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Volumn 34, Issue 5, 2007, Pages 460-464

The role of MD-2 in the process of endotoxin recognition and signal transduction

Author keywords

Lipopolysaccharide (LPS); Myeloid differentiation 2 (MD 2); Signal transduction; Toll like receptor 4 (TLR4)

Indexed keywords


EID: 34547725588     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (21)
  • 1
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu R, Akashi S, Ogata H, et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med, 1999, 189 (11): 1777-1782
    • (1999) J Exp Med , vol.189 , Issue.11 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3
  • 2
    • 0035834135 scopus 로고    scopus 로고
    • Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor4
    • Visintin A, Mazzoni A, Spitzer JA, et al. Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor4. Proc Natl Acad Sci USA, 2001, 98 (21): 12156-12161
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.21 , pp. 12156-12161
    • Visintin, A.1    Mazzoni, A.2    Spitzer, J.A.3
  • 3
    • 3142546368 scopus 로고    scopus 로고
    • Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition
    • Gruber A, Mancek M, Wagner H, et al. Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition. J Biol Chem, 2004, 279 (27): 28475-28482
    • (2004) J Biol Chem , vol.279 , Issue.27 , pp. 28475-28482
    • Gruber, A.1    Mancek, M.2    Wagner, H.3
  • 4
    • 0242495481 scopus 로고    scopus 로고
    • Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness
    • Re F, Strominger J L. Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J Immunol, 2003, 171 (10): 5272-5276
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 5272-5276
    • Re, F.1    Strominger, J.L.2
  • 5
    • 33744966026 scopus 로고    scopus 로고
    • Mutational analysis of membrane and soluble forms of human MD-2
    • Viriyakosol S, Tobias P S, Kirkland T N, et al. Mutational analysis of membrane and soluble forms of human MD-2. J Biol Chem, 2006, 281 (17): 11955-11964
    • (2006) J Biol Chem , vol.281 , Issue.17 , pp. 11955-11964
    • Viriyakosol, S.1    Tobias, P.S.2    Kirkland, T.N.3
  • 6
    • 0037388127 scopus 로고    scopus 로고
    • The role of disulfide bonds in the assembly and function of MD-2
    • Mullen G E, Kennedy M N, Visintin A, et al. The role of disulfide bonds in the assembly and function of MD-2. Proc Natl Acad Sci USA, 2003, 100 (7): 3919-3924
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.7 , pp. 3919-3924
    • Mullen, G.E.1    Kennedy, M.N.2    Visintin, A.3
  • 7
    • 0346850824 scopus 로고    scopus 로고
    • Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction
    • Visintin A, Latz E, Monks BG, et al. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J Biol Chem, 2003, 278 (48): 48313-48320
    • (2003) J Biol Chem , vol.278 , Issue.48 , pp. 48313-48320
    • Visintin, A.1    Latz, E.2    Monks, B.G.3
  • 8
    • 27644578690 scopus 로고    scopus 로고
    • Conserved mechanisms of signal transduction by Toll and Toll-like receptors
    • Gangloff M, Weber AN, Gay NJ. Conserved mechanisms of signal transduction by Toll and Toll-like receptors. J Endotoxin Res, 2005, 11 (5): 294-298
    • (2005) J Endotoxin Res , vol.11 , Issue.5 , pp. 294-298
    • Gangloff, M.1    Weber, A.N.2    Gay, N.J.3
  • 9
    • 33646494167 scopus 로고    scopus 로고
    • Regulatory roles for MD-2 and TLR4 in ligand- induced receptor clustering
    • Kobayashi M, Saitoh S, Tanimura N, et al. Regulatory roles for MD-2 and TLR4 in ligand- induced receptor clustering. J Immunol, 2006, 176(10):6211-6218
    • (2006) J Immunol , vol.176 , Issue.10 , pp. 6211-6218
    • Kobayashi, M.1    Saitoh, S.2    Tanimura, N.3
  • 10
    • 0036301797 scopus 로고    scopus 로고
    • Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    • Nagai Y, Akashi S, Nagafuku M, et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol, 2002, 3 (7): 667-672
    • (2002) Nat Immunol , vol.3 , Issue.7 , pp. 667-672
    • Nagai, Y.1    Akashi, S.2    Nagafuku, M.3
  • 12
    • 0037619127 scopus 로고    scopus 로고
    • MD-2 is necessary for the toll-like receptor 4 protein to undergo glycosylationessential for its translocation to the cell surface
    • Ohnishi T, Muroi M, Tanamoto K. MD-2 is necessary for the toll-like receptor 4 protein to undergo glycosylationessential for its translocation to the cell surface. Clin Diagn Lab Immunol, 2003, 10 (3): 405-410
    • (2003) Clin Diagn Lab Immunol , vol.10 , Issue.3 , pp. 405-410
    • Ohnishi, T.1    Muroi, M.2    Tanamoto, K.3
  • 13
    • 9144271703 scopus 로고    scopus 로고
    • Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling
    • Hyakushima N, Mitsuzawa H, Nishitani C. Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling. J Immunol, 2004, 173 (11): 6949-6954
    • (2004) J Immunol , vol.173 , Issue.11 , pp. 6949-6954
    • Hyakushima, N.1    Mitsuzawa, H.2    Nishitani, C.3
  • 14
    • 33751584426 scopus 로고    scopus 로고
    • Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice
    • Mitsuzawa H, Nishitani C, Hyakushima N, et al. Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice. J Immunol, 2006, 177 (11): 8133-8139
    • (2006) J Immunol , vol.177 , Issue.11 , pp. 8133-8139
    • Mitsuzawa, H.1    Nishitani, C.2    Hyakushima, N.3
  • 15
    • 8344251963 scopus 로고    scopus 로고
    • Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling
    • Saitoh S, Akashi S, Yamada T, et al. Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling. J Endotoxin Res, 2004, 10 (4): 257-260
    • (2004) J Endotoxin Res , vol.10 , Issue.4 , pp. 257-260
    • Saitoh, S.1    Akashi, S.2    Yamada, T.3
  • 16
    • 3242690772 scopus 로고    scopus 로고
    • Lipid A antagonist, lipid IV a, is distinct from lipid A in interaction with Toll-like receptor 4(TLR4) -MD-2 and ligand-induced TLR4 oligomerization
    • Saitoh S, Akashi S, Yamada T, et al. Lipid A antagonist, lipid IV a, is distinct from lipid A in interaction with Toll-like receptor 4(TLR4) -MD-2 and ligand-induced TLR4 oligomerization. Int Immunol, 2004, 16 (7): 961-969
    • (2004) Int Immunol , vol.16 , Issue.7 , pp. 961-969
    • Saitoh, S.1    Akashi, S.2    Yamada, T.3
  • 17
    • 33745305542 scopus 로고    scopus 로고
    • Analysis of TLR4 polymorphic variants: New insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling
    • Rallabhandi P, Bell J, Boukhvalova MS, et al. Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol, 2006, 177(1): 322-332
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 322-332
    • Rallabhandi, P.1    Bell, J.2    Boukhvalova, M.S.3
  • 18
    • 10244229656 scopus 로고    scopus 로고
    • Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
    • Pugin J, Stem-Voeffray S, Daubeuf B, et al. Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood, 2004, 104 (13):4071-4079
    • (2004) Blood , vol.104 , Issue.13 , pp. 4071-4079
    • Pugin, J.1    Stem-Voeffray, S.2    Daubeuf, B.3
  • 19
    • 3242708716 scopus 로고    scopus 로고
    • Endotoxin responsiveness ofhuman airway epithelia is limited by low expression of MD-2.Am
    • Jia HP, Kline JN, Penisten A, et al. Endotoxin responsiveness ofhuman airway epithelia is limited by low expression of MD-2.Am J Physiol, 2004, 287 (2):L428-437
    • (2004) J Physiol , vol.287 , Issue.2
    • Jia, H.P.1    Kline, J.N.2    Penisten, A.3
  • 20
    • 4544254589 scopus 로고    scopus 로고
    • Identification of a novel isoform of MD-2 that downregulates lipopolysaccharide signaling.Biochem
    • Ohta S, Bahrun U, Tanaka M, et al. Identification of a novel isoform of MD-2 that downregulates lipopolysaccharide signaling.Biochem Biophys Res Commun, 2004, 323 (3): 1103-1108
    • (2004) Biophys Res Commun , vol.323 , Issue.3 , pp. 1103-1108
    • Ohta, S.1    Bahrun, U.2    Tanaka, M.3
  • 21
    • 28444490358 scopus 로고    scopus 로고
    • Divanovic S, Trompette A, Atabani SF, et al. Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.J Endotoxin Res, 2005, 11 (6): 363-368
    • Divanovic S, Trompette A, Atabani SF, et al. Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.J Endotoxin Res, 2005, 11 (6): 363-368


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.