Inhibition of the hepatocarcinogenicity of aflatoxin B1 in rats by low levels of the phenolic antioxidants butylated hydroxyanisole and butylated hydroxytoluene

Cancer Letters

Volumn 104, Issue 1, 1996, Pages 49-53

  Williams, Gary M ^a   Iatropoulos, Michael J ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

Aflatoxin B1; Butylated hydroxyanisole; Butylated hydroxytoluene; Hepatocarcinogenicity

Indexed keywords

AFLATOXIN B1; ANTIOXIDANT; BUTYLATED HYDROXYANISOLE; BUTYLCRESOL; GLUTATHIONE TRANSFERASE; LIVER ENZYME; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029949304     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04228-0     Document Type: Article

References (19)

1. Wattenberg, L.W. (1985) Chemoprevention of cancer. Cancer Res., 45, 1-8.
2. Williams, G.M. (1993) Inhibition of chemical-induced experimental cancer by synthetic phenolic antioxidants. In: Antioxidants: Chemical, Physiological, Nutritional and Toxicological Aspects, pp. 302-308. Editors: G.M. Williams, H. Sies, G.T. Baker III, J.W. Erdman, Jr. and C.J. Henry. Princeton Scientific Press, Princeton, NJ.
3. Talalay, P. and Benson, A.M. (1982) Elevation of quinone reductase activity by anticarcinogenic antioxidants. Adv. Enzyme Regul., 20, 28-300.
4. Tanaka, T., Maruyama, H., Maeura, Y., Weisburger, J.H. and Williams, G.M. (1991) Modulation by butylated hydroxytoluene of liver and bladder carcinogenesis induced by chronic low level exposure to 2-acetylaminofluorene. Cancer Res., 51, 6224-6230.
5. Furukawa, K., Maeura, Y., Furukawa, N.T. and Williams, G.M. (1984) Induction by butylated hydroxytoluene of rat liver gamma-glutamyl transpeptidase activity in comparison to expression in carcinogen-induced altered lesions. Chem.-Biol. Interact., 48, 43-58.
6. 1 induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene. Carcinogenesis, 7, 1043-1050.
7. International Agency for Research on Cancer (1986) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some Naturally Occurring and Synthetic Food Components, Vol. 40, pp. 123-206. IARC, Lyon, France.
8. Shimizu, A., Nakamura, Y., Harada, M., Ono, T., Sato, K., Inone, T. and Kawisawa, M. (1989) Positive foci of glutathione-S-transferase placental form in the liver of rats given furfural by oral administration. Jpn. J. Cancer Res., 80, 608-611.
9. Williams, G.M. and Watanabe, K. (1978) Enhancement of hyperplastic lesions in the rat liver by the tumor promoter phenobarbital. In: Carcinogenesis, Vol. 2, Mechanisms of Tumor Promotion and Cocarcinogensis, pp. 449-451. Editors: T.J. Slaga, A. Sivak and R.K. Boutwell. Raven Press, New York.
10. Scheffe, H. (1959) The Analysis of Variance. Wiley, New York.
11. 1-induced carcinogenesis. J. Natl. Cancer Inst., 55, 579-588.
12. Williams, G.M (1982) Phenotypic properties of preneoplastic rat liver lesions and applications to detection of carcinogens and tumor promoters. Toxicol. Pathol., 10, 3-10.
13. Bannasch, P. (1986) Preneoplastic lesions as endpoints in carcinogenicity testing 1. Hepatic preneoplasia. Carcinogenesis, 7, 689-695.
14. Umemura, T., Tokumo, K., Gebhardt, R., Poirier, M. and Williams, G.M. (1993) Dose response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver. Cancer Lett., 73, 1-10.
15. Moore, M.A., Nakagawa, K., Satoh, K., Ishikawa, T. and Sato, K. (1987) Single GST-P positive liver cells - putative initiated hepatocytes. Carcinogenesis, 8, 482-486.
16. Gebhardt, R., Tanaka, T. and Williams, G.M. (1989) Glutamine synthetase heterogenous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations. Carcinogenesis, 10, 1917-1923.
17. Gebhardt, R. and Williams, G.M. (1995) Glutamine synthetase and hepatocarcinogenesis. Carcinogenesis, 16, 1673-1681.
18. Maeura, Y. and Williams, G.M. (1984) Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenyl-acetamide in rats. Food Chem. Toxicol., 22, 191-198.
19. Williams, G.M. (1994) Interventive prophylaxis of liver cancer. Eur. J. Cancer Prev., 3, 89-99.