Presence of glutamine:fructose-6-phosphate amidotransferase for glucosamine-6-phosphate synthesis in endothelial cells: Effects of hyperglycaemia and glutamine

Diabetologia

Volumn 44, Issue 2, 2001, Pages 196-202

  Wu, G ^a   Haynes, T E ^a   Yan, W ^a   Meininger, C J ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Cardiovascular Research Institute   (United States)

Author keywords

Endothelial cells; Glucosamine 6 phosphate; Glutamine; Hyperglycaemia

Indexed keywords

GLUCOSAMINE; GLUCOSAMINE 6 PHOSPHATE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; HEXOSAMINE; NITRIC OXIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ANIMAL CELL; ARTICLE; BLOOD FLOW; DIABETES MELLITUS; ENDOTHELIUM CELL; ENZYME ACTIVITY; GLUCONEOGENESIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR DISEASE;

ANIMALS; AORTA; CATTLE; CELLS, CULTURED; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; GLUCOSAMINE; GLUCOSE-6-PHOSPHATE; GLUTAMINE; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); HUMANS; HYPERGLYCEMIA; INSULIN; MICROCIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION; UMBILICAL VEINS; URIDINE DIPHOSPHATE N-ACETYLGALACTOSAMINE; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE; VENULES;

EID: 0035131450     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051599     Document Type: Article

References (34)

1. Enzymes utilizing glutamine as an amide donor
2. Distribution of glutamine hexosephosphate aminotransferase in rat tissues: Changes with state of differentiation
3. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system
4. Glucose and glucosamine regulates growth factor gene expression in vascular smooth muscle cells
5. Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues
6. High glucose-induced transforming growth factor β1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
7. Increased hexosamine availability similarly impairs the action of insulin and IGF-I on glucose disposal
8. Increased activity of the hexosamine synthesis pathway in muscles of insulin-resistant ob/ob mice
9. Glucosamine induces insulin resistance in vivo by affecting GLUT4 translocation in skeletal muscle
10. Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance
11. Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver
12. Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles
13. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycaemic conscious rats
14. Glucosamine infusion in rats mimics the β-cell dysfunction of non-insulin-dependent diabetes mellitus
15. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early post-receptor insulin signaling events in skeletal muscle
16. Induction of insulin-resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin
17. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor
18. L-Glutamine inhibits nitric oxide synthesis in bovine venular endothelial cells
19. Endothelial dysfunction in diabetes mellitus
20. Effects of nitric oxide-modulating amino acids on coronary vessels: Relevance to sepsis
21. Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide (NO) synthesis
22. Regulation of L-arginine synthesis from L-citrulline by L-glutamine in endothelial cells
23. Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat
24. Separation and analysis of 4′-epimeric UDP-sugars by borate high-performance liquid chromatography
25. The spontaneously diabetic Wistar rat
26. UDP-Nacetylglucosamine transferase and glutamine:fructose 6-phosphate aminotransferase activities in insulin-sensitive tissues
27. Glutamine metabolism in endothelial cells: Ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase
28. Insulin stimulates glycolysis and pentose cycle activity in bovine microvascular endothelial cells
29. Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM
30. cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse
31. Vascular effects of acute hyperglycaemia in humans are reversed by L-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia
32. Restoration of nitric oxide production by aldose reductase inhibitor in human endothelial cells cultured in high-glucose medium
33. Nitric oxide as a signaling molecule in the vascular system: An overview