Mitochondrial tRNASer(UCN) gene is the hot spot for mutations associated with aminoglycoside-induced and non-syndromic hearing loss

Biochemical and Biophysical Research Communications

Volumn 361, Issue 1, 2007, Pages 133-139

  Jin, Longjin ^a   Yang, Aifen ^a   Zhu, Yi ^a   Zhao, Jianyue ^a   Wang, Xinjian ^b   Yang, Li ^b   Sun, Dongmei ^a   Tao, Zhihua ^a   Tsushima, Asami ^b   Wu, Guomin ^c   Xu, Limin ^c   Chen, Chongxi ^a   Yi, Boquan ^d   Cai, Jianxin ^e   Tang, Xiaowen ^a   Wang, Jindan ^a   Li, Dong ^a   Yuan, Qian ^a   Liao, Zhisu ^a   Chen, Jiafu ^a   Li, Zhiyuan ^a   Lu, Jianxin ^a   Guan, Min Xin ^a,b,f   more..

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE   (China)

^d Wenzhou Special School for Deaf Mutes   (China)

^e Ruian Special School for Deaf Mutes   (China)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Aminoglycoside ototoxicity; Chinese; Hearing loss; Mitochondrial DNA; Mutation; Penetrance; tRNASer(UCN)

Indexed keywords

AMINOGLYCOSIDE; SERINE; TRANSFER RNA; RNA; RNA, MITOCHONDRIAL; SERINE TRANSFER RNA; UNCLASSIFIED DRUG;

AIR CONDUCTION; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RECOMBINATION; GENETIC SCREENING; HEARING LOSS; HUMAN; MAJOR CLINICAL STUDY; MALE; MITOCHONDRION; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; ADOLESCENT; CHEMICALLY INDUCED DISORDER; CHILD; CHINA; GENETICS; MITOCHONDRIAL GENE; PEDIGREE; POINT MUTATION;

ADOLESCENT; AMINOGLYCOSIDES; CHILD; CHINA; FEMALE; GENES, MITOCHONDRIAL; HEARING LOSS; HEARING LOSS, BILATERAL; HUMANS; MALE; PEDIGREE; POINT MUTATION; RNA; RNA, TRANSFER, SER;

EID: 34547134236     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.06.171     Document Type: Article

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