010-1016, 1999.
    • (1999) Mod Pathol , vol.12 , pp. 1010-1016
    • Moller, M.B.1    Nielsen, O.2    Pedersen, N.T.3
  • 21
    • 0031835211 scopus 로고    scopus 로고
    • Loss of tumor suppressor gene expression in high grade but not in low grade non-Hodgkin's lymphomas
    • Geradts J, Andriko JW and Abbondanzo SL: Loss of tumor suppressor gene expression in high grade but not in low grade non-Hodgkin's lymphomas. Am J Clin Pathol 109: 669-674, 1998.
    • (1998) Am J Clin Pathol , vol.109 , pp. 669-674
    • Geradts, J.1    Andriko, J.W.2    Abbondanzo, S.L.3
  • 22
    • 0035417926 scopus 로고    scopus 로고
    • Frequent alterations of the pl4/ARF and p16/INK4a genes in primary central nervous system lymphomas
    • Nakamura M, Sakaki T, Hashimoto H, Nakase H, Oshida E, Shimada K and Konishi N: Frequent alterations of the pl4/ARF and p16/INK4a genes in primary central nervous system lymphomas. Cancer Res 61: 6335-6339, 2001.
    • (2001) Cancer Res , vol.61 , pp. 6335-6339
    • Nakamura, M.1    Sakaki, T.2    Hashimoto, H.3    Nakase, H.4    Oshida, E.5    Shimada, K.6    Konishi, N.7
  • 23
    • 0033013596 scopus 로고    scopus 로고
    • Aberrations of the p53 pathway components p53, mdm2 and CDKN2A appear independent in diffuse large B cell lymphoma
    • Moller MB, Ino Y, Gerdes AM, Skjodt K, Louis DN and Pedersen NT: Aberrations of the p53 pathway components p53, mdm2 and CDKN2A appear independent in diffuse large B cell lymphoma. Leukemia 13: 453-459, 1999.
    • (1999) Leukemia , vol.13 , pp. 453-459
    • Moller, M.B.1    Ino, Y.2    Gerdes, A.M.3    Skjodt, K.4    Louis, D.N.5    Pedersen, N.T.6
  • 24
    • 0034009592 scopus 로고    scopus 로고
    • Frequent disruption of the RB1 pathway in diffuse large B cell lymphoma: Prognostic significance of E2F-1 and p16 INK4A
    • Moller MB, Kania PW, Ino Y, Gerdes AM, Nielsen O, Louis DN, Skjodt K and Pedersen NT: Frequent disruption of the RB1 pathway in diffuse large B cell lymphoma: prognostic significance of E2F-1 and p16 INK4A. Leukemia 14: 898-904, 2000.
    • (2000) Leukemia , vol.14 , pp. 898-904
    • Moller, M.B.1    Kania, P.W.2    Ino, Y.3    Gerdes, A.M.4    Nielsen, O.5    Louis, D.N.6    Skjodt, K.7    Pedersen, N.T.8
  • 28
    • 0035163837 scopus 로고    scopus 로고
    • Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin A and cyclin B1 in diffuse large B-cell lymphomas
    • Bai M, Vlachonikolis J, Agnantis NJ, Tsanou E, Dimou S, Nicolaides C, Stefanaki S, Pavlidis N and Kanavaros P: Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin A and cyclin B1 in diffuse large B-cell lymphomas. Mod Pathol 14: 1105-1113, 2001.
    • (2001) Mod Pathol , vol.14 , pp. 1105-1113
    • Bai, M.1    Vlachonikolis, J.2    Agnantis, N.J.3    Tsanou, E.4    Dimou, S.5    Nicolaides, C.6    Stefanaki, S.7    Pavlidis, N.8    Kanavaros, P.9
  • 30
    • 0037082509 scopus 로고    scopus 로고
    • p14 (ARF) nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppresor pathways
    • Sanchez-Aguilera A, Sanchez-Beato M, Garcia JF, Prieto I, Pollan M and Piris MA: p14 (ARF) nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppresor pathways. Blood 99: 1411-1418, 2002.
    • (2002) Blood , vol.99 , pp. 1411-1418
    • Sanchez-Aguilera, A.1    Sanchez-Beato, M.2    Garcia, J.F.3    Prieto, I.4    Pollan, M.5    Piris, M.A.6
  • 32
    • 24144456978 scopus 로고    scopus 로고
    • Expression and prognostic implications of cell cycle regulatory molecules, p16, p21, p27, p14 and p53 in germinal center and non-germinal center B-like diffuse large B-cell lymphomas
    • Paik JH, Jeon YK, Park SS, Kim YA, Kim JE, Huh J, Lee SS, Kim WH and Kim CW: Expression and prognostic implications of cell cycle regulatory molecules, p16, p21, p27, p14 and p53 in germinal center and non-germinal center B-like diffuse large B-cell lymphomas. Histopathology 47: 281-291, 2005.
    • (2005) Histopathology , vol.47 , pp. 281-291
    • Paik, J.H.1    Jeon, Y.K.2    Park, S.S.3    Kim, Y.A.4    Kim, J.E.5    Huh, J.6    Lee, S.S.7    Kim, W.H.8    Kim, C.W.9
  • 33
    • 4644228483 scopus 로고    scopus 로고
    • Promoter hypermethylation and protein expression of the p16 gene: Analysis of 43 cases of B-cell primary gastric lymphomas from China
    • Huang Q, Ai L, Zhang ZY, Fan CY and Weiss LM: Promoter hypermethylation and protein expression of the p16 gene: analysis of 43 cases of B-cell primary gastric lymphomas from China. Mod Pathol 17: 416-422, 2004.
    • (2004) Mod Pathol , vol.17 , pp. 416-422
    • Huang, Q.1    Ai, L.2    Zhang, Z.Y.3    Fan, C.Y.4    Weiss, L.M.5
  • 34
    • 85014269563 scopus 로고    scopus 로고
    • Relationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: A preferential survivin-cyclin B link
    • Kuttler F, Valnet-Rabier MB, Angonin R, Ferrand C, Decininck E, Mougin C, Cahn JY and Fest T: Relationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: a preferential survivin-cyclin B link. Leukemia 16: 726-735, 2002.
    • (2002) Leukemia , vol.16 , pp. 726-735
    • Kuttler, F.1    Valnet-Rabier, M.B.2    Angonin, R.3    Ferrand, C.4    Decininck, E.5    Mougin, C.6    Cahn, J.Y.7    Fest, T.8
  • 35
    • 0037378003 scopus 로고    scopus 로고
    • Expression of cyclin D3 and cyclin E and identification of distinct clusters of proliferative activity and apoptosis status in diffuse large B-cell lymphomas
    • Bai M, Tsanou E, Agnantis NJ, Dimou D, Chaidos A, Skyrlas A, Dimou S, Vlychou M, Galani V and Kanavaros P: Expression of cyclin D3 and cyclin E and identification of distinct clusters of proliferative activity and apoptosis status in diffuse large B-cell lymphomas. Histol Histopathol 18: 449-457, 2003.
    • (2003) Histol Histopathol , vol.18 , pp. 449-457
    • Bai, M.1    Tsanou, E.2    Agnantis, N.J.3    Dimou, D.4    Chaidos, A.5    Skyrlas, A.6    Dimou, S.7    Vlychou, M.8    Galani, V.9    Kanavaros, P.10
  • 36
    • 0034660892 scopus 로고    scopus 로고
    • The Pezcoller lecture: Cancer cell cycles revisited
    • Sherr CJ: The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 60: 3689-3695, 2000.
    • (2000) Cancer Res , vol.60 , pp. 3689-3695
    • Sherr, C.J.1
  • 37
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres M and Barbacid M: To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 1: 222-231, 2001.
    • (2001) Nat Rev Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 38
    • 84991414027 scopus 로고    scopus 로고
    • Checking out the G2/M transition
    • Smits V and Medema R: Checking out the G2/M transition. Biochim Biophys Acta 1519: 1-12, 2001.
    • (2001) Biochim Biophys Acta , vol.1519 , pp. 1-12
    • Smits, V.1    Medema, R.2
  • 39
    • 0842324788 scopus 로고    scopus 로고
    • Recycling the cell cycle: Cyclins revisited
    • Murray AW: Recycling the cell cycle: cyclins revisited. Cell 116: 221-234, 2004.
    • (2004) Cell , vol.116 , pp. 221-234
    • Murray, A.W.1
  • 41
    • 0037142053 scopus 로고    scopus 로고
    • Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fischer RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, Lopez-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T and Staudt LM: The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. N Engl J Med 346: 1937-1947, 2002.
    • Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fischer RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, Lopez-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T and Staudt LM: The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. N Engl J Med 346: 1937-1947, 2002.
  • 43
    • 0043192901 scopus 로고    scopus 로고
    • A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B-cell lymphoma
    • Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A and Staudt LM: A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B-cell lymphoma. Proc Natl Acad Sci USA 19: 9991-9996, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.19 , pp. 9991-9996
    • Wright, G.1    Tan, B.2    Rosenwald, A.3    Hurt, E.H.4    Wiestner, A.5    Staudt, L.M.6
  • 44
    • 0034730186 scopus 로고    scopus 로고
    • Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large B cell lymphoma
    • Lossos IS, Alizadeh AA, Eisen MB, Chan WC, Brown PO, Botstein D, Staudt LM and Levy R: Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large B cell lymphoma. Proc Natl Acad Sci USA 97: 10290-10213, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10290-10213
    • Lossos, I.S.1    Alizadeh, A.A.2    Eisen, M.B.3    Chan, W.C.4    Brown, P.O.5    Botstein, D.6    Staudt, L.M.7    Levy, R.8
  • 45
    • 0035905313 scopus 로고    scopus 로고
    • Constitutive nuclear factor KappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
    • Davis RE, Brown KD, Siebenlist U and Staudt LM: Constitutive nuclear factor KappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 194: 1861-1874, 2001.
    • (2001) J Exp Med , vol.194 , pp. 1861-1874
    • Davis, R.E.1    Brown, K.D.2    Siebenlist, U.3    Staudt, L.M.4
  • 49
    • 1842529746 scopus 로고    scopus 로고
    • Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma
    • Chang CC, McClintock S, Cleveland RP, Trzpuc T, Vesole DH, Logan B, Kajdacsy-Balla A and Perkins SL: Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Am J Surg Pathol 28: 464-470, 2004.
    • (2004) Am J Surg Pathol , vol.28 , pp. 464-470
    • Chang, C.C.1    McClintock, S.2    Cleveland, R.P.3    Trzpuc, T.4    Vesole, D.H.5    Logan, B.6    Kajdacsy-Balla, A.7    Perkins, S.L.8
  • 51
    • 0033681015 scopus 로고    scopus 로고
    • Immunophenotypic and genotypic markers of follicular center cell neoplasia in diffuse large B-cell lymphomas
    • King BE, Chen C, Lotker J, Kant J, Okuyama K, Falini B and Swerdlow SH: Immunophenotypic and genotypic markers of follicular center cell neoplasia in diffuse large B-cell lymphomas. Mod Pathol 13: 1219-1231, 2000.
    • (2000) Mod Pathol , vol.13 , pp. 1219-1231
    • King, B.E.1    Chen, C.2    Lotker, J.3    Kant, J.4    Okuyama, K.5    Falini, B.6    Swerdlow, S.H.7
  • 52
    • 0038485626 scopus 로고    scopus 로고
    • Increased expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas
    • Bai M, Agnantis NJ, Skyrlas A, Tsanou E, Kamina S, Galani V and Kanavaros P: Increased expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas. Mod Pathol 16: 471-480, 2003.
    • (2003) Mod Pathol , vol.16 , pp. 471-480
    • Bai, M.1    Agnantis, N.J.2    Skyrlas, A.3    Tsanou, E.4    Kamina, S.5    Galani, V.6    Kanavaros, P.7
  • 53
    • 3042630871 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphomas with germinal center B-cell-like differentiation immunophenotypic profile are associated with high apoptotic index, high expression of the proapoptotic proteins bax, bak and bid and low expression of the anti-apoptotic protein bcl-xl
    • Bai M, Skyrlas A, Agnantis NJ, Tsanou E, Kamina S, Galani V and Kanavaros P: Diffuse large B-cell lymphomas with germinal center B-cell-like differentiation immunophenotypic profile are associated with high apoptotic index, high expression of the proapoptotic proteins bax, bak and bid and low expression of the anti-apoptotic protein bcl-xl. Mod Pathol 17: 847-856, 2004.
    • (2004) Mod Pathol , vol.17 , pp. 847-856
    • Bai, M.1    Skyrlas, A.2    Agnantis, N.J.3    Tsanou, E.4    Kamina, S.5    Galani, V.6    Kanavaros, P.7
  • 54
    • 6444226035 scopus 로고    scopus 로고
    • Cluster analysis of apoptosis-associated bcl2 family proteins in diffuse large B-cell lymphomas. Relations with the apoptotic index, the proliferation profile and the B-cell differentiation immunophenotypes
    • Bai M, Skyrlas A, Agnantis NJ, Kamina S, Kitsoulis P and Kanavaros P: Cluster analysis of apoptosis-associated bcl2 family proteins in diffuse large B-cell lymphomas. Relations with the apoptotic index, the proliferation profile and the B-cell differentiation immunophenotypes. Anticancer Res 24: 3081-3088, 2004.
    • (2004) Anticancer Res , vol.24 , pp. 3081-3088
    • Bai, M.1    Skyrlas, A.2    Agnantis, N.J.3    Kamina, S.4    Kitsoulis, P.5    Kanavaros, P.6
  • 55
    • 8144224903 scopus 로고    scopus 로고
    • Proliferation profile of classical Hodgkin's lymphomas. Increased expression of the protein cyclin D2 in Hodgkin and Reed-Sternberg cells
    • Bai M, Tsanou E, Agnantis NJ, Kamina S, Grepi C, Stefanaki K, Rontogianni D, Galani V and Kanavaros P: Proliferation profile of classical Hodgkin's lymphomas. Increased expression of the protein cyclin D2 in Hodgkin and Reed-Sternberg cells. Mod Pathol 17: 1338-1345, 2004.
    • (2004) Mod Pathol , vol.17 , pp. 1338-1345
    • Bai, M.1    Tsanou, E.2    Agnantis, N.J.3    Kamina, S.4    Grepi, C.5    Stefanaki, K.6    Rontogianni, D.7    Galani, V.8    Kanavaros, P.9
  • 58


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