Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 22, 2007, Pages 9230-9235

  Chi, Seung Wook ^a   Maeng, Cheol Young ^a   Seung, Jun Kim ^a   Mee, Sook Oh ^a   Chun, Jeih Ryu ^a,b   Sang, Jick Kim ^a   Han, Kyou Hoon ^a   Hyo, Jeong Hong ^a   Seong, Eon Ryu ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Sejong University   (South Korea)

Author keywords

Alanine scanning mutagenesis; Crystal structure; Humanized antibody; Virus neutralization

Indexed keywords

HEPATITIS B ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY HXKR127; UNCLASSIFIED DRUG; VIRUS PROTEIN; ANTIGEN; PEPTIDE;

ALANINE SCANNING MUTAGENESIS; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; ARTICLE; CHEMICAL MUTAGENESIS; COMPLEMENTARITY DETERMINING REGION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EPITOPE MAPPING; HEPATITIS B VIRUS; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; VIRUS NEUTRALIZATION; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MUTATION; PROTEIN QUATERNARY STRUCTURE; SENSITIVITY AND SPECIFICITY; X RAY CRYSTALLOGRAPHY;

HEPATITIS B VIRUS;

AMINO ACID SEQUENCE; ANTIGENS; BINDING SITES; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; HEPATITIS B ANTIBODIES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN STRUCTURE, QUATERNARY; SENSITIVITY AND SPECIFICITY; VIRAL PROTEINS;

EID: 34547207674     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0701279104     Document Type: Article

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