Suppression of osteoclastogenesis by N,N-dimethyl-D-erythros-phingosine: A sphingosine kinase inhibition-independent action

Molecular Pharmacology

Volumn 72, Issue 2, 2007, Pages 418-428

  Hyung, Joon Kim ^a   Lee, Youngkyun ^a   Chang, Eun Ju ^a   Kim, Hyun Man ^a   Hong, Sam Pyo ^a   Zang, Hee Lee ^a   Ryu, Jiyoon ^a   Kim, Hong Hee ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N,N DIMETHYLSPHINGOSINE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; PROTEIN KINASE B; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE METASTASIS; CALCIUM SIGNALING; CANCER RESEARCH; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG RESEARCH; MACROPHAGE; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BONE MARROW CELLS; CALCIUM SIGNALING; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, INBRED ICR; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; OSTEOGENESIS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-FOS; RANK LIGAND; SPHINGOSINE;

EID: 34547207232     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.034173     Document Type: Article

References (43)

1. Alfonso A, De la Rosa LA, Vieytes MR, and Botana LM (2003) Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. Biochem Pharmacol 65:465-478.
2. Boyle WJ, Simonet WS, and Lacey DL (2003) Osteoclast differentiation and activation. Nature 423:337-342.
3. Edsall LC, Van Brocklyn JR, Cuvillier O, Kleuser B, and Spiegel S (1998) N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37:12892-12898.
4. Endo K, Igarashi Y, Nisar M, Zhou QH, and Hakomori S (1991) Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res 51:1613-1618.
5. Grønning LM, Cederberg A, Miura N, Enerback S, and Tasken K (2002) Insulin and TNF-α induce expression of the Forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK1/2-dependent pathway. Mol Endocrinol 16:873-883.
6. Ha H, Kwak HB, Lee SK, Na DS, Rudd CE, Lee ZH, and Kim HH (2003) Membrane rafts play a crucial role in receptor activator of nuclear factor kappaB signaling and osteoclast function. J Biol Chem 278:18573-18580.
7. Hamaguchi A, Suzuki E, Murayama K, Fujimura T, Hikita T, Iwabuchi K, Handa K, Withers DA, Masters SC, Fu H, et al. (2003) Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta. J Biol Chem 278:41557-41565.
8. Hannun YA and Bell RM (1987) Lysosphingolipids inhibit protein kinase C: implication for the sphingolipidoses. Science 235:670-674.
9. Huang C, Ma WY, and Dong Z (1996) Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Mol Cell Biol 16:6427-6435.
10. Huang H, Ryu J, Ha J, Chang EJ, Kim HJ, Kim HM, Kitamura T, Lee ZH, and Kim HH (2006) Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kB transactivation by RANKL. Cell Death Differ 13:1879-1891.
11. Igarashi Y and Hakomori S (1989) Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine:N- methyltransferase in mouse brain. Biochem Biophys Res Commun 164:1411-1416.
12. Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, and Spiegel S (1998) Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem 273:23722-23728.
13. Lee C, Tomkowicz B, Freedman BD, and Collman RG (2005) HIV-1 gp120-induced TNF-μ production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathway. J Leukocyte Biol 78:1016-1023.
14. 2+) in human monocytes. J Pharmacol Sci 100:289-296.
15. Lee ZH and Kim HH (2003) Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts. Biochem Biophys Res Commun 305:211-214.
16. Matsumoto M, Sudo T, Saito T, Osada H, and Tsujimoto M (2000) Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kB ligand (RANKL). J Biol Chem 275:31155-31161.
17. Matsuo K and Ray N (2004) Osteoclasts, mononuclear phagocytes, and c-Fos: new insight into osteoimmunology. Keio J Med 53:78-84.
18. Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, et al. (2004) Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem 279:26475-26480.
19. 2+ signals, enzyme release, cytokine production, and chemotaxis. J Immunol 173:1596-1603.
20. Monick MM, Cameron K, Powers LS, Butler NS, McCoy D, Mallampalli RK, and Hunninghake GW (2004) Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am J Respir Cell Mol Biol 30:844-852.
21. Moonga BS and Dempster DW (1998) Effects of peptide fragments of protein kinase C on isolated rat osteoclasts. Exp Physiol 83:717-725.
22. Müller JM, Krauss B, Kaltschmidt C, Baeuerle PA, and Rupec RA (1997) Hypoxia induces c-Fos transcription via a mitogen-activated protein kinase-dependent pathway. J Biol Chem 272:23435-23439.
23. Mundy GR (2002) Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2:584-593.
24. Olivera A and Spiegel S (1993) Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365:557-560.
25. Payne DM, Rossomando AJ, Martino P, Erikson AK, Her JH, Shabanowitz J, Hunt DF, Weber MJ, and Sturgill TW (1991) Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J 10:885-892.
26. Pearson G, Robinson F, Gibson TB, Xu B, Karandikar M, Berman K, and Cobb MH (2001) Mitogen-activated protein kinase pathway: regulation and physiological functions. Endocr Rev 22:153-183.
27. Ryu J, Kim HJ, Chang EJ, Huang H, Banno Y, and Kim HH (2006) Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. EMBO J 25:5840-5851.
28. Shu X, Wu W, Mosteller RD, and Broek D (2002) Sphingosine kinase mediates vascular endothelial growth factor-induced activation of Ras and mitogen-activated protein kinases. Mol Cell Biol 22:7758-7768.
29. Spiegel S and Milstien S (2003) Sphingosine-1-phosphate: an enigmatic signaling lipid. Nat Rev Mol Cell Biol 4:397-407.
30. Takatsuna H, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Sato H, Aoki K, Ohya K, Takayanagi H, et al. (2005) Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1. J Bone Miner Res 20:653-662.
31. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, et al. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3:889-901.
32. Tauzin L, Graf C, Sun M, Rovina P, Bouveyron N, Jaritz M, Winiski A, Hartmann N, Staedtler F, Billich A, et al. (2007) Effects of ceramide-1-phosphate on cultured cells: dependence on dodecane in the vehicle. J Lipid Res 48:66-76.
33. Teitelbaum SL (2004) RANKing c-Jun in osteoclast development. J Clin Invest 114:463-465.
34. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8:205-215.
35. Walsh MC, Kim N, Kadono Y, Rho J, Lee SY, Lorenzo J, and Choi Y (2006) Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol 24:33-63.
36. Wang C, Steer JH, Joyce DA, Yip KH, Zheng MH, and Xu J (2003) 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation. J Bone Miner Res 18:2159-2168.
37. Wei S, Wang MW, Teitelbaum SL, and Ross FP (2002) Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling. J Biol Chem 277:6622-6630.
38. Wilden PA, Agazie YM, Kaufman R, and Halenda SP (1998) ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways. Am J Physiol 275:H1209-H1215.
39. Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, and Choi Y (1999) TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell 4:1041-1049.
40. Wu W, Mosteller RD, and Broek D (2004) Sphingosine kinase protects lipopolysaccharide-activated macrophages from apoptosis. Mol Cell Biol 24:7359-7369.
41. Xia P, Wang L, Gamble JR, and Vadas MA (1999) Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J Biol Chem 274:34499-34505.
42. Yadav M, Clark L, and Schorey JS (2006) Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase. J Immunol 176:5494-5503.
43. Zhuang ZY, Xu H, Clapham DE, and Ji RR (2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci 24:8300-8309.