Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents

Pharmazie

Volumn 51, Issue 1, 1996, Pages 7-11

  Santagati, Maria ^a   Modica, Maria ^a   Santagati, A ^a   Russo, F ^a   Spampinato, S ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (4 CHLOROPHENYLAMINO) 3,4 DIHYDRO 5,6 DIMETHYLTHIENO [2,3 D]PYRIMIDIN 4(3H) ONE; 3 AMINO 4,6,7,8,9 HEXAHYDRO 2 PHENYLAMINOBENZO[B]THIENO [2,3 D]PYRIMIDIN 4 (3H) ONE; ANTICONVULSIVE AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROPHOTOMETRY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTICONVULSANTS; CHEMISTRY, PHYSICAL; MALE; MICE; MOTOR ACTIVITY; PYRIMIDINES; RATS; SEIZURES; THIOPHENES; TRIAZOLES;

EID: 0030065816     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Russo, F.; Santagati, A., Santagati, M.; Caruso, A.; Leone, M ; Felice, A.; Amico-Roxas, M.: Eur. J. Med. Chem. 24, 91 (1989)
2. Santagati, A.; Santagati, M.; Modica, M.: Heterocycles 36, 1315 (1993)
3. Santagati, A.; Modica, M.; Santagati, M ; Caruso, A.; Cutuli, V.: Pharmazie 49, 64 (1994)
4. Santagati, A.; Modica, M.; Santagati, M : J Heterocycl. Chem. 31, 1141 (1994)
5. Temple, D. L.; Yevich, J. P.; Covington, R. R.; Hanning, C. A.; Seidehamel, R. J.; Mackey, H K.; Bartck, M. J.: J. Med. Chem. 22, 505 (1978)
6. Fortea, J.: Afinidad 30, 225 (1973): C. A. 79, 105175v (1973)
7. Fortea, J.: Afinidad 30, 225 (1973): C. A. 79, 105175v (1973)
8. Pathak, U. S.; Gandhi, N. V.; Singh, S.; Warde, R. P.; Jain, K. S.: Indian J. Chem., Sect. B. 31B, 223 (1992)
9. Tully, W. R.; Westwood, R.; Rowlands, D A.; Clements-Jewery, S.: EP 76, 199 (1983); C. A. 99, 194989s (1983)
10. Yamamoto, M.; Morooka, S.; Koshiba, M., Inaba, S.; Yamamoto, H.: DP 2, 508, 333 (1974); C A. 83, 206322d (1975)
11. Hardtmann, G. E.; Kathawala, F. G.: USP 4.053, 600 (1977); C. A. 88, 22970k (1978)
12. Russo, F.; Guccione, S.; Romeo, G., Monsù Scolaro, L.; Pucci, S.; Caruso, A ; Cutuli, V.; Amico-Roxas, M.: Eur. J. Med. Chem. 27, 73 (1992)
13. Moreau, S ; Coudert, P ; Rubat, C.; Gardette, D., Vallee-Goyet, D.; Couquelet, J.; Bastide, P., Tronche, P.: J. Med. Chem. 37, 2153 (1994)
14. Davies-Jones, G. A. B ; in; Dukes. M. N. G (Ed.): Meyler's side effects of drugs. 11th ed. p. 120, Elsevier Science Publishers B. V. New York 1988
15. Gewald, K., Schinke, E.; Böttcher, H.: Chem. Ber. 99, 94 (1966)
16. Kienzle, F.; Kaiser, A.; Minder, R. E : Helv. Chim. Acta 66, 148 (1983)
17. Devani, M. B.; Shishoo, C. J.; Pathak, U. S.: Parikh, S. H.; Shah, G. F.; Padhya, A. C., J. Pharm. Sci. 65, 660 (1976)
18. Garin, J., Pilar Loscertales, M.; Melendez, E.; Merchan, F. L.; Rodriguez, R.; Tejero, T.: Heterocycles 26, 1303 (1987)
19. Litchfield, J. T., Wilcoxon, F. A.: J. Pharmacol. Exp. Ther. 96, 99 (1949)