Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis

Surgery

Volumn 142, Issue 2, 2007, Pages 295-302

  Baregamian, Naira ^a   Rychahou, Piotr G ^a   Hawkins, Hal K ^a   Evers, B Mark ^a,b   Chung, Dai H ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; EOSIN; GROWTH FACTOR; HEMATOXYLIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL FEEDING; ARTIFICIAL MILK; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; INTESTINE INJURY; MOUSE; NECROTIZING ENTEROCOLITIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, NEWBORN; ENTEROCOLITIS, NECROTIZING; FEMALE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INSULIN-LIKE GROWTH FACTOR I; INTESTINAL MUCOSA; MICE; PREGNANCY; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SURVIVAL RATE; UP-REGULATION;

EID: 34547590863     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2007.04.018     Document Type: Article

References (25)

1. Sibbons P., Spitz L., van Velzen D., and Bullock G.R. Relationship of birth weight to the pathogenesis of necrotizing enterocolitis in the neonatal piglet. Pediatr Pathol 8 (1988) 151-162
2. Schumacker P.T. Hypoxia-inducible factor-1 (HIF-1). Crit Care Med 33 (2005) S423-S425
3. Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14 (2000) 391-396
4. Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60 (2000) 1541-1545
5. Chandel N.S., Maltepe E., Goldwasser E., Mathieu C.E., Simon M.C., and Schumacker P.T. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A 95 (1998) 11715-11720
6. Chandel N.S., McClintock D.S., Feliciano C.E., Wood T.M., Melendez J.A., Rodriguez A.M., et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275 (2000) 25130-25138
7. Jiang B.H., Jiang G., Zheng J.Z., Lu Z., Hunter T., and Vogt P.K. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 12 (2001) 363-369
8. Sodhi A., Montaner S., Miyazaki H., and Gutkind J.S. MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF. Biochem Biophys Res Commun 287 (2001) 292-300
9. Chen E.Y., Mazure N.M., Cooper J.A., and Giaccia A.J. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res 61 (2001) 2429-2433
10. Mottet D., Dumont V., Deccache Y., Demazy C., Ninane N., Raes M., et al. Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J Biol Chem 278 (2003) 31277-31285
11. Zhou Y., Wang Q., Evers B.M., and Chung D.H. Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res 58 (2005) 1192-1197
12. Baregamian N., Song J., Jeschke M.G., Evers B.M., and Chung D.H. IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis. J Surg Res 136 (2006) 31-37
13. Giatromanolaki A., Sivridis E., Kouskoukis C., Gatter K.C., Harris A.L., and Koukourakis M.I. Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res 13 (2003) 493-501
14. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
15. Treins C., Giorgetti-Peraldi S., Murdaca J., Monthouel-Kartmann M.N., and Van Obberghen E. Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I. Mol Endocrinol 19 (2005) 1304-1317
16. Bardos J.I., and Ashcroft M. Negative and positive regulation of HIF-1: a complex network. Biochim Biophys Acta 1755 (2005) 107-120
17. Wang X., Deng J., Boyle D.W., Zhong J., and Lee W.H. Potential role of IGF-I in hypoxia tolerance using a rat hypoxic-ischemic model: activation of hypoxia-inducible factor 1alpha. Pediatr Res 55 (2004) 385-394
18. Chavez J.C., and LaManna J.C. Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1. J Neurosci 22 (2002) 8922-8931
19. Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., and Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277 (2002) 38205-38211
20. Burroughs K.D., Oh J., Barrett J.C., and DiAugustine R.P. Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible factor-1?. Mol Cancer Res 1 (2003) 312-322
21. Huang S.T., Vo K.C., Lyell D.J., Faessen G.H., Tulac S., Tibshirani R., et al. Developmental response to hypoxia. Faseb J 18 (2004) 1348-1365
22. Berra E., Ginouves A., and Pouyssegur J. The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep 7 (2006) 41-45
23. Corbucci G.G., Marchi A., Lettieri B., and Luongo C. Mechanisms of cell protection by adaptation to chronic and acute hypoxia: molecular biology and clinical practice. Minerva Anestesiol 71 (2005) 727-740
24. Greijer A.E., and van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 57 (2004) 1009-1014
25. Emerling B.M., Platanias L.C., Black E., Nebreda A.R., Davis R.J., and Chandel N.S. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol 25 (2005) 4853-4862