Endocytic Pathways for 25-(OH) Vitamin D3

Vitamin D

Volumn 1, Issue , 2005, Pages 153-163

  Willnow, Thomas E ^a   Nykjaer, Anders ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34547169941     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012252687-9/50013-9     Document Type: Chapter

References (79)

1. Fraser DR, Kodicek E Unique biosynthesis by kidney of a biological active vitamin D metabolite. Nature 1970, 228:764-766.
2. Gray R, Boyle I, DeLuca HF Vitamin D metabolism: the role of kidney tissue. Science 1971, 172:1232-1234.
3. Lawson DE, Fraser DR, Kodicek E, Morris HR, Williams DH Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism. Nature 1971, 230:228-230.
4. Holick MF, Schnoes HK, DeLuca HF, Suda T, Cousins RJ Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. Biochemistry 1971, 10:2799-2804.
5. 3 synthesis in the kidney. Nature 1978, 276:287-289.
6. 3 1α-hydroxylase and 24-hydroxylase along the rat nephron. Proc Natl Acad Sci USA 1981, 78:1199-1203.
7. 3-1α-hydroxylase. J Biol Chem 1985, 260:11488-11492.
8. 3-1α-hydroxylase along the nephron: new insights into renal vitamin D metabolism. Curr Opin Nephrol Hypertens 2000, 9:17-22.
9. Brown AJ, Dusso A, Slatopolsky E Vitamin D. Am J Physiol 1999, 277:F157-F175.
10. Daiger SP, Schanfield MS, Cavalli-Sforza LL Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc Natl Acad Sci USA 1975, 72:2076-2080.
11. Haddad JG Plasma vitamin D-binding protein (Gc-globulin): multiple tasks. J Steroid Biochem Mol Biol 1995, 53:579-582.
12. White P, Cooke N The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab 2000, 11:320-327.
13. Goldstein DA, Oda Y, Kurokawa K, Massary SG Blood levels of 25-hydroxyvitamin D in nephrotic syndrome. Studies in 26 patients. Ann Intern Med 1977, 87:664-667.
14. Barragry JM, France MW, Carter ND, Auton JA, Beer M, Boucher BJ, Cohen RD Vitamin-D metabolism in nephrotic syndrome. Lancet 1977, 24:629-632.
15. Colston K, Williams NJ, Cleeve HJ Studies on vitamin D binding protein in the nephrotic syndrome. Clin Chem 1985, 31:718-721.
16. Mizokuchi M, Kubota M, Tomino Y, Koide H Possible mechanism of impaired calcium and vitamin D metabolism in nephrotic rats. Kidney Int 1992, 42:335-340.
17. Harrison HE The Fanconi syndrome. J Chron Dis 1953, 7:346-355.
18. Teranishi H, Kasuya M, Aoshima K, Kato T, Migita S Demonstration of vitamin D-binding protein (Ge-globulin) in the urine of Itai-itai disease patients. Toxicol Lett 1983, 15:7-12.
19. 3. Proc Natl Acad Sci USA 2001, 98:13895-13900.
20. Leheste JR, Rolinski B, Vorum H, Hilpert J, Nykjaer A, Jacobsen C, Aucouturier P, Moskaug JO, Otto A, Christensen EI, Willnow TE Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 1999, 155:1361-1370.
21. St John A, Thomas MB, Davies CP, Mullan B, Dick I, Hutchison B, van der Schaff A, Prince RL Determinants of intact parathyroid hormone and free 1,25-dihydroxyvitamin D levels in mild and moderate renal failure. Nephron 1992, 61:422-427.
22. Orlando RA, Farquhar MG Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex. Proc Natl Acad Sci USA 1993, 90:4082-4086.
23. Christensen EI, Nielsen S, Moestrup SK, Borre C, Maunsbach AB, de Heer E, Ronco P, Hammond TG, Verroust P Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. EJCB 1995, 66:349-364.
24. Christensen EI, Willnow TE Essential role of megalin in renal proximal tubule for vitamin homeostasis. J Am Soc Nephrol 1999, 10:2224-2236.
25. 3. Cell 1999, 96:507-515.
26. Christensen EI, Moskaug JO, Vorum H, Jacobsen C, Gundersen TE, Nykjaer A, Blomhoff R, Willnow TE, Moestrup SK Evidence for an essential role of megalin in transepithelial transport of retinol. J Am Soc Nephrol 1999, 10:685-695.
27. 12. Am J Physiol Renal Physiol 2002, 282:F408-F416.
28. 3 metabolism. Kidney Int 2002, 62:1672-1681.
29. Leheste JR, Melsen F, Wellner M, Jansen P, Schlichting U, Renner-Muller I, Andreassen TT, Wolf E, Bachmann S, Nykjaer A, Willnow TE Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J 2003, 17:247-249.
30. Haddad JG, Fraser DR, Lawson DE Vitamin D plasma binding protein. Turnover and fate in the rabbit. J Clin Invest 1981, 67:1550-1560.
31. Safadi FF, Thornton P, Magiera H, Hollis BW, Gentile M, Haddad JG, Liebhaber SA, Cooke NE Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest 1999, 103:239-251.
32. Mendel CM The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 1989, 10:232-274.
33. Christensen EI, Gliemann J, Moestrup SK Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein. J Histochem Cytochem 1992, 40:1481-1490.
34. Bikle DD, Gee E Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes. Endocrinology 1989, 124:649-654.
35. Vanham G, Van Baelen H, Tan BK, Bouillon R The effect of vitamin D analogs and of vitamin D-binding protein on lymphocyte proliferation. J Steroid Biochem 1988, 29:381-386.
36. 3 by cultured intestinal epithelial cells. J Steroid Biochem 1984, 20:857-862.
37. 3. Biochem Biophys Res Commun 1980, 95:596-602.
38. 3 and vitamin D binding protein by cultured porcine kidney cells (LLC-PKI). Int J Biochem 1991, 23:1225-1230.
39. Wu S, Ren S, Chen H, Chun RF, Gacad MA, Adams JS Intracellular vitamin D binding proteins: novel facilitators of vitamin D-directed transactivation. Mol Endocrinol 2000, 14:1387-1397.
40. Kerjaschki D, Miettinen A, Farquhar MG Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane. J Exp Med 1987, 166:109-128.
41. Yamazaki H, Ullrich R, Exner M, Saito A, Orlando RA, Kerjaschki D, Farquhar MG All four putative ligand-binding domains in megalin contain pathogenic epitopes capable of inducing passive Heymann nephritis. J Am Soc Nephrol 1998, 9:1638-1644.
42. http://www.ncbi.nlm.nih.gov/cgi_bin/Entrez.
43. Saito A, Pietromonaco S, Loo AK, Farquhar MG Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA 1994, 11:9725-9729.
44. Yochem J, Greenwald I A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans. Proc Natl Acad Sci USA 1993, 90:4572-4576.
45. 2+-binding receptor with potential intracellular signaling properties. Eur J Biochem 1996, 239:132-137.
46. Willnow TE, Nykjaer A, Herz J Lipoprotein receptors: new roles for ancient proteins. Nat Cell Biol 1999, 1:E157-E162.
47. Orlando RA, Exner M, Czekay R-P, Yamazaki H, Saito A, Ullrich R, Kerjaschki D, Farquhar MG Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions. Proc Natl Acad Sci USA 1997, 94:2368-2373.
48. Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J Structure of the LDL receptor extracellular domain at endosomal pH. Science 2002, 298:2353-2358.
49. Kibbey RG, Rizo J, Gierasch LM, Anderson RG The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation. J Cell Biol 1998, 142:59-67.
50. Oleinikov AV, Zhao J, Makker SP Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Biochem J 2001, 347:613-621.
51. Nykjaer A, Willnow TE The low-density lipoprotein receptor gene family: a cellular Swiss army knife?. Trends Cell Biol 2002, 12:273-280.
52. Willnow TE, Hilpert J, Armstrong SA, Rohlmann A, Hammer RE, Burns DK, Herz J Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA 1996, 93:8460-8464.
53. Fass D, Blacklow S, Kim PS, Berger JM Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature 1997, 388:691-693.
54. Christensen EI, Birn H, Verroust P, Moestrup SK Membrane receptors for endocytosis in the renal proximal tubules. Int Rev Cytol 1998, 180:237-284.
55. Seetharam B, Levine JS, Ramasamy M, Alpers DH Purification, properties, and immunochemical localisation of a receptor for intrinsic factor-cobalamin receptor in the rat kidney. J Biol Chem 1988, 263:4443-4449.
56. 12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region. Blood 1998, 91:3593-3600.
57. 12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J Biol Chem 1998, 273:5235-5242.
58. Xu D, Kozyraki R, Newman TC, Fyfe JC Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption. Blood 1999, 94:3604-3606.
59. 12 receptor, cubilin, discloses regions important for membrane association and ligand binding. J Biol Chem 1999, 274:20540-20544.
60. Burmeister R, Boe IM, Nykjaer A, Jacobsen C, Moestrup SK, Verroust P, Christensen EI, Lund J, Willnow TE A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney. J Biol Chem 2001, 276:13295-13301.
61. Birn H, Fyfe JC, Jacobsen C, Mounier F, Verroust PJ, Orskov H, Willnow TE, Moestrup SK, Christensen EI Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 2000, 105:1353-1361.
62. Sahali D, Mulliez N, Chatelet F, Dupuis R, Ronco P, Verroust P Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of specific monoclonal antibodies. J Exp Med 1988, 167:213-218.
63. Aminoff M, Carter JE, Chadwick RB, Johnson C, Grasbeck R, Abdelaal MA, Broch H, Jenner LB, Verroust PJ, Moestrup SK, de la Chapelle A, Krahe R Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1. Nat Genet 1999, 21:309-313.
64. Imerslund O Idiopathic chronic megaloblastemic anemia in children. Acta Paediatr 1960, 49:208-209.
65. Kozyraki R, Fyfe J, Verroust PJ, Jacobsen C, Dautry-Varsat A, Gburek J, Willnow TE, Christensen EI, Moestrup SK Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proc Natl Acad Sci USA 2001, 98:12491-12496.
66. 3. Curr Opin Lipidol 2002, 13:255-260.
67. Bansal A, Gierasch LM The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation. Cell 1991, 67:1195-1201.
68. Morris SM, Tallquist MD, Rock CO, Cooper JA Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J 2002, 21:1555-1564.
69. Pook MA, Wrong O, Wooding C, Norden AG, Feest TG, Thakker RV Dent's disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22. Hum Mol Genet 1993, 2:2129-2134.
70. Lloyd SE, Pearce SH, Fisher SE, Steinmeyer K, Schwappach B, Scheinman SJ, Harding B, Bolino A, Devoto M, Goodyer P, Rigden SP, Wrong O, Jentsch TJ, Craig IW, Thakker RV A common molecular basis for three inherited kidney stone diseases. Nature 1996, 379:445-449.
71. Igarashi T, Gunther W, Sekine T, Inatomi J, Shiraga H, Takahashi S, Suzuki J, Tsuru N, Yanagihara T, Shimazu M, Jentsch TJ, Thakker RV Functional characterization of renal chloride channel. CLCN5, mutations associated with Dent's Japan disease. Kidney Int 1998, 54:1850-1860.
72. Yamamoto K, Cox JP, Friedrich T, Christie PT, Bald M, Houtman PN, Lapsley MJ, Patzer L, Tsimaratos M, van't Hoff WG, Yamaoka K, Jentsch TJ, Thakker RV Characterization of renal chloride channel (CLCN5) mutations in Dent's disease. J Am Soc Nephrol 2000, 11:1460-1468.
73. Gunther W, Luchow A, Cluzeaud F, Vandewalle A, Jentsch TJ CIC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells. Proc Natl Acad Sci USA 1998, 95:8075-8080.
74. --channel disruption impairs endocytosis in a mouse model for Dent's disease. Nature 2000, 408:369-373.
75. Napoli JL Biochemical pathways of retinoid transport, metabolism, signal transduction. Clin Immunol Immunopathol 1996, 80:S52-S62.
76. Ouahchi K, Arita M, Kayden H, Hentati F, Ben Hamida M, Sokol R, Arai H, Inoue K, Mandel JL, Koenig M Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet 1995, 9:141-145.
77. Adams JS, Chen H, Chun RF, Nguyen L, Wu S, Ren SY, Barsony J, Gacad MA Novel regulators of vitamin D action and metabolism: lessons learned at the Los Angeles zoo. J Cell Biochem 2003, 88:308-314.
78. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 1986, 63:954-959.
79. Bikle DD, Siiteri PK, Ryzen E, Haddad JG Serum protein binding of 1,25-dihydroxyvitamin D; a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab 1985, 61.