Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms

Biochemical and Biophysical Research Communications

Volumn 307, Issue 4, 2003, Pages 803-809

  Mercer, Derry K ^a   Nicol, Phyllis F ^a   Kimbembe, Cisca ^a   Robins, Simon P ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Collagen biosynthesis; Hydroxylysine; Lysine; Lysyl hydroxylase; Procollagen lysine 2 oxoglutarate 5 dioxygenase; Telopeptide

Indexed keywords

COLLAGEN; PHENAZOPYRIDINE; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE;

ANIMAL CELL; ARTICLE; CELL TYPE; CHO CELL; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVITY; ENZYME SYNTHESIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; TISSUE DISTRIBUTION; TISSUE TYPES;

EUKARYOTA;

EID: 0038106229     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01262-2     Document Type: Article

References (33)

1. Robins S.P. Fibrillogenesis and maturation of collagens. Seibel M.J., Robins S.P., Bilezikian J.P. Dynamics of Bone and Cartilage Metabolism. 1999;31-42 Academic Press, London.
2. Vogel W., Gish G.D., Alves F., Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol. Cell. 1:1997;13-23.
3. Hautala T., Byers M.G., Eddy R.L., Shows T.B., Kivirikko K.I., Myllyla R. Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3-p36.2. Genomics. 13:1992;62-69.
4. Szpirer C., Szpirer J., Riviere M., Vanvooren P., Valtavaara M., Myllyla R. Localization of the gene encoding a novel isoform of lysyl hydroxylase. Mamm. Genome. 8:1997;707-708.
5. Passoja K., Rautavuoma K., Ala-Kokko L., Kosonen T., Kivirikko K.I. Cloning and characterization of a third human lysyl hydroxylase isoform. Proc. Natl. Acad. Sci. USA. 95:1998;10482-10486.
6. Ruotsalainen H., Sipila L., Kerkela E., Pospiech H., Myllyla R. Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse. Matrix Biol. 18:1999;325-329.
7. Sipila L., Szatanik M., Vainionpaa H., Ruotsalainen H., Myllyla R., Guenet J.L. The genes encoding mouse lysyl hydroxylase isoforms map to chromosomes 4, 5, and 9. Mamm. Genome. 11:2000;1132-1134.
8. Yeowell H.N., Walker L.C. Tissue specificity of a new splice form of the human lysyl hydroxylase 2 gene. Matrix Biol. 18:1999;179-187.
9. Ruotsalainen H., Vanhatupa S., Tampio M., Sipila L., Valtavaara M., Myllyla R. Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl hydroxylase 3/collagen glucosyltransferase. Matrix Biol. 20:2001;137-146.
10. Armstrong L.C., Last J.A. Rat lysyl hydroxylase: molecular cloning, mRNA distribution and expression in a baculovirus system. Biochim. Biophys. Acta. 1264:1995;93-102.
11. Myllyla R., Pihlajaniemi T., Pajunen L., Turpeenniemi-Hujanen T., Kivirikko K.I. Molecular cloning of chick lysyl hydroxylase. Little homology in primary structure to the two types of subunit of prolyl 4-hydroxylase. J. Biol. Chem. 266:1991;2805-2810.
12. Norman K.R., Moerman D.G. The let-268 locus of Caenorhabditis elegans encodes a procollagen lysyl hydroxylase that is essential for type IV collagen secretion. Dev. Biol. 227:2000;690-705.
13. Hyland J., Ala-Kokko L., Royce P., Steinmann B., Kivirikko K.I., Myllyla R. A homozygous stop codon in the lysyl hydroxylase gene in two siblings with Ehlers-Danlos syndrome type VI. Nat. Genet. 2:1992;228-231.
14. Yeowell H.N., Walker L.C. Ehlers-Danlos syndrome type VI results from a nonsense mutation and a splice site-mediated exon-skipping mutation in the lysyl hydroxylase gene. Proc. Assoc. Am. Phys. 109:1997;383-396.
15. Eyre D., Shao P., Weis M.A., Steinmann B. The kyphoscoliotic type of Ehlers-Danlos syndrome (type VI): differential effects on the hydroxylation of lysine in collagens I and II revealed by analysis of cross-linked telopeptides from urine. Mol. Genet. Metab. 76:2002;211-216.
16. Uzawa K., Grzesik W.J., Nishiura T., Kuznetsov S.A., Robey P.G., Brenner D.A., Yamauchi M. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. J. Bone Miner. Res. 14:1999;1272-1280.
17. Royce P.M., Barnes M.J. Failure of highly purified lysyl hydroxylase to hydroxylate lysyl residues in the non-helical regions of collagen. Biochem. J. 230:1985;475-480.
18. Bank R.A., Robins S.P., Wijmenga C., Breslau-Siderius L.J., Bardoel A.F., van der Sluijs H.A., Pruijs H.E., TeKoppele J.M. Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: for a bone-specific telopeptide lysyl hydroxylase on chromosome 17. Proc. Natl. Acad. Sci. USA. 96:1999;1054-1058.
19. Heikkinen J., Risteli M., Wang C., Latvala J., Rossi M., Valtavaara M., Myllyla R. Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity. J. Biol. Chem. 275:2000;36158-36163.
20. Wang C., Luosujarvi H., Heikkinen J., Risteli M., Uitto L., Myllyla R. The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro. Matrix Biol. 21:2002;559-566.
21. Rautavuoma K., Takaluoma K., Passoja K., Pirskanen A., Kvist A.P., Kivirikko K.I., Myllyharju J. Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity. J. Biol. Chem. 277:2002;23084-23091.
22. Iredale J.P., Benyon R.C., Pickering J., McCullen M., Northrop M., Pawley S., Hovell C., Arthur M.J. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J. Clin. Invest. 102:1998;538-549.
23. Pratt D.A., Daniloff Y., Duncan A., Robins S.P. Automated analysis of the pyridinium crosslinks of collagen in tissue and urine using solid-phase extraction and reversed-phase high-performance liquid chromatography. Anal. Biochem. 207:1992;168-175.
24. Firschein H.E., Shill J.P. The determination of total hydroxyproline in urine and bone extracts. Anal. Biochem. 14:1966;296-304.
25. Nutt E., Dunwiddie C., Jacobs J.W., Simpson E. Identification of novel proteins synthesized in bone cells by antibody screening of a cDNA expression library. Biochem. Biophys. Res. Commun. 151:1988;382-387.
26. Yeowell H.N., Allen J.D., Walker L.C., Overstreet M.A., Murad S., Thai S.F. Deletion of cysteine 369 in lysyl hydroxylase1 eliminates enzyme activity and causes Ehlers-Danlos syndrome type VI. Matrix Biol. 19:2000;37-46.
27. Pirskanen A., Kaimio A.M., Myllyla R., Kivirikko K.I. Site-directed mutagenesis of human lysyl hydroxylase expressed in insect cells. Identification of histidine residues and an aspartic acid residue critical for catalytic activity. J. Biol. Chem. 271:1996;9398-9402.
28. Wang C., Risteli M., Heikkinen J., Hussa A.K., Uitto L., Myllyla R. Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3). J. Biol. Chem. 277:2002;18568-18573.
29. Reeves H.L., Friedman S.L. Activation of hepatic stellate cells - a key issue in liver fibrosis. Front. Biosci. 7:2002;808-826.
30. Krol B.J., Murad S., Walker L.C., Marshall M.K., Clark W.L., Pinnell S.R., Yeowell H.N. The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system. J. Invest. Dermatol. 106:1996;11-16.
31. Kivirikko K.I., Pihlajaniemi T. Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases. Adv. Enzymol. Relat. Areas Mol. Biol. 72:1998;325-398.
32. Franceschi R.T., Iyer B.S., Cui Y. Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J. Bone Miner. Res. 9:1994;843-854.
33. Yeowell H.N., Walker L.C., Marshall M.K., Murad S., Pinnell S.R. The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI. Arch. Biochem. Biophys. 321:1995;510-516.