Effects of ochratoxin A on DNA repair in cultures of rat hepatocytes and porcine urinary bladder epithelial cells

Archives of Toxicology

Volumn 71, Issue 11, 1997, Pages 709-713

  Dörrenhaus, Angelika ^a   Föllmann, Wolfram ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

DNA repair; Ochratoxin A; Urinary bladder

Indexed keywords

OCHRATOXIN;

ANIMAL CELL; ARTICLE; BLADDER EPITHELIUM; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; EPITHELIUM CELL; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SWINE;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0030882061     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050449     Document Type: Article

References (22)

1. Bendele AM, Neal SB, Oberly TJ, Thompson CZ, Bewsey BJ, Hill LE, Rexroat MA, Carlton WW, Probst GS (1985) Evaluation of ochratoxin A for mutagenicity in a battery of bacterial and mammalian cell assays. Food Chem Toxicol 23: 911-918
2. Bianchi V, Zantedeschi A, Levis AG (1983) The scintillometric evaluation of DNA repair synthesis can be distorted by changes of thymidine pool radioactivity. Chem Biol Interact 43: 17-31
3. Butterworth BE, Ashby J, Bermudez E, Casciano D, Mirsalis J, Probst G, Williams G (1987) A protocol and guide for the in vitro rat hepatocyte DNA-repair assay. Mutat Res 189: 113-121
4. Ceovic S, Plestina R, Miletic-Medved M, Stavljenic A, Mitar J, Vukelic M (1991) Epidemiological aspects of Balkan endemic nephropathy in a typical focus in Yugoslavia. IARC Sci Publ 115: 5-10
5. Creppy EE, Kane A, Dirheimer G, Lagarge-Frayssinet C, Mousset F, Frayssinet C (1985) Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney. Toxicol Lett 28: 29-35
6. Degen G, Gerber MM, Obrecht-Pflumio S, Dirheimer G (1997) Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures. Arch Toxicol 71: 365-371
7. De Groene EM, Jahn A, Horbach GJ, Fink-Gremmels J (1996) Mutagenicity and genotoxicity of the mycotoxin ochratoxin A. Environ Toxicol Pharmacol 1: 21-16
8. Dirheimer G, Creppy EE (1991) Mechanism of action of ochratoxin A. IARC Sci Pub 115: 171-186
9. Föllmann W, Guhe C (1994) A cell culture model of isolated porcine urinary bladder epithelial cells for genotoxicity studies. Toxic in vitro 8: 763-765
10. Föllmann W, Petzinger E, Kinne RKH (1990) Alterations of bile acid and bumetanide uptake during culturinc of rat hepatocytes. Am J Physiol 258: C700-C712
11. Föllmann W, Hillebrand, Creppy EE, Bolt HM (1995) Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha. Arch Toxicol 69: 280-286
12. Guhe C, Föllmann W (1994) Growth and characterization of porcine urinary bladder epithelial cells in vitro. Am J Physiol 266: F298-F308
13. Guhe C, Degen GH, Schuhmacher U, Kiefer F, Föllmann W (1996) Drug metabolizing activities in porcine urinary bladder epithelial cell cultures (PUBEC). Arch Toxicol 70: 599-606
14. 3H]-label from low doses of radioactive ochratoxin A ingested by rats, and evidence for DNA single-strand breaks caused in liver and kidneys. Arch Toxicol 58: 219-224
15. Kuiper-Goodmann T, Scott PM (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2: 179-248
16. Mori H, Kawai K, Ohbayashi F, Kuniyasu T, Yamazaki M, Hamasaki T, Williams GM (1984) Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture DNA repair test using rat and mouse hepatocytes. Cancer Res 44: 2918-2923
17. Obrecht-Pflumio S, Grosse Y, Pfohl-Leszkowicz A, Dirheimer G (1996) Protection by indomethacin and aspirin against genotoxicity of ochratoxin A, particularly in the urinary bladder and kidney. Arch Toxicol 70: 244-248
18. Pfohl-Leszkowicz A, Grosse Y, Kane A, Creppy EE, Dirheimer G (1993) Differential DNA adduct formation and disappearance in three mice tissues after treatment by the mycotoxin ochratoxin A. Mutat Res 289: 265-273
19. Snyder RD (1984) The role of deoxynucleoside triphosphate pools in the inhibition of DNA-excision repair and replication in human cells by hydroxyurea. Mutat Res 131: 163-172
20. Sostaric B, Vulkelic M (1991) Characteristics of urinary tract tumours in the area of Balkan endemic nephropathy in Croatia. IARC Sci Publ 115: 29-35
21. Stich HF, San RHC (1970) DNA repair and chromatid anomalies in mammalian cells exposed to 4-nitroquinoline 1-oxide. Mutat Res 10: 389-404
22. Williams GM (1977) Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cultures. Cancer Res 37: 1845-1851