Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4967-4971

  Li, Xinming ^a   Tao Ng, Magdeline Tao ^a   Wang, Yifan ^a   Liu, Xiaoqian ^a   Li, Tianhu ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Circular oligonucleotides; Enzyme inhibitor; Human topoisomerase I; Stable hairpins

Indexed keywords

DNA; DNA TOPOISOMERASE; OLIGONUCLEOTIDE;

AGAR GEL ELECTROPHORESIS; ARTICLE; ENZYME INHIBITION; ENZYME SYNTHESIS; IC 50; NUCLEOTIDE SEQUENCE;

ANIONS; BASE PAIR MISMATCH; BASE SEQUENCE; BINDING SITES; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES;

EID: 34547522705     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.035     Document Type: Article

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