Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers

Gut

Volumn 38, Issue 4, 1996, Pages 518-524

  McAlindon, M E ^a,b   Muller, A F ^a   Filipowicz, B ^a   Hawkey, C J ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Allopurinol; Aspirin; Gastroduodenal injury; Sulphasalazine; Vitamin C

Indexed keywords

ACETYLSALICYLIC ACID; ALLOPURINOL; ANTIOXIDANT; ASCORBIC ACID; PLACEBO; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; SALAZOSULFAPYRIDINE; THROMBOXANE B2;

ADULT; ARTICLE; CHEMOLUMINESCENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ENDOSCOPY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; STOMACH INJURY; STOMACH MUCOSA; STOMACH PROTECTION; VOLUNTEER;

EID: 0029998774     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.38.4.518     Document Type: Article

References (56)

1. Graham DY, Lacey Smith J, Spjut HJ, Torres E. Gastric adaptation: studies in humans during continuous aspirin administration. Gastroenterology 1988; 95: 327-33.
2. Hawkey CJ. Review article: aspirin and gastrointestinal bleeding. Aliment Pharmacol Ther 1994; 8: 141-6.
3. Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990; 259: G462-7.
4. Vaananen PM, Meddings JB, Wallace JL. Role of oxygen-derived free radicals in indomethacin-induced gastric injury. Am J Physiol 1991; 261: G470-5.
5. Itoh M, Guth PH. Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 1985; 88: 1162-7.
6. Perry MA, Wadhwa S, Parks DA, Pickard W, Granger DN. Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterology 1986; 90: 362-7.
7. Salim AS. Gastric mucosal cytoprotection in the rat by scavenging oxygen-derived free radicals. Am J Med Sci 1991; 302: 287-91.
8. Ashley SW, Sonnenschein LA, Cheung LY. Focal gastric mucosal blood flow at the site of aspirin-induced ulceration. Am J Surg 1985; 149: 53-9.
9. Gana TJ, Huholewych R, Koo J. Focal gastric mucosal blood flow in aspirin-induced ulceration. Ann Surg 1987; 205: 399-403.
10. Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol-or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987; 32: 1395-401.
11. Rachmilewitz D, Karmeli F, Okon E, Samuni A. A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats. Gut 1994; 35: 1181-8.
12. Yoshikawa T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, et al. Role of active oxygen, lipid peroxidation and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut 1993; 34: 732-7.
13. Salim AS. A new approach to the treatment of non-steroidal anti-inflammatory drugs induced gastric bleeding by free radical scavengers. Surg Gynecol Obstet 1992; 175: 484-90.
14. Lanza FL, Roger GL, Nelson RS. Endoscopic evaluation of the effects of aspirin, buffered aspirin and enteric-coated aspirin on gastric and duodenal mucosa. N Engl J Med 1980; 303: 136-8.
15. Hawkey CJ, Hawthorne AB, Hudson N, Cole AT, Mahida YR, Daneshmend TK. Separation of the impairment of haemostasis by aspirin from mucosal injury in the human stomach. Clin Sci 1991; 81: 565-73.
16. DeChatelet LR, Long GD, Shirley PS, Bass DA, Thomas MJ, Henderson FW, et al. Mechanism of the luminol-dependent chemiluminescence of human neutrophils. J Immunol 1982; 129: 1589-93.
17. Christiansen NO. A time-course study on superoxide generation and protein kinase C activation in human neutrophils. FEBS Lett 1988; 239: 195-8.
18. Zeller JM, Sullivan BL. C-reactive protein selectively enhances the intracellular generation of reactive oxygen products by IgG-stimulated monocytes and neutrophils. J Leuk Biol 1992; 52: 449-55.
19. Kitahora T, Guth PH. Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation. Gastroenterology 1987; 93: 810-7.
20. Sallie RW, Swanson NR, Reed WD. Allopurinol protects rat gastric mucosa against acute indomethacin-induced erosions and ulceration. Aust NZ J Med 1987; 17 (suppl): 495.
21. 2 metabolism. Gut 1992; 33: 164-9.
22. Konturek SJ, Kwiecien N, Obtulowitz W, Kiec-Dembinska A, Polanski M, Kopp B, et al. Effect of carprofen and indomethacin on gastric function, mucosal integrity and generation of prostaglandins in men. Hepatogastroenterology 1982; 29: 267-70.
23. Ezer E, Pálosi E, Hajós G, Szporny L. Comparative pharmacology of a 1:10 combination of indomethacin-sodium salicylate. Agents Actions 1979; 9: 117-23.
24. Hayden LJ, Thomas G, West GB. Inhibitors of gastric lesions in the rat. J Pharm Pharmacol 1978; 30: 244-6.
25. Torgyán S, Ady E, Wagner L, Neumann T, Béres G, Csányi M. Reduction of indomethacin-induced gastrointestinal blood loss by sodium salicylate in man. Int J Clin Pharmacol Biopharm 1978; 16: 610-1.
26. Berry CN, Prouteau M, Lloyd KG. Sulphasalazine and PhCL28A inhibit the formation of ethanol-and phenylbutazone-induced rat gastric ulcers: lack of involement of endogenous prostaglandins? Br J Pharmacol 1988; 93: 465-72.
27. Cho CH, Ogle CW, Sevilla EL. The protective effects of sulphasalazine against ethanol-induced gastric damage in rats. Br J Pharmacol 1987; 92: 31-7.
28. Del Soldato P, Foschi D, Varin L, Daniotti S. Indomethacin-induced intestinal ulcers in rats: effects of salicylazosulfapyridine and dexamethasone. Agents Actions 1985; 16: 393-6.
29. Ligumski M, Hansen DG, Kauffman GL. Salicylic acid blocks indomethacin-and aspirin-induced cyclo-oxygenase inhibition in rat gastric mucosa. Gastroenterology 1982; 83: 1043-6.
30. Yesair DW, Callahan M, Remington L, Kensler CJ. Comparative effects of salicylic acid, phenylbutazone, probenecid, and other anions on the metabolism, distribution, and excretion of indomethacin by rats. Biochem Pharmacol 1970; 19: 1591-600.
31. Ahnfelt-Ronne I, Nielsen OH, Christensen A, Langholz E, Binder V, Riis P. Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid. Gastroenterology 1990; 98: 1162-9.
32. Von Ritter C, Grisham MB, Granger DN. Sulfasalazine metabolites and dapsone attenuate formyl-methionylleucyl-phenylalanine-induced mucosal injury in rat ileum. Gastroenterology 1989; 96: 811-6.
33. Neal TM, Winterbourn Cc, Vissers MCM. Inhibition of neutrophil degranulation and superoxide production by sulfasalazine: comparison with 5-aminosalicylic acid, sulphapyridine and olsalazine. Biochem Pharmacol 1987; 36: 2765-8.
34. Allgayer H, Rang S, Klotz U, Böhne P, Retey J, Kruis W, et al. Superoxide inhibition following different stimuli of respiratory burst and metabolism of aminosalicylates in neutrophils. Dig Dis Sci 1994; 39: 145-51.
35. Nielson OH, Bouchelouche PN, Berild D, Ahnfelt-Rønne I. Effect of 5-aminosalicylic acid and analagous substances on superoxide generation and intracellular free calcium in human neutrophilic granulocytes. Scand J Gastroenterol 1993; 28: 527-32.
36. Gionchetti P, Guarnieri C, Campieri M, Belluzzi A, Brignola C, Iannone P, et al. Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation. Dig Dis Sci 1991; 36: 174-8.
37. Williams G. Phagocytes, toxic oxygen metabolites and inflammatory bowel disease: implications for treatment. Ann R Coll Surg Engl 1990; 72: 253-62.
38. Cohen MM, Duncan AM. Ascorbic acid nutrition in gastroduodenal disorders. BMJ 1967; 4: 516-8.
39. Russell RJ, Williamson JM, Goldberg A, Wares H. Ascorbic acid levels in leucocytes of patients with gastrointestinal haemorrhage. Lancet 1968; 2: 603-6.
40. Russell RI, Goldberg A. Effect of aspirin on the gastric mucosa of guineapigs on a scorbutogenic diet. Lancet 1968; ii: 606-8.
41. Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971; i: 937-8.
42. Basu TK. Influence of drugs on bioavailability of vitamin C. In: Counsell JN, Hornig DH, eds. Vitamin C. London: Applied Science, 1981: 275-81.
43. Niki E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Am J Clin Nutr 1991; 54: 1119-24S.
44. Rathbone BJ, Johnson AW, Wyatt JI, Kelleher J, Heatley RV, Losowsky MS. Ascorbic acid: a factor concentrated in human gastric juice. Clin Sci 1989; 76: 237-41.
45. Loh HS, Wilson CWM. The effects of aspirin on the metabolic availability of ascorbic acid in human beings. J Cell Pharmacol 1973; 13: 480-6.
46. Loh HS, Wilson CWM. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975; 15: 36-45.
47. Waring A, Drake IM, Schorah C, Axon ATR, White K. Ascorbic acid concentrations in plasma, gastric juice and gastrointestinal mucosa. Effects of gastritis and oral supplementation. Gut 1994; 35 (suppl 2): S19.
48. Taylor TV, Rimmer S, Day B, Butcher J, Dymock IW. Ascorbic acid supplementation in the treatment of pressure sores. Lancet 1974; ii: 544-6.
49. Stevenson NR. Active transport of L-ascorbic acid in the human ileum. Gastroenterology 1974; 67: 952-6.
50. Mellors AJ, Nahrwold DL, Rose RC. Ascorbic acid flux across mucosal border of guinea pig and human ileum. Am J Physiol 1977; 233: E374-9.
51. Arvanitakis C, Chen G-H, Folscroft J, Greenberger NJ. Effect of aspirin on intestinal absorption of glucose, sodium, and water in man. Gut 1977; 18: 187-90.
52. Bianchi J, Wilson FA, Rose RC. Dehydroascorbic acid and ascorbic acid transort systems in the guinea pig ileum. Am J Physiol 1986; 250: G461-8.
53. Rose RC, Choi J-L, Koch MJ. Intestinal transport and metabolism of oxidised ascorbic acid (dehydroascorbic acid). Am J Physiol 1988; 254: G824-8.
54. Padh H. Vitamin C: newer insights into its biochemical functions. Nutr Rev 1991; 49: 65-9.
55. Crandon JH, Lund CC, Dill DB. Experimental human scurvy. N Engl J Med 1940; 223: 353.
56. Afifi AM, Ellis L, Huntsman RG, Said MI. High dose ascorbic acid in the management of thalassaemia leg ulcers - a pilot study. Br J Dermatol 1975; 92: 339-41.