Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4895-4900

  Lee, Shoukou ^a   Shinji, Chihiro ^a   Ogura, Kiyoshi ^b   Shimizu, Motomu ^b   Maeda, Satoko ^c   Sato, Mayumi ^b   Yoshida, Minoru ^c   Hashimoto, Yuichi ^a   Miyachi, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c RIKEN   (Japan)

Author keywords

HDAC; HDAC inhibitor; Hydroxamic acid; Isoindoklinone; p21; Pancreatic cancer

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; DRUG DESIGN; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PANCREAS CANCER;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INDOLES; PANCREATIC NEOPLASMS; UP-REGULATION;

EID: 34547592204     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.038     Document Type: Article

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