Intrapulmonary pharmacokinetics and pharmacodynamics of itraconazole and 14-hydroxyitraconazole at steady state

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 10, 2004, Pages 3823-3827

  Conte Jr , John E ^a,b   Golden, Jeffrey A ^a   Kipps, Juliana ^a   McIver, Marina ^a   Zurlinden, Elisabeth ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYITRACONAZOLE; ITRACONAZOLE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; BRONCHOSCOPY; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; EPITHELIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG LAVAGE; METABOLITE; MYCOSIS; NORMAL HUMAN; PLASMA HALF LIFE; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; STEADY STATE;

ADULT; ANTIFUNGAL AGENTS; AREA UNDER CURVE; BIOTRANSFORMATION; BRONCHOALVEOLAR LAVAGE FLUID; EPITHELIUM; FEMALE; HALF-LIFE; HUMANS; ITRACONAZOLE; LUNG; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PULMONARY ALVEOLI; SPECIMEN HANDLING;

EID: 4644274436     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.10.3823-3827.2004     Document Type: Article

References (44)

1. Andes, D., K. Marchillo, R. Conklin, G. Krishna, F. Ezzet, A. Cacciapuoti, and D. Loebenberg. 2004. Pharmacodynamics of a new triazole, posaconazole, in a murine model of disseminated candidiasis. Antimicrob. Agents Chemother. 48:137-142.
2. Andes, D., K. Marchillo, T. Stamstad, and R. Conklin. 2003. In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model. Antimicrob. Agents Chemother. 47:1193-1199.
3. Andes, D., K. Marchillo, T. Stamstad, and R. Conklin. 2003. In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model. Antimicrob. Agents Chemother. 47:3165-3169.
4. Andes, D., and M. van Ogtrop. 1999. Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection model. Antimicrob. Agents Chemother. 43:2116-2120.
5. Anonymous. 2000. Dietary guidelines for Americans, 2000, p. 1-44. U.S. Department of Agriculture, Washington, D.C. [Online.] http://www.health.gov/ dietaryguidelines/.
6. Baldwin, D. R., R. Wise, J. M. Andrews, J. P. Ashby, and D. Honeybourne. 1990. Azithromycin concentrations at the sites of pulmonary infection. Eur. Respir. J. 3:886-890.
7. Barbaro, G., G. Barbarini, W. Calderon, B. Grisorio, P. Alcini, and G. Di Lorenzo. 1996. Fluconazole versus itraconazole for candida esophagitis in acquired immunodeficiency syndrome. Candida Esophagitis. Gastroenterology 111:1169-1177.
8. Barone, J. A., J. G. Koh, R. H. Bierman, J. L. Colaizzi, K. A. Swanson, M. C. Gaffar, B. L. Moskovitz, W. Mechlinski, and D. V. Van. 1993. Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers. Antimicrob. Agents Chemother. 37:778-784.
9. Bow, E. J., M. Laverdiere, N. Lussier, C. Rotstein, M. S. Cheang, and S. Ioannou. 2002. Antifungal prophylaxis for severely neutropenic chemotherapy recipients: a meta analysis of randomized-controlled clinical trials. Cancer 94:3230-3246.
10. Bradsher, R. W., S. W. Chapman, and P. G. Pappas. 2003. Blastomycosis. Infect. Dis. Clin. N. Am. 17:21-40.
11. Burgess, D. S., and R. W. Hastings. 2000. A comparison of dynamic characteristics of fluconazole, itraconazole, and amphotericin B against Cryptococcus neoformans using time-kill methodology. Diagn. Microbiol. Infect. Dis. 38:87-93.
12. Burgess, D. S., R. W. Hastings, K. K. Summers, T. C. Hardin, and M. G. Rinaldi. 2000. Pharmacodynamics of fluconazole, itraconazole, and amphotericin B against Candida albicans. Diagn. Microbiol. Infect. Dis. 36:13-18.
13. Caillot, D. 2003. Intravenous itraconazole followed by oral itraconazole for the treatment of amphotericin-B-refractory invasive pulmonary aspergillosis. Acta Haematol. 109:111-118.
14. Compas, D., D. J. Touw, and P. N. de Goede. 1996. Rapid method for the analysis of itraconazole and hydroxyitraconazole in serum by high-performance liquid chromatography. J. Chromatogr. B Biomed. Appl. 687:453-456.
15. Conte, J. E., Jr., J. Golden, S. Duncan, E. McKenna, E. Lin, and E. Zurlinden. 1996. Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects. Antimicrob. Agents Chemother. 40:1617-1622.
16. Conte, J. E., Jr., J. A. Golden, J. Kipps, E. T. Lin, and E. Zurlinden. 2001. Effects of AIDS and gender on steady-state plasma and intrapulmonary ethambutol concentrations. Antimicrob. Agents Chemother. 45:2891-2896.
17. Conte, J. E., Jr., J. A. Golden, J. Kipps, and E. Zurlinden. 2002. Intrapulmonary pharmacokinetics of linezolid. Antimicrob. Agents Chemother. 46: 1475-1480.
18. Conte, J. E., Jr., J. A. Golden, M. McQuitty, J. Kipps, S. Duncan, E. McKenna, and E. Zurlinden. 2002. Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid. Antimicrob. Agents Chemother. 46:2358-2364.
19. Conte, J. E., Jr., J. A. Golden, M. McQuitty, J. Kipps, E. T. Lin, and E. Zurlinden. 2000. Single-dose intrapulmonary pharmacokinetics of rifapentine in normal subjects, Antimicrob. Agents Chemother. 44:985-990.
20. Gonzalez, G. M., R. Tijerina, L. K. Najvar, R. Bocanegra, M. Rinaldi, D. Loebenberg, and J. R. Graybill. 2002. In vitro and in vivo activities of posaconazole against Coccidioides immitis. Antimicrob. Agents Chemother. 46:1352-1356.
21. Hardin, T. C., J. R. Graybill, R. Fetchick, R. Woestenborghs, M. G. Rinaldi, and J. G. Kuhn. 1988. Pharmacokinetics of itraconazole following oral administration to normal volunteers. Antimicrob. Agents Chemother. 32:1310-1313.
22. Heykants, J., A. Van Peer, V. Van de Velde, P. Van Rooy, W. Meuldermans, K. Lavrijsen, R. Woestenborghs, J. Van Cutsem, and G. Cauwenbergh. 1989. The clinical pharmacokinetics of itraconazole: an overview. Mycoses 32(Suppl. 1):67-87.
23. Hostetler, J. S., J. Heykants, K. V. Clemons, R. Woestenborghs, L. H. Hanson, and D. A. Stevens. 1993. Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient variations in concentrations. Antimicrob. Agents Chemother. 37:2224-2227.
24. Humphrey, M. J., S. Jevons, and M. H. Tarbit. 1985. Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans. Antimicrob. Agents Chemother. 28:648-653.
25. Kauffman, C. A. 1996. Role of azoles in antifungal therapy. Clin. Infect. Dis. 22(Suppl. 2):S148-S153.
26. MacGowan, A. P. 2003. Pharmacokinetic and pharmacodynamic profile of linezolid in healthy volunteers and patients with gram-positive infections. J. Antimicrob. Chemother. 51(Suppl. 2):ii17-ii25.
27. Manavathu, E. K., J. L. Cutright, and P. H. Chandrasekar. 1998. Organism-dependent fungicidal activities of azoles. Antimicrob. Agents Chemother. 42:3018-3021.
28. Odds, F. C., and H. V. Bossche. 2000. Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro. J. Antimicrob. Chemother. 45:371-373.
29. Perfect, J. R., D. V. Savani, and D. T. Durack. 1993. Uptake of itraconazole by alveolar macrophages. Antimicrob. Agents Chemother. 37:903-904.
30. Pfaller, M. A., D. J. Diekema, S. A. Messer, R. J. Hollis, and R. N. Jones. 2003. In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolates. Antimicrob. Agents Chemother. 47:1068-1071.
31. Pfaller, M. A., S. A. Messer, R. J. Hollis, R. N. Jones, and the Sentry Participants Group. 2002. Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program, 2000. Antimicrob. Agents Chemother. 46:1032-1037.
32. Picardi, M., A. Camera, L. Luciano, R. Ciancia, and B. Rotoli. 2003. Intravenous itraconazole for treating invasive pulmonary aspergillosis in neutropenic patients with acute lymphoblastic leukemia. Haematologica 88:ELT01.
33. Poirier, J. M., and G. Cheymol. 1998. Optimisation of itraconazole therapy using target drug concentrations. Clin. Pharmacokinet. 35:461-473.
34. Rennard, S. I., G. Basset, D. Lecossier, K. M. O'Donnell, P. Pinkston, P. G. Martin, and R. G. Crystal. 1986. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J. Appl. Physiol. 60:532-538.
35. Saag, M. S., G. A. Cloud, J. R. Graybill, J. D. Sobel, C. U. Tuazon, P. C. Johnson, W. J. Fessel, B. L. Moskovitz, B. Wiesinger, D. Cosmatos, L. Riser, C. Thomas, R. Hafner, W. E. Dismukes, et al. 1999. A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. Clin. Infect. Dis. 28:291-296.
36. Schafer-Korting, M., H. C. Korting, F. Amann, R. Peuser, and A. Lukacs. 1991. Influence of albumin on itraconazole and ketoconazole antifungal activity: results of a dynamic in vitro study. Antimicrob. Agents Chemother. 35:2053-2056.
37. Schafer-Korting, M., H. C. Korting, W. Rittler, and W. Obermuller. 1995. Influence of serum protein binding on the in vitro activity of anti-fungal agents. Infection 23:292-297.
38. Talke, H., and G. E. Schubert. 1965. Enzymatische harnstoffbestimmung im blut und serum im optischem test nach warburg. Klin. Wochenschr. 43:174.
39. Terrell, C. L. 1999. Antifungal agents. Part II. The azoles. Mayo Clin. Proc. 74:78-100.
40. Wheat, L. J., P. Connolly, N. Haddad, A. Le Monte, E. Brizendine, and R. Hafner. 2002. Antigen clearance during treatment of disseminated histoplasmosis with itraconazole versus fluconazole in patients with AIDS. Antimicrob. Agents Chemother. 46:248-250.
41. Willcox, M., A. Kervitsky, L. C. Watters, and T. E. King, Jr. 1988. Quantification of cells recovered by bronchoalveolar lavage. Comparison of cytocentrifuge preparations with the filter method. Am. Rev. Respir. Dis. 138: 74-80.
42. Woestenborghs, R., W. Lorreyne, and J. Heykants. 1987. Determination of itraconazole in plasma and animal tissues by high-performance liquid chromatography. J. Chromatogr. 413:332-337.
43. Zar, J. H. 1984, Multisample hypotheses: the analysis of variance. Multiple comparisons, p. 162-205. In J. H. Zar (ed.), Biostatistical analysis. Prentice-Hall, Englewood Cliffs, N.J.
44. Zhanel, G. G., D. G. Saunders, D. J. Hoban, and J. A. Karlowsky. 2001. Influence of human serum on antifungal pharmacodynamics with Candida albicans. Antimicrob. Agents Chemother. 45:2018-2022.