Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 19, 2007, Pages 6425-6442

  Kaila, Neelu ^a   Green, Neal ^a   Li, Huan Qiu ^a   Hu, Yonghan ^a   Janz, Kristin ^a   Gavrin, Lori Krim ^a   Thomason, Jennifer ^a   Tam, Steve ^a   Powell, Dennis ^b   Cuozzo, John ^c   Hall, J Perry ^a   Telliez, Jean Baptiste ^a   Hsu, Sang ^a   Nickerson Nutter, Cheryl ^a   Wang, Qin ^a   Lin, Lih Ling ^a  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

^c Praecis Pharmaceuticals   (United States)

Author keywords

1,7 Naphthyridine 3 carbonitriles; Quinoline 3 carbonitriles; Tpl2 kinase

Indexed keywords

4 CYCLOHEPTYLAMINO 7 [(PYRIDIN 3 YLMETHYL)AMINO][1,7]NAPHTHYRIDINE 3 CARBONITRILE; CYANIDE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR PROGRESSION LOCI 2 KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; MALE; MICHAEL ADDITION; MONOCYTE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REACTION ANALYSIS; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BINDING, COMPETITIVE; CYCLOHEPTANES; ENZYME INHIBITORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NAPHTHYRIDINES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 34547666801     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.054     Document Type: Article

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