Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2893-2897

  Wissner, Allan ^a   Brawner Floyd, M ^a   Rabindran, Sridhar K ^a   Nilakantan, Ramaswamy ^a   Greenberger, Lee M ^a   Shen, Ru ^a   Wang, Yu Fen ^a   Tsou, Hwei Ru ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CL 1033; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERLOTINIB; GEFITINIB; PELITINIB; PHOSPHOTRANSFERASE INHIBITOR; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; CELL LINE; CYCLIZATION; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRILES; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 0037152415     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00598-X     Document Type: Article

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