The expression and effects of hepcidin in the mouse brain and its modulating effects on ferroportin 1 and divalent metal transporter 1

Acta Anatomica Sinica

Volumn 38, Issue 3, 2007, Pages 265-270

  Fu, Li Juan ^a   Duan, Xiang Lin ^a   Yu, Peng ^a   Qian, Zhong Ming ^a,b   Chang, Yan Zhong ^a  

^a HEBEI NORMAL UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Brain iron metabolism; Divalent metal transporter 1; Ferroportin1; Hepcidin; Mouse; RT PCR

Indexed keywords

FERROPORTIN 1; HEPCIDIN; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; BRAIN VENTRICLE; CHOROID PLEXUS; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IRON METABOLISM; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; TISSUE DISTRIBUTION;

EID: 34547104605     PISSN: 05291356     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Meneghini R. Iron homeostasis, oxidative stress, and DNA damage [J]. Free Radic Biol Med, 1997, 23(5):783-792.
2. Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity [J]. FEBS Lett, 2000, 480(2-3): 147-150.
3. Park CH, Valore EV, Waring AJ, et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver [J]. J. Biol Chem, 2001, 276(11): 7806-7810.
4. Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2) knockout mice [J]. Proc Natl Acad Sci USA, 2001, 98 (15):8780-8785.
5. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic, mice expressing liver hepcidin [J]. Proc Natl Acad Sci USA, 2002, 99(7):4596-4601.
6. Masaki T, Yoshimatsu H, Chiba S, et al. Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice[J]. Diabetes, 2001, 50(2):376-384.
7. Zechel S, Huber-Wittmer K, Oliver von Bohlen und Halbach. Distribution of the iron-regulating protein hepcidin in the murine central nervous system[J]. J Neurosci Res, 2006, 84(7):790-800.
8. Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter [J]. Nature, 1997, 388 (6641):482-488.
9. Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter[J]. Nature, 2000, 403(6771):776-781.
10. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates celluar iron efflux by binding to ferroportin and inducing its internalization [J]. Science, 2004, 306(5704):2090-2093.
11. Ke Y, Chang YZ, Doan XL, et al. Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain [J]. Neurobiol Aging, 2005, 26 (5): 739-748.
12. Jiang DH, Ke Y, Chang YZ, et al. Distribution of ferroportin1 protein in different regions of developing rat brain[J]. Dev Neurosci, 2002, 24 (2-3):94-98.
13. Chang YZ, Qian ZM, Wang K, et al. Effects of development and iron status on ceruloplasmin expression in rat brain [J]. J Cell Physiol, 2005, 204(2):623-631.