Cosegregation of the G7444A mutation in the mitochondrial COI/tRNA Ser(UCN) genes with the 12S rRNA A1555G mutation in a chinese family with aminoglycoside-induced and nonsyndromic hearing loss

American Journal of Medical Genetics

Volumn 138 A, Issue 2, 2005, Pages 133-140

  Yuan, Huijun ^a   Qian, Yaping ^b   Xu, Yanjun ^a   Cao, Juyang ^a   Bai, Linna ^c   Shen, Weidong ^a   Ji, Fei ^a   Zhang, Xin ^a   Kang, Dongyang ^a   Mo, Jun Qin ^d   Greinwald, John H ^b,d   Han, Dongyi ^a   Zhai, Suoqiang ^a   Young, Wie Yen ^a   Guan, Min Xin ^b,d  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c Jiangxi Rehabilitation Center for Disabled Persons   (China)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

12S rRNA; Aminoglycoside ototoxicity; Chinese; COI; Haplogroup; Mitochondrial DNA mutation; Modulation; Non syndromic hearing loss; Penetrance; Precursor; Processing; tRNASer(UCN)

Indexed keywords

AMINO ACID DERIVATIVE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; LYSYLGLYCYLLYSINE; MITOCHONDRIAL DNA; RIBOSOME RNA; RNA 12S; TRANSFER RNA; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; AUDIOMETRY; CARBOXY TERMINAL SEQUENCE; CHILD; CHINESE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; FEMALE; GENE MUTATION; GENE SEGREGATION; GENETIC SUSCEPTIBILITY; HEARING LOSS; HUMAN; HUMAN CELL; MALE; NUCLEOTIDE SEQUENCE; OTOTOXICITY; PEDIGREE; PERCEPTION DEAFNESS; PHENOTYPE; PRIORITY JOURNAL; RNA GENE; RNA PROCESSING; SEQUENCE ANALYSIS; STOP CODON;

ADOLESCENT; ADULT; AGED; AMINOGLYCOSIDES; BASE SEQUENCE; CHILD; CHINA; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; FAMILY HEALTH; FEMALE; HEARING LOSS; HUMANS; INHERITANCE PATTERNS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEDIGREE; POINT MUTATION; RNA, RIBOSOMAL; RNA, TRANSFER, SER;

EID: 25144501268     PISSN: 15524825     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.a.30952     Document Type: Article

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