Homocysteine, cystathionine, methylmalonic acid and B-vitamins in patients with renal disease

Clinical Chemistry and Laboratory Medicine

Volumn 39, Issue 8, 2001, Pages 739-746

  Herrmann, W ^a   Schorr, H ^a   Geisel, J ^a   Riegel, W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

B vitamins; Cystathionine; Folate; Homocysteine; Kidney; Methylmalonic acid

Indexed keywords

CYANOCOBALAMIN; CYSTATHIONINE; FOLIC ACID; HOMOCYSTEINE; METHIONINE; METHYLMALONIC ACID; PYRIDOXINE; VITAMIN B GROUP;

ADULT; AGED; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CHEMOLUMINESCENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FEMALE; GAS CHROMATOGRAPHY; HEMODIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLITE; METHYLATION; PRIORITY JOURNAL; REGRESSION ANALYSIS; VITAMIN BLOOD LEVEL; VITAMIN DEFICIENCY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTATHIONINE; FEMALE; HOMOCYSTEINE; HUMANS; IMMUNOASSAY; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; METHYLMALONIC ACID; MIDDLE AGED; RENAL DIALYSIS; VITAMIN B COMPLEX;

EID: 0034833992     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2001.123     Document Type: Article

References (48)

1. Hyperhomocysteinaemia as a cardiovascular risk factor: An update
2. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease
3. Total homocysteine in plasma or serum: Methods and clinical applications
4. Homocysteine
5. Homocysteine metabolism
6. The metabolism of homocysteine: Pathways and regulation
7. Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia
8. Hyperhomocysteinemia as a possible role for atherosclerosis in CAPD patients
9. Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients
10. Hyperhomocysteinemia in cyclosporine-treated renal transplant recipients
11. Hyperhomocysteinaemia: A significant risk factor for cardiovascular disease in renal transplant recipients
12. The role of homocysteine in end stage renal disease
13. Treatment of mild hyperhomocysteinemia in renal transplant recipients versus hemodialysis patients
14. Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes
15. Homocysteine metabolism in renal failure
16. Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure
17. The effect of reduced glomerular filtration rate on plasma total homocysteine concentration
18. Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency
19. Hyperhomocysteinaemia: A role in the accelerated atherogenesis of chronic renal failure?
20. Folic acid treatment of hyperhomocysteinemia in peritoneal dialysis patients: No change in endothelial function after long-term therapy
21. Homocysteine and methionine metabolism in ESRD: A stable isotope study
22. The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients
23. Folic acid treatment of hyperhomocysteinemia in dialysis patients
24. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients
25. Supplementation with vitamin B12 decreases homocysteine and methylmalonic acid but also serum folate in patients with end-stage renal disease
26. Plasma folate conjugase activities and folate concentrations in patients receiving hemodialysis
27. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies
28. The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency
29. Screening elderly populations for cobalamin (vitamin B12) deficiency using the urinary methylmalonic acid assay by gas chromatography mass spectrometry
30. Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency
31. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
32. Stability of pyridoxal-5-phosphate semicarbazone: Applications in plasma vitamin B6 analysis and population surveys of vitamin B6 nutritional status
33. Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects
34. Serum cystatin C as a determinant of fasting total homocysteine levels in renal transplant recipients with a normal serum creatinine 5
35. Evidence of altered homocysteine metabolism in chronic renal failure
36. Methylmalonic acid in renal insufficiency: Evidence of accumulation and implications for diagnosis of cobalamin deficiency
37. Studies on methylmalonic acid in humans. I. Concentrations in serum and urinary excretion in normal subjects after feeding and during fasting, and after loading with protein, fat, sugar, isoleucine, and valine
38. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis
39. Laboratory diagnosis of vitamin B12 and folate deficiency: A guide for the primary care physician
40. Relationship between methylmalonic acid and cobalamin in uremia
41. Low holotranscobalamin II is the earliest serum marker for subnormal vitamin B12 (cobalamin) absorption in patients with AIDS
42. Cobalamin and folate evaluation: Measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate
43. Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations
44. Accumulation of homocyst(e)ine in vitamin B-6 deficiency: A model for the study of cystathionine beta-synthase deficiency
45. The effect of a subnormal vitamin B-6 status on homocysteine metabolism
46. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration
47. Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase?
48. The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine