Disruption of hedgehog signalling in ApoE-/- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages

Journal of Pathology

Volumn 212, Issue 4, 2007, Pages 420-428

  Beckers, L ^a   Heeneman, S ^a   Wang, L ^b   Burkly, L C ^c   Rousch, M M J ^a   Davidson, N O ^d   Gijbels, M J J ^a   de Winther, M P J ^a   Daemen, M J A P ^a   Lutgens, E ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b ABBOTT LABORATORIES   (United States)

^c BIOGEN   (United States)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

Atherosclerosis; Hedgehog; Lipids

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; CHOLESTEROL ESTER; IMMUNOGLOBULIN G; LIPID; MONOCLONAL ANTIBODY; OXIDIZED LOW DENSITY LIPOPROTEIN; SCAVENGER RECEPTOR; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FLOW CYTOMETRY; FOAM CELL; HISTOPATHOLOGY; IMMUNOCHEMISTRY; LIPID BLOOD LEVEL; LIPID TRANSPORT; MACROPHAGE; MALE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

AGED; AGED, 80 AND OVER; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BODY WEIGHT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HEDGEHOG PROTEINS; HUMANS; LIPIDS; LIPOPROTEINS, LDL; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

EID: 34547127386     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2193     Document Type: Article

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