Ethanol-related gastric mucosal damage: Evidence of a free radical-mediated mechanism and beneficial effect of oral supplementation with Bionormalizer, a novel natural antioxidant

Digestion

Volumn 60, Issue 6, 1999, Pages 538-543

  Marotta, F ^a,d   Tajiri, H ^b   Safran, P ^c   Fesce, E ^a   Ideo, G ^a  

^a S Giuseppe Hospital   (Italy)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^c SFJO and Laboratories   (France)

^d NONE   (Italy)

Author keywords

Antioxidant; Bionormalizer; Ethanol induced gastric mucosal damage; Free radicals

Indexed keywords

ALCOHOL; ANTIOXIDANT; FREE RADICAL; GLUTATHIONE; MALONALDEHYDE; XANTHINE OXIDASE;

ARTICLE; CHEMOLUMINESCENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; GASTROSCOPY; HISTOLOGY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH MUCOSA INJURY;

ADMINISTRATION, ORAL; ADULT; ANTIOXIDANTS; BIOPSY; DOUBLE-BLIND METHOD; ETHANOL; FEMALE; FREE RADICAL SCAVENGERS; GASTRIC MUCOSA; GASTROSCOPY; HEALTH FOOD; HUMANS; MALE; MALONDIALDEHYDE; REFERENCE VALUES; STOMACH DISEASES; XANTHINE OXIDASE;

EID: 0032700409     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007703     Document Type: Article

References (33)

1. Zselenyi I, Brune K: Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 1988;33:865-871.
2. Ligumsky M, Sestieri M, Okon E, Ginsburg I: Antioxidants inhibit ethanol-induced gastric injury in the rat. Scand J Gastroenterol 1995; 30:854-860.
3. Mutoh H, Hiraishi H, Ota S, Yoshida H, Ivey KJ, Terano A, Sugimoto T: Protective role of intracellular glutathione against ethanol-induced damage in cultured rat gastric mucosal cells. Gastroenterology 1990;98:1452-1459.
4. Loguercio C, Romano M, Di Sapio M, Nardi G, Taranto D, Grella A: Regional variations in total and nonprotein sulfhydryl compounds in the human gastric mucosa and effects of ethanol. Scand J Gastroenterol 1991;26:1042-1048.
5. Loguercio C, Taranto D, Beneduce F, del Vecchio Blanco C, de Vincentiis A, Nardi G, Romano M: Glutathione prevents ethanol induced gastric mucosal damage and depiction of sulphydryl compounds in humans. Gut 1993; 34:161-165.
6. Baraona E, Julkunen R, Tannenhaum L, Lieber CS: The role of intestinal bacteria over-growth in ethanol production and metabolism in rats. Gastroenterology 1986;90:103-110.
7. Smith GS, Mercer DW, Cross JM, Barrcto JC, Miller TA: Gastric injury induced by ethanol and ischemia-reperfusion in the rat. Differing roles for lipid peroxidation and oxygen radicals. Dig Dis Sci 1996;41:1157-1164.
8. Smith GS, Barreto JC, Schmidt KL, Tornwall MS, Miller TA: Protective effect of dimethylthiourea against mucosal injury in rat stomach. Implications for hydroxyl radical mechanism. Dig Dis Sci 1992;37:1345-1355.
9. Marotta F, Reizakovic I, Safran P, Ideo G: Abstinence-induced oxidative stress in moderate drinkers is improved by Bionormalizer. Hepatogastroenterology 1997;44:1360-1366.
10. Lanza FL, Roger GL, Nelson RS: Endoscopic evaluation of the effects of aspirin, buffered aspirin and enteric-coated aspirin on gastric and duodenal mucosa. N Engl J Med 1980;303: 136-138.
11. Davies GR, Simmonds NJ, Stevens TRJ, Grandison A, Blake DR, Rampton DS: Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut 1992;33:1467-1472.
12. Prajda N, Weber G: Malignant transformation linked imbalance decreased XO activity in hepatomas. FEBS Lett 1975;59:245-249.
13. Newton GL, Dorian R, Fahey RC: Analysis of biological thiols: Derivatization with monobromobimane and separation by reverse phase high pressure liquid chromatography. Anal Biochem 1981;114:383-387.
14. Peng YM, Peng YS, Lin Y: A nonsaponification method for the determination of carotenoids, retinoids and tocopherols in solid human tissue. Cancer Epidemiol Biomarkers Prev 1993;2:139-144.
15. Yagi K: Lipid peroxide and human diseases. Chem Phys Lipids 1987;45:337-351.
16. Guèmori L, Artur Y, Herbeth B, et al: Biological variability of superoxide dismutase, glutathione peroxidase and catalase in human blood. Clin Chem 1991;37:1932-1937.
17. Ohishi N, Ohkawa H, Miike A, et al: A new assay method for lipid peroxides using a methylene blue derivative. Biochem Int 1985;10: 205-211.
18. Burton GW, Webb A, Ingold KU: A mild, rapid and efficient method of lipid extraction for use in determining vitamin E lipid ratios. Lipids 1985;20:29-39.
19. Santiago LA, Osato JA, Hiramatsu M, et al: Free radical scavenging action of Bio-catalizer and its bioproducts. Free Radie Biol Med 1991; 11:379-383.
20. Haramaki N, Marcocci L, D'Anna R, et al: Biocatalizer-alpha.rho No. 11 (Bio-Normalizer) supplementation: Effect on oxidative stress to isolated rat hearts. Biochem Mol Biol Int 1995; 36:1263-1268.
21. Korkina L, Osato JA, Chivilyeva I, et al: Radio-protective and antioxidant effect of zinc aspartate and Bionormalizer in children with acute myelo-and lympholeukemias. Nutrition 1995; 11:555-558.
22. Marcocci L, D'Anna R, Yan LJ, Haramaki N, Packer L: Efficacy of Bionormalizer supplementation against peroxyl radical-induced oxidative damage in rat organ homogenates. Biochem Mol Biol Int 1996;38:535-541.
23. Shaw S, Herbert C, Colman N, Jayatilleke E: Effect of ethanol-generated free radicals on gastric intrinsic factor and glutathione. Alcohol 1990;7:153-157.
24. Osato JA, Afanas'ev IB, Korkina LG, Santiago LA, Horitsu H, Mori A: Bionormalizer modulates free radicals in brain, blood and macrophage. Free Radic Biol Med 1994;2:G/G9.
25. Osato JA, Korkina LG, Santiago LA, Afanas'ev IB: Effects of Bionormalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes and rat peritoneal macrophages. Nutrition 1995;11: 568-572.
26. Dinda PK, Kossev P, Beck IT, Buell NG: Role of xanthine oxidase-derived oxidants and leukocytes in ethanol-induced jejunal mucosal injury. Dig Dis Sci 1996;41:2461-2470.
27. Osato JA, Afanas'ev IB, Zianida P, Cheremisina TB, Suslova NE, Abramova EV, Mikhalchik IB, Deeva IB, Santiago LA, Korkina LG: Bionormalizer as a modulator of phagocytes and a free radical production by murine inflamed neutrophils and macrophages. Phys Chem Biol Med 1995;2:87-95.
28. Shinohara M, Morikawa Y, Ogata K, Osato JA, Ohura K: Effect of Bionormalizer on macrophage chemotaxis in naturally-occurring gingivitis in rat. Can J Physiol Pharmacol 1994:72: A87.
29. Olson CE: Glutathionc modulates toxic oxygen metabolite injury of canine chief cell monolayers in primary culture. Am J Physiol 1988; 254:G49-G56.
30. Hirokawa M, Miura S, Yoshida H, Kurose I, Hokari R, Takeuchi T, Higuchi H, Watanabe N, Zeki S: Oxidative stress and mitochondrial damage precedes gastric cell death exposed to ethanol. Digestive Disease Week, May 1997, Washington.
31. Deneke SM, Fanburg BL: Regulation for cellular glutathione. Am J Physiol 1989;257:L163-L173.
32. Salim AS: Sulfydryls protect patients against complications of erosive gastritis. Dig Dis Sci 1990;35:1436-1438.
33. Sanderson JS, White KLM, Drake IM, Schorah CJ: Vitamin E and carotenoids in gastric biopsies: The relation to plasma concentrations in patients with and without Helicobacter pylori gastritis. Am J Clin Nutr 1997;65:101-106.