Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-β-cyclodextrin in infants, children, and adolescents

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 8, 2007, Pages 2668-2673

  Abdel Rahman, Susan M ^a,b   Jacobs, Richard F ^c   Massarella, Joseph ^d   Kauffman, Ralph E ^a,b   Bradley, John S ^e   Kimko, Hui C ^d   Kearns, Gregory L ^a,b   Shalayda, Kevin ^d   Curtin, Christopher ^d   Maldonado, Samuel D ^d   Blumer, Jeffrey L ^f,g  

^a CHILDREN S MERCY HOSPITAL   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^c ARKANSAS CHILDREN S HOSPITAL   (United States)

^d JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^e RADY CHILDREN'S HOSPITAL   (United States)

^f CASE WESTERN RESERVE UNIVERSITY   (United States)

^g CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CYTOCHROME P450 3A4; HYDROXYITRACONAZOLE; ITRACONAZOLE;

ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; DISTRIBUTION VOLUME; DOSE RESPONSE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; INJECTION SITE STINGING; MALE; MULTICENTER STUDY; MYCOSIS; PLASMA CLEARANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE DRUG DOSE; STATISTICAL ANALYSIS;

ADOLESCENT; ANTIFUNGAL AGENTS; BETA-CYCLODEXTRINS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INJECTIONS, INTRAVENOUS; ITRACONAZOLE; MALE; MYCOSES;

EID: 34547635098     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00297-07     Document Type: Article

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