Lipopolysaccharide (LPS) directly suppresses growth hormone receptor (GHR) expression through MyD88-dependent and -independent Toll-like receptor-4/MD2 complex signaling pathways

Molecular and Cellular Endocrinology

Volumn 274, Issue 1-2, 2007, Pages 35-42

  Dejkhamron, Prapai ^a   Thimmarayappa, Jamuna ^a   Kotlyarevska, Kateryna ^a   Sun, Jinhong ^a   Lu, Chunxia ^a   Bonkowski, Erin L ^b   Denson, Lee A ^b   Menon, Ram K ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Growth hormone receptor; LPS; Sepsis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; CYTOKINE; FATTY ACID; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; LIPID A; MYELOID DIFFERENTIATION FACTOR 88; POLYMYXIN B; PROTEIN MD 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL STRAIN HEK293; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEPSIS; SIGNAL TRANSDUCTION; SUPERNATANT;

ANIMALS; ANTIGENS, CD14; CELL LINE; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MICE; MULTIPROTEIN COMPLEXES; MYELOID DIFFERENTIATION FACTOR 88; PROMOTER REGIONS (GENETICS); RECEPTORS, SOMATOTROPIN; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 34547180376     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.05.013     Document Type: Article

References (29)

1. Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 (2004) 499-511
2. Bhor V.M., Thomas C.J., Surolia N., and Surolia A. Polymyxin B: an ode to an old antidote for endotoxic shock. Mol. Biosyst. 1 (2005) 213-222
3. Burns K., Martinon F., Esslinger C., Pahll H., Schneider P., Bodmer J.-L., Di Marco F., French L., and Tschopp J. MyD88, an adapter protein Involved in Interleukin-1 signaling. J. Biol. Chem. 273 (1998) 12203-12209
4. Carroll P.V., and Van den Berghe G. Safety aspects of pharmacological GH therapy in adults. Growth Horm. IGF Res. 11 (2001) 166-172
5. Chen Z.J. Ubiquitin signalling in the NF-[kappa]B pathway. Nat. Cell Biol. 7 (2005) 758-765
6. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
7. Denson L.A., Held M.A., Menon R.K., Frank S.J., Parlow A.F., and Arnold D.L. Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3. Am. J. Physiol. Gastrointest. Liver Physiol. 284 (2003) G646-G654
8. Denson L.A., Menon R.K., Shaufl A., Bajwa H.S., Williams C.R., and Karpen S.J. TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding. J. Clin. Invest. 107 (2001) 1451-1458
9. Denson L.A., Shaufl A., Karpen S.J., and Menon R.K. Tumor necrosis factor alpha down regulates murine hepatic growth hormone receptor gene expression via inhibition of Sp1 and Sp3 binding. J. Clin. Invest. 107 (2001) 1451-1458
10. Edens A., and Talamantes F. Alternative processing of growth hormone receptor transcripts. Endocr. Rev. 19 (1998) 559-582
11. Fitzgerald K.A., Rowe D.C., and Golenbock D.T. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 6 (2004) 1361-1367
12. Imler J.-L., and Zheng L. Biology of Toll receptors: lessons from insects and mammals. J. Leukoc. Biol. 75 (2004) 18-26
13. Lee J.Y., Ye J., Gao Z., Youn H.S., Lee W.H., Zhao L., Sizemore N., and Hwang D.H. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J. Biol. Chem. 278 (2003) 37041-37051
14. Lynn W.A., and Golenbock D.T. Lipopolysaccharide antagonists. Immunol. Today 13 (1992) 271-276
15. Menon R., Cheng H., and Singh M. Identification and characterization of single strand DNA-binding protein that represses growth hormone receptor gene expression. Mol. Endocrinol. 11 (1997) 1291-1304
16. Menon R.K., Stephan D.A., Singh M., Morris Jr. S.M., and Zou L. Cloning of the promoter-regulatory region of the murine growth hormone receptor gene. Identification of a developmentally regulated enhancer element. J. Biol. Chem. 270 (1995) 8851-8859
17. Miyake K. Roles for accessory molecules in microbial recognition by Toll-like receptors. J. Endotoxin Res. 12 (2006) 195-204
18. Moffat J.G., Edens A., and Talamantes F. Structure and expression of the mouse growth hormone receptor/growth hormone binding-protein gene. J. Mol. Endocrinol. 23 (1999) 33-44
19. Palsson-McDermott E.M., and O'Neill L.A.J. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113 (2004) 153-162
20. Rhee S.H., and Hwang D. Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NFkappa B and expression of the inducible cyclooxygenase. J. Biol. Chem. 275 (2000) 34035-34040
21. Schromm A.B., Lien E., Henneke P., Chow J.C., Yoshimura A., Heine H., Latz E., Monks B.G., Schwartz D.A., Miyake K., and Golenbock D.T. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J. Exp. Med. 194 (2001) 79-88
22. Schwartzbauer G., Yu J.H., Cheng H., and Menon R.K. Transcription factor MSY-1 regulates expression of the murine growth hormone receptor gene. J. Biol. Chem. 273 (1998) 24760-24769
23. Southard J.N., Barrett B.A., Bikbulatova L., Ilkbahar Y., Wu K., and Talamantes F. Growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids with alternative 5′-untranslated regions are differentially expressed in mouse liver and placenta. Endocrinology 136 (1995) 2913-2921
24. Takala J., Ruokonen E., Webster N.R., Nielsen M.S., Zandstra D.F., Vundelinckx G., and Hinds C.J. Increased mortality associated with growth hormone treatment in critically ill adults. N. Engl. J. Med. 341 (1999) 785-792
25. Thimmarayappa J., Sun J., Schultz L.E., Dejkhamron P., Lu C., Giallongo A., Merchant J.L., and Menon R.K. Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor ZBP-89. Mol. Endocrinol. 20 (2006) 2747-2760
26. Trent M., Stead C., Tran A., and Hankins J. Diversity of endotoxin and its impact on pathogenesis. J. Endotoxin Res. 12 (2006) 205-223
27. Wang P., Li N., Li J.S., and Li W.Q. The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity. World J. Gastroenterol. 8 (2002) 531-536
28. Yu J.H., Schwartzbauer G., Kazlman A., and Menon R.K. Role of the Sp family of transcription factors in the ontogeny of growth hormone receptor gene expression. J. Biol. Chem. 274 (1999) 34327-34336
29. Yumet G., Shumate M., Bryant D., Lang C., and Cooney R. Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling. Crit. Care Med. 34 (2006) 1420-1427