Effects of increased endogenous serotonin on the in vivo binding of [ 11C]DASB to serotonin transporters in conscious monkey brain

Synapse

Volumn 61, Issue 9, 2007, Pages 724-731

  Yamamoto, Shigeyuki ^a,b   Onoe, Hirotaka ^c   Tsukada, Hideo ^d   Watanabe, Yasuyoshi ^a,c  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Japan Science and Technology Agency   (Japan)

^d HAMAMATSU PHOTONICS K K   (Japan)

Author keywords

5 hydroxy L tryptophan; 11C DASB; PET; Serotonin transporter (SERT)

Indexed keywords

3 AMINO 4 (2 DIMETHYLAMINOMETHYLPHENYLSULFANYL)BENZONITRILE C 11; 5 HYDROXYTRYPTOPHAN; AMINO ACID DECARBOXYLASE; SEROTONIN; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; DEVICE; ENZYME ACTIVITY; MACACA; MALE; MICRODIALYSIS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PUTAMEN;

ANIMALS; BENZYLAMINES; BINDING, COMPETITIVE; BRAIN; CARBON ISOTOPES; MACACA MULATTA; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; WAKEFULNESS;

EID: 34547145802     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20422     Document Type: Article

References (35)

1. Arango V, Underwood MD, Mann JJ. 2002. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 136:443-453.
2. Bel N, Artigas F. 1996. Reduction of serotonergic function in rat brain by tryptophan depletion: Effects in control and fluvoxamine-treated rats. J Neurochem 67:669-676.
3. 11C]labelled L-tyrosine, L-dopa, L-tryptophan and 5-hydroxy-L-tryptophan. Acta Chem Scand 44:178-182.
4. Carpenter LL, Anderson GM, Pelton GH, Gudin JA, Kirwin PD, Price LH, Heninger GR, McDougle CJ. 1998. Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology 19:26-35.
5. 11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats. Synapse 47:123-133.
6. 11C]5-hydroxy- L-tryptophan for positron emission tomography assessment of serotonin synthesis in human brain. J Cereb Blood Flow Metab 22:1352-1366.
7. 11C]AFM. J Cereb Blood Flow Metab 22:1377-1398.
8. 11C] WAY 100635 to 5-HT(1A) receptors in rat brain, assessed using in vivo microdialysis and PET after fenfluramine. Synapse 41:150-159.
9. Hummerich R, Reischl G, Ehrlichmann W, Machulla HJ, Heinz A, Schloss P. 2004. DASB-in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer. J Neurochem 90:1218-1226.
10. 11C](+)McN5652. Biol Psychiatry 51:715-722.
11. 11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23:1096-1112.
12. 11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. J Neurosci 26:4638-4643.
13. 11C]DASB: Test-retest reproducibility using a multilinear reference tissue parametric imaging method. J Nucl Med 47:208-214.
14. 11C]DASB for measuring endogenous serotonin with PET: Binding studies. Nucl Med Biol 32:129-136.
15. 11C]-tryptophan/PET method for probing the decarboxylase step in serotonin synthesis. Synapse 59:521-531.
16. McCann UD, Szabo Z, Scheffel U, Dannals RF, Ricaurte GA. 1998. Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. Lancet 352:1433-1437.
17. 11C]DASB PET imaging study. Am J Psychiatry 158:1843-1849.
18. Meyer JH, Houle S, Sagrati S, Carella A, Hussey DF, Ginovart N, Goulding V, Kennedy J, Wilson AA. 2005. Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: Effects of major depressive episodes and severity of dysfunctional attitudes. Arch Gen Psychiatry 61:1271-1279.
19. 11C]-DASB to the serotonin transporter in baboons: Response to acute serotonin deficiency. Biol Psychiatry 57:102-106.
20. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ. 1984. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 15:217-227.
21. Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, de Montigny C, Blier P, Diksic M. 1997. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 94:5308-5313.
22. 11C]DASB and positron emission tomography. Biol Psychiatry 59:821-828.
23. Patlak CS, Blasberg RG, Fenstermacher JD. 1983. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7.
24. Praschak-Rieder N, Wilson AA, Hussey D, Carella A, Wei C, Ginovart N, Schwarz MJ, Zach J, Houle S, Meyer JH. 2005. Effects of tryptophan depletion on the serotonin transporter in healthy humans. Biol Psychiatry 58:825-830.
25. Ramamoorthy S, Blakely RD. 1999. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 285:763-766.
26. Stancampiano R, Melis F, Sarais L, Cocco S, Cugusi C, Fadda F. 1997. Acute administration of a tryptophan-free amino acid mixture decreases 5-HT release in rat hippocampus in vivo. Am J Physiol 272:R991-R994.
27. 11C]-DASB as serotonin transporter radioligands under various experimental conditions. J Nucl Med 43:678-692.
28. Takechi H, Onoe H, Imamura K, Onoe K, Kakiuchi T, Nishiyama S, Yoshikawa E, Mori S, Kosugi T, Okada H. 1994. Brain activation study by use of positron emission tomography in unanesthetized monkeys. Neurosci Lett 182:279-282.
29. 11C]DASB in healthy humans. Synapse 55:164-175.
30. Tao R, Auerbach SB. 1994. Anesthetics block morphine-induced increases in serotonin release in rat CNS. Synapse 18:307-314.
31. 2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: PET studies with microdialysis in the conscious monkey brain. J Neurosci 20:7067-7073.
32. 1 receptor binding and decreased working memory performance produced by repeated pretreatment with MK-801: A PET study in conscious monkeys. Neuropsychopharmacology 30:2144-2153.
33. Watanabe M, Okada H, Shimizu K, Omura T, Yoshikawa E, Kosugi T, Mori S, Yamashita T. 1997. A high resolution animal PET scanner using compact PS-PMT detectors. IEEE Trans Nucl Sci 44:1277-1282.
34. 11]C-labeled 2-(phenylthio)araalkylamines. J Med Chem 43:3103-3110.
35. Yamamoto S, Ouchi Y, Onoe H, Yoshikawa E, Tsukada H, Takahashi H, Iwase M, Yamaguti K, Kuratsune H, Watanabe Y. 2004. Reduction of serotonin transporters of patients with chronic fatigue syndrome. Neuroreport 15:2571-2574.