Lineage specification of hematopoietic stem cells: Mathematical modeling and biological implications

Stem Cells

Volumn 25, Issue 7, 2007, Pages 1791-1799

  Glauche, Ingmar ^a   Cross, Michael ^b   Loeffler, Markus ^a   Roeder, Ingo ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Hematopoiesis; Lineage specification; Mathematical model; Simulation; Stem cells; Systems biology

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL KINETICS; CELL LINEAGE; CELL ORGANELLE; HEMATOPOIETIC STEM CELL; MATHEMATICAL MODEL; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; COMPUTER SIMULATION; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MODELS, BIOLOGICAL;

EID: 34547232294     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0025     Document Type: Article

References (43)

1. Suda T, Suda J, Ogawa M. Disparate differentiation in mouse hemopoietic colonies derived from paired progenitors. Proc Natl Acad Sci U S A 1984;81:2520-2524.
2. Leary AG, Strauss LC, Civin CI et al. Disparate differentiation in hemopoietic colonies derived from human paired progenitors. Blood 1985;66:327-332.
3. Cross MA, Enver T. The lineage commitment of haemopoietic progenitor cells. Curr Opin Genet Dev 1997;7:609-613.
4. Hu M, Krause D, Greaves M et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev 1997;11:774-785.
5. Enver T, Greaves M. Loops, lineage, and leukemia. Cell 1998;94:9-12.
6. Akashi K, He X, Chen J et al. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 2003;101:383-389.
7. Loeffler M, Roeder I. Tissue stem cells: Definition, plasticity, heterogeneity, self-organization and models - a conceptual approach. Cells Tissues Organs 2002;171:8-26.
8. Roeder I, Loeffler M. A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity. Exp Hematol 2002;30:853-861.
9. Roeder I, Loeffler M, Quesenberry PJ et al. Quantitative tissue stem cell modeling. Blood 2003;102:1143-1144; author reply 1144-1145.
10. Roeder I, Kamminga LM, Braesel K et al. Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization. Blood 2005;105:609-616.
11. Roeder I, Horn M, Glauche I et al. Dynamic modeling of imatinib-treated chronic myeloid leukemia: Functional insights and clinical implications. Nat Med 2006;12:1181-1184.
12. Roeder I, Lorenz R. Asymmetry of stem cell fate and the potential impact of the niche: Observations, simulations, and interpretations. Stem Cell Reviews 2007 (in press).
13. Takano H, Ema H, Sudo K et al. Asymmetric division and lineage commitment at the level of hematopoietic stem cells: Inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med 2004;199:295-302.
14. Mikkers H, Frisen J. Deconstructing stemness. EMBO J 2005;24:2715-2719.
15. Heyworth CM, Dexter TM, Kan O et al. The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells. Growth Factors 1990;2:197-211.
16. Heyworth CM, Alauldin M, Cross MA et al. Erythroid development of the FDCP-Mix A4 multipotent cell line is governed by the relative concentrations of erythropoietin and interleukin 3. Br J Haematol 1995;91:15-22.
17. Morrison SJ, Shah NM, Anderson DJ. Regulatory mechanisms in stem cell biology. Cell 1997;88:287-298.
18. Ho AD. Kinetics and symmetry of divisions of hematopoietic stem cells. Exp Hematol 2005;33:1-8.
19. Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006;441:1068-1074.
20. Gotz M, Huttner WB. The cell biology of neurogenesis. Nat Rev Mol Cell Biol 2005;6:777-788.
21. Lechler T, Fuchs E. Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 2005;437:275-280.
22. Hume DA. Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood 2000;96:2323-2328.
23. Akashi K. Lineage promiscuity and plasticity in hematopoietic development. Ann N Y Acad Sci 2005;1044:125-131.
24. Schroeder T. Tracking hematopoiesis at the single cell level. Ann N Y Acad Sci 2005;1044:201-209.
25. Dykstra B, Ramunas J, Kent D et al. High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal. Proc Natl Acad Sci U S A 2006;103:8185-8190.
26. Preisler HD, Kauffman S. A proposal regarding the mechanism which underlies lineage choice during hematopoietic differentiation. Leuk Res 1999;23:685-694.
27. Furusawa C, Kaneko K. Emergence of rules in cell society: Differentiation, hierarchy, and stability. Bull Math Biol 1998;60:659-687.
28. Furusawa C, Kaneko K. Theory of robustness of irreversible differentiation in a stem cell system: Chaos hypothesis. J Theor Biol 2001;209:395-416.
29. Cinquin O, Demongeot J. High-dimensional switches and the modelling of cellular differentiation. J Theor Biol 2005;233:391-411.
30. Laslo P, Spooner CJ, Warmflash A et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 2006;126:755-766.
31. Roeder I, Glauche I. Towards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1. J Theor Biol 2006;241:852-865.
32. Potten CS, Loeffler M. Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990;110:1001-1020.
33. Loeffler M, Potten CS. Stem cells and cellular pedigrees - a conceptual introduction. In: Potten CS, ed. Stem Cells. London: Academic Press, 1997:1-27.
34. Blau HM, Brazelton TR, Weimann JM. The evolving concept of a stem cell: Entity or function? Cell 2001;105:829-841.
35. Quesenberry PJ, Colvin GA, Lambert JF. The chiaroscuro stem cell: A unified stem cell theory. Blood 2002;100:4266-4271.
36. Theise ND, d'Inverno M. Understanding cell lineages as complex adaptive systems. Blood Cells Mol Dis 2004;32:17-20.
37. Kirkland MA. A phase space model of hemopoiesis and the concept of stem cell renewal. Exp Hematol 2004;32:511-519.
38. Zipori D. The stem state: Plasticity is essential, whereas self-renewal and hierarchy are optional. STEM CELLS 2005;23:719-726.
39. Kurakin A. Self-organization vs Watchmaker: Stochastic gene expression and cell differentiation. Dev Genes Evol 2005;215:46-52.
40. Abkowitz JL, Golinelli D, Harrison DE et al. In vivo kinetics of murine hemopoietic stem cells. Blood 2000;96:3399-3405.
41. Weissman IL. Stem cells: Units of development, units of regeneration, and units in evolution. Cell 2000;100:157-168.
42. Agur Z, Daniel Y, Ginosar Y. The universal properties of stem cells as pinpointed by a simple discrete model. J Math Biol 2002;44:79-86.
43. Prudhomme WA, Duggar KH, Lauffenburger DA. Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix. Biotechnol Bioeng 2004;88:264-272.