Lipin1 regulation by estrogen in uterus and liver: Implications for diabetes and fertility

Endocrinology

Volumn 148, Issue 8, 2007, Pages 3685-3693

  Gowri, P Mangala ^a   Sengupta, Surojeet ^a   Bertera, Suzanne ^b   Katzenellenbogen, Benita S ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; HUMAN INSULIN; INSULIN; LIPIN1; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ESTROGEN BLOOD LEVEL; ESTRUS CYCLE; FEMALE; FEMALE FERTILITY; IMMUNOHISTOCHEMISTRY; INSULIN TREATMENT; LIVER; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; UTERUS;

ANIMALS; DIABETES MELLITUS, TYPE 1; DOWN-REGULATION; EPITHELIUM; ESTRADIOL; ESTROUS CYCLE; FEMALE; FERTILITY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INFERTILITY, FEMALE; LIVER; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; NUCLEAR PROTEINS; UTERUS;

EID: 34547099571     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1728     Document Type: Article

References (52)

1. Hall JM, Couse JF, Korach KS 2001 The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276:36869-36872
2. Korach KS, Emmen JM, Walker VR, Hewitt SC, Yates M, Hall JM, Swope DL, Harrell JC, Couse JF 2003 Update on animal models developed for analyses of estrogen receptor biological activity. J Steroid Biochem Mol Biol 86:387-391
3. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JA 2001 Mechanisms of estrogen action. Physiol Rev 81:1535-1565
4. Gonzalez C, Alonso A, Grueso NA, Esteban MM, Fernandez S, Patterson AM 2002 Effect of treatment with different doses of 17-β-estradiol on the insulin receptor. Life Sci 70:1621-1630
5. Le May C, Chu K, Hu M, Ortega CS, Simpson ER, Korach KS, Tsai MJ, Mauvais-Jarvis F 2006 Estrogens protect pancreatic β-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci USA 103:9232-9237
6. Livingstone C, Collison M 2002 Sex steroids and insulin resistance. Clin Sci (Lond) 102:151-166
7. Cooke PS, Naaz A 2004 Role of estrogens in adipocyte development and function. Exp Biol Med (Maywood) 229:1127-1135
8. Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS 2000 Increased adipose tissue in male and female estrogen receptor-α knockout mice. Proc Natl Acad Sci USA 97:12729-12734
9. Jones ME, Thorburn AW, Britt KL, Hewitt KN, Wreford NG, Proietto J, Oz OK, Leury BJ, Robertson KM, Yao S, Simpson ER 2000 Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci USA 97:12735-12740
10. Misso ML, Murata Y, Boon WC, Jones ME, Britt KL, Simpson ER 2003 Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse. Endocrinology 144:1474-1480
11. Arrais RF, Dib SA 2006 The hypothalamus-pituitary-ovary axis and type 1 diabetes mellitus: a mini review. Hum Reprod 21:327-337
12. Otani H, Tanaka O, Tatewaki R, Naora H, Yoneyama T 1991 Diabetic environment and genetic predisposition as causes of congenital malformations in NOD mouse embryos. Diabetes 40:1245-1250
13. Reue K, Doolittle MH 1996 Naturally occurring mutations in mice affecting lipid transport and metabolism. J Lipid Res 37:1387-1405
14. Durant S, Christeff N, Coulaud J, Nunez EA, Dardenne M, Homo-Delarche F 1998 Basal concentrations of various steroids in the nonobese diabetic (NOD) mouse and effect of immobilization stress. Autoimmunity 28:249-258
15. Bao M, Yang Y, Jun HS, Yoon JW 2002 Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 168:5369-5375
16. Tatewaki R, Otani H, Tanaka O, Kitada J 1989 A morphological study on the reproductive organs as a possible cause of developmental abnormalities in diabetic NOD mice. Histol Histopathol 4:343-358
17. Peterfy M, Phan J, Xu P, Reue K 2001 Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27:121-124
18. Phan J, Reue K 2005 Lipin, a lipodystrophy and obesity gene. Cell Metab 1:73-83
19. Santos-Rosa H, Leung J, Grimsey N, Peak-Chew S, Siniossoglou S 2005 The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. EMBO J 24:1931-1941
20. 2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 281: 9210-9218
21. Phan J, Peterfy M, Reue K 2004 Lipin expression preceding peroxisome proliferator-activated receptor-γ is critical for adipogenesis in vivo and in vitro. J Biol Chem 279:29558-29564
22. Verheijen MH, Chrast R, Burrola P, Lemke G 2003 Local regulation of fat metabolism in peripheral nerves. Genes Dev 17:2450-2464
23. Huffman TA, Mothe-Satney I, Lawrence Jr JC 2002 Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc Natl Acad Sci USA 99:1047-1052
24. Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A, Lawrence Jr JC 2007 Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J Biol Chem 282: 277-286
25. Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence Jr JC, Kelly DP 2006 Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway. Cell Metab 4:199-210
26. Shultz LD, Lang PA, Christianson SW, Gott B, Lyons B, Umeda S, Leiter E, Hesselton R, Wagar EJ, Leif JH, Kollet O, Lapidot T, Greiner DL 2000 NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells. J Immunol 164:2496-2507
27. Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM 2006 Nuclear receptor expression links the circadian clock to metabolism. Cell 126:801-810
28. Peterfy M, Phan J, Reue K 2005 Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem 280:32883-32889
29. Levene H 1960 Robust tests for the equality of variance. In: Olkin I, ed. Contributions to probability and statistics. Palo Alto, CA: Stanford University Press; 278-292
30. Dunnett CW 1955 A multiple comparisons procedure for comparing several treatments with a control. J Am Stat Assoc 50:1096-1121
31. Holland BS, Copenhaver MD 1987 An improved sequentially rejective Bonferroni test procedure. Biometrics 43:417-424
32. Sundstrom SA, Komm BS, Ponde-de-Leon H, Yi Z, Teuscher C, Lyttle CR 1989 Estrogen regulation of tissue-specific expression of complement. J Biol Chem 264:16941-16947
33. Nardulli AM, Katzenellenbogen BS 1986 Dynamics of estrogen receptor turnover in uterine cells in vitro and in uteri in vivo. Endocrinology 119:2038-2046
34. Boverhof DR, Fertuck KC, Burgoon LD, Eckel JE, Gennings C, Zacharewski TR 2004 Temporal- and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol. Carcinogenesis 25:1277-1291
35. Kneifel MA, Katzenellenbogen BS 1981 Comparative effects of estrogen and antiestrogen on plasma renin substrate levels and hepatic estrogen receptors in the rat. Endocrinology 108:545-552
36. Altomonte J, Cong L, Harbaran S, Richter A, Xu J, Meseck M, Dong HH 2004 Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J Clin Invest 114:1493-1503
37. Bryzgalova G, Gao H, Ahren B, Zierath JR, Galuska D, Steiler TL, Dahlman-Wright K, Nilsson S, Gustafsson JA, Efendic S, Khan A 2006 Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver. Diabetologia 49:588-597
38. Spooner PM, Gorski J 1972 Early estrogen effects on lipid metabolism in rat uterus. Endocrinology 91:1273-1283
39. Dang ZC, van Bezooijen RL, Karperien M, Papapoulos SE, Lowik CW 2002 Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res 17:394-405
40. Stace CL, Ktistakis NT 2006 Phosphatidic acid- and phosphatidylserine-binding proteins. Biochim Biophys Acta 1761:913-926
41. Nanjundan M, Possmayer F 2003 Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. Am J Physiol Lung Cell Mol Physiol 284:L1-L23
42. Coleman RA, Lewin TM, Muoio DM 2000 Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. Annu Rev Nutr 20:77-103
43. Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J 2001 Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294:1942-1945
44. Boulay A, Rudloff J, Ye J, Zumstein-Mecker S, O'Reilly T, Evans DB, Chen S, Lane HA 2005 Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res 11:5319-5328
45. Andresen BT, Rizzo MA, Shome K, Romero G 2002 The role of phosphatidic acid in the regulation of the Ras/MEK/Erk signaling cascade. FEBS Lett 531:65-68
46. Ghosh S, Strum JC, Sciorra VA, Daniel L, Bell RM 1996 Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells. J Biol Chem 271: 8472-8480
47. Jose Lopez-Andreo M, Gomez-Fernandez JC, Corbalan-Garcia S 2003 The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cε to the plasma membrane in RBL-2H3 cells. Mol Biol Cell 14:4885-4895
48. Rizzo MA, Shome K, Watkins SC, Romero G 2000 The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras. J Biol Chem 275:23911-23918
49. Ignar-Trowbridge DM, Hughes AR, Putney Jr JW, McLachlan JA, Korach KS 1991 Diethylstilbestrol stimulates persistent phosphatidylinositol lipid turnover by an estrogen receptor-mediated mechanism in immature mouse uterus. Endocrinology 129:2423-2430
50. Jiang Y, Lu Z, Zang Q, Foster DA 1996 Regulation of phosphatidic acid phosphohydrolase by epidermal growth factor. Reduced association with the EGF receptor followed by increased association with protein kinase Cε. J Biol Chem 271:29529-29532
51. Brachat A, Pierrat B, Xynos A, Brecht K, Simonen M, Brungger A, Heim J 2002 Amicroarray-based, integrated approach to identify novel regulators of cancer drug response and apoptosis. Oncogene 21:8361-8371
52. Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2006 Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126:789-799