Expression profile of proteins involved in scar formation in the healing process of full-thickness excisional wounds in the porcine model

Wound Repair and Regeneration

Volumn 15, Issue 4, 2007, Pages 482-490

  Ulrich, Magda M W ^a,b   Verkerk, Michelle ^a   Reijnen, Linda ^a   Vlig, Marcel ^a   Van Den Bogaerdt, Antoon J ^a,c   Middelkoop, Esther ^a,b  

^a ASSOCIATION OF DUTCH BURN CENTRES   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RED CROSS HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; MATRIX METALLOPROTEINASE; MESSENGER RNA; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR FORMATION; SWINE; WOUND;

ANIMALS; CICATRIX; DISEASE MODELS, ANIMAL; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASES; PROCOLLAGEN-LYSINE, 2-OXOGLUTARATE 5-DIOXYGENASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 34447628355     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2007.00255.x     Document Type: Article

References (31)

1. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. Pathology 2003 200 : 500 3.
2. Eyre DR, Paz MA, Gallop PM. Cross-linking in collagen and elastin. Annu Rev Biochem 1984 53 : 717 48.
3. Ricard-Blum S, Esterre P, Grimaud JA. Collagen cross-linking by pyridinoline occurs in non-reversible skin fibrosis. Cell Mol Biol (Noisy-le-grand) 1993 39 : 723 7.
4. Uzawa K, Marshall MK, Katz EP, Tanzawa H, Yeowell HN, Yamauchi M. Altered posttranslational modifications of collagen in keloid. Biochem Biophys Res Commun 1998 249 : 652 5.
5. Brinckmann J, Neess CM, Gaber Y, Sobhi H, Notbohm H, Hunzelmann N, Fietzek PP, Muller PK, Risteli J, Gebker R, Scharffetter-Kochanek K. Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma. J Invest Dermatol 2001 117 : 269 73.
6. Brinckmann J, Notbohm H, Tronnier M, Acil Y, Fietzek PP, Schmeller W, Muller PK, Batge B. Overhydroxylation of lysyl residues is the initial step for altered collagen cross-links and fibril architecture in fibrotic skin. J Invest Dermatol 1999 113 : 617 21.
7. Istok R, Bely M, Stancikova M, Rovensky J. Evidence for increased pyridinoline concentration in fibrotic tissues in diffuse systemic sclerosis. Clin Exp Dermatol 2001 26 : 545 7.
8. Moriguchi T, Fujimoto D. Crosslink of collagen in hypertrophic scar. J Invest Dermatol 1979 72 : 143 5.
9. Van der Slot AJ, Zuurmond AM, Bardoel AF, Wijmenga C, Pruijs HE, Sillence DO, Brinckmann J, Abraham DJ, Black CM, Verzijl N, DeGroot J, Hanemaaijer R, Tekopple JM, Huizinga TW, Bank RA. Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. J Biol Chem 2003 278 : 40967 72.
10. Mercer DK, Nicol PF, Kimbembe C, Robins SP. Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms. Biochem Biophys Res Commun 2003 307 : 803 9.
11. van der Slot AJ, van Dura EA, de Wit EC, DeGroot J, Huizinga TW, Bank RA, Zuurmond AM. Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels. Biochim Biophys Acta 2005 1741 : 95 102.
12. van der Slot AJ, Zuurmond AM, van den Bogaerdt AJ, Ulrich MM, Middelkoop E, Boers W, Karel Ronday H, DeGroot J, Huizinga TW, Bank RA. Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon. Matrix Biol 2004 23 : 251 7.
13. Shah M, Foreman D, Ferguson M. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995 108 : 985 1002.
14. van den Bogaerdt AJ, van der Slot AJ, Ulrich MMW, Zuurmond AM, Bank RA, Middelkoop E. Altered collagen cross-linking by subcutaneous fat fibroblasts during wound healing. Wound Rep Reg 2003 11 : A28.
15. Middelkoop E, van den Bogaerdt AJ, Lamme EN, Hoekstra MJ, Brandsma K, Ulrich MM. Porcine wound models for skin substitution and burn treatment. Biomaterials 2004 25 : 1559 67.
16. Lamme EN, de Vries HJ, van Veen H, Gabbiani G, Westerhof W, Middelkoop E. Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs. J Histochem Cytochem 1996 44 : 1311 22.
17. Bank RA, Beekman B, Verzijl N, de Roos JA, Sakkee AN, TeKoppele JM. Sensitive fluorimetric quantitation of pyridinium and pentosidine crosslinks in biological samples in a single high-performance liquid chromatographic run. J Chromatogr B Biomed Sci Appl 1997 703 : 37 44.
18. Reiser K, McCormick RJ, Rucker RB. Enzymatic and nonenzymatic cross-linking of collagen and elastin. Faseb J 1992 6 : 2439 49.
19. Kagan HM. Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis. Acta Trop 2000 77 : 147 52.
20. Pornprasertsuk S, Duarte WR, Mochida Y, Yamauchi M. Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization. J Bone Miner Res 2005 20 : 81 7.
21. van der Slot-Verhoeven AJ, van Dura EA, Attema J, Blauw B, DeGroot J, Huizinga TW, Zuurmond AM, Bank RA. The type of collagen cross-link determines the reversibility of experimental skin fibrosis. Biochim Biophys Acta 2005 1740 : 60 7.
22. Mohan R, Chintala SK, Jung JC, Villar WV, McCabe F, Russo LA, Lee Y, McCarthy BE, Wollenberg KR, Jester JV, Wang M, Welgus HG, Shipley JM, Senior RM, Fini ME. Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem 2002 277 : 2065 72.
23. Salo T, Makela M, Kylmaniemi M, Autio-Harmainen H, Larjava H. Expression of matrix metalloproteinase-2 and -9 during early human wound healing. Lab Invest 1994 70 : 176 82.
24. Kinoshita T, Sato H, Okada A, Ohuchi E, Imai K, Okada Y, Seiki M. TIMP-2 promotes activation of progelatinase A by membrane-type 1 matrix metalloproteinase immobilized on agarose beads. J Biol Chem 1998 273 : 16098 103.
25. Soo C, Shaw WW, Zhang X, Longaker MT, Howard EW, Ting K. Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair. Plast Reconstr Surg 2000 105 : 638 47.
26. Wang JF, Olson ME, Reno CR, Kulyk W, Wright JB, Hart DA. Molecular and cell biology of skin wound healing in a pig model. Connect Tissue Res 2000 41 : 195 211.
27. O'Kane S, Ferguson MW. Transforming growth factor beta s and wound healing. Int J Biochem Cell Biol 1997 29 : 63 78.
28. Frank S, Madlener M, Werner S. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem 1996 271 : 10188 93.
29. Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Am J Pathol 2000 157 : 423 33.
30. Levine JH, Moses HL, Gold LI, Nanney LB. Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair. Am J Pathol 1993 143 : 368 80.
31. van den Bogaerdt AJ, van Zuijlen PP, van Galen M, Lamme EN, Middelkoop E. The suitability of cells from different tissues for use in tissue-engineered skin substitutes. Arch Dermatol Res 2002 294 : 135 42.