Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine

Journal of Neuroimmunology

Volumn 97, Issue 1-2, 1999, Pages 16-24

  Saadé, Nayef E ^a   Lawand, Halima F ^a   Safieh Garabedian, Bared ^a   Kanaan, Salim A ^a   Atweh, Samir F ^a   Jabbur, Suhayl J ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

c Fos protein; Cyclooxygenase; Hyperalgesia; Meloxicam; Morphine; Thymulin

Indexed keywords

MELOXICAM; MORPHINE; THYMULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; HYPERALGESIA; IMMUNOREACTIVITY; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD NERVE CELL;

ANIMALS; ANTIBODIES; CYCLOOXYGENASE INHIBITORS; HEAT; HYPERALGESIA; MORPHINE; NARCOTICS; PERIPHERAL NERVES; PHYSICAL STIMULATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; THIAZINES; THIAZOLES; THYMIC FACTOR, CIRCULATING;

EID: 0032938179     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00031-4     Document Type: Article

References (35)

1. Abbadie C., Besson J.-M. C-fos expression in rat lumbar spinal cord during the development of adjuvant-induced arthritis. Neuroscience. 48:1992;985-993.
2. Abbadie C., Besson J.-M. Effects of morphine and naloxone on basal and evoked Fos-like immunoreactivity in lumbar spinal cord neurons of arthritic rats. Pain. 52:1993;29-39.
3. Bach J.F. Thymulin (FTS-Zn). Clinics in Immunol. Allergy. 3:1983;133-157.
4. Bullitt E. Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation. Brain Res. 493:1989;391-397.
5. Bullitt E. Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J. Comp. Neurol. 296:1990;517-530.
6. Dardenne M., Savino W. Control of thymus physiology by peptide hormones and neuropeptides. Immunol. Today. 15:1994;518-523.
7. Dardenne M., Charreire J., Bach J.F. Alterations in thymocyte surface markers after in vivo treatment by serum thymic factor. Cell Immunol. 39:1978;47-54.
8. Hadden J.W. Thymic endocrinology. Ann. New York Acad. Sci. 840:1998;352-358.
9. Herdegen T., Kovary K., Leah J., Bravo R. Specific temporal and spatial distribution of JUN, FOS, and KROX-24 proteins in spinal neurons following noxious transsynaptic stimulation. J. Comp. Neurol. 313:1991;178-191.
10. Honoré P., Chapman V., Buritova J., Besson J.-M. When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat? Brain Res. 705:1995;91-96.
11. Hsu S., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures. J. Histochem. Cytochem. 29:1981;577-580.
12. Hunt S.P., Pini A., Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature. 328:1987;632-634.
13. Incefy G.S., Mertelsmann R., Dardenne M., Bach J.F., Good R.A. Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor (FTS). Clin. Exp. Immunol. 40:1980;396-400.
14. Kanaan S.A., Saadé N.E., Haddad J.J., Abdelnoor A.M., Atweh S.F., Jabbur S.J., Safieh-Garabedian B. Endotoxin-induced local inflammation and hyperalgesia in rats and mice: a new model for inflammatory pain. Pain. 66:1996;373-379.
15. Kanaan S.A., Safieh-Garabedian B., Haddad J.J., Atweh S.F., Abdelnoor A.M., Jabbur S.J., Saadé N.E. Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. Pharmacology. 54:1997;285-297.
16. Kendall, M.D., Marsh, J.A., 1996. Neuroendocrine activity of the thymus. In: Marsh, J.A., Kendall, M.D. (Eds.), The Physiology of Immunity. CRC Press, Boca Raton, pp. 171-185.
17. Lima D., Avelino A., Coimbra A. Differential activation of c-fos in spinal neurones by distinct classes of noxious stimuli. NeuroReport. 4:1993;747-750.
18. Menétrey D., Gannon A., Levine J.D., Basbaum A.I. Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J. Comp. Neurol. 285:1989;177-195.
19. Morgan J.I., Curran T. Stimulus-transcription coupling in neurons: role of cellular immediate early genes. Trends Neurosci. 12:1989;459-462.
20. Munglani R., Fleming B.G., Hunt S.P. Remembrance of times past: the significance of c-fos in pain. Br. J. Anaesth. 76:1996;1-4.
21. Muziolo M., Mocchegiani E., Bressani N., Bevilacqua P., Fabris N. In vitro restoration by thymulin of NK activity of cells from old mice. Int. J. Immunopharmacol. 14:1992;57-61.
22. Noguchi K., Dubner R., Ruda M.A. Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is colocalized with Fos and Fos-related proteins. Neuroscience. 46:1992;561-570.
23. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, 2nd edition, Academic Press, New York.
24. Presley R.W., Menétrey D., Levine J.D., Basbaum A.I. Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J. Neurosci. 10:1990;323-335.
25. Saadé N.E., Abou Jaoude P.G., Saadeh F.A., Hamoui S., Safieh-Garabedian B., Kanaan S.A., Atweh S.F., Jabbur S.J. Fos-like immunoreactivity induced by intraplantar injection of endotoxin and its reduction by morphine. Brain Res. 769:1997;57-65.
26. Saadé N.E., Major S.C., Atweh S.F., Jabbur S.J., Kanaan S.A., Safieh-Garabedian B. Involvement of capsaicin sensitive primary afferents in thymulin-induced hyperalgesia. J. Neuroimmunol. 91:1998;171-179.
27. Safieh-Garabedian B., Kendall M.D., Khamashta M.A., Hughes G.R.V. Thymulin and its role in immunomodulation. J. Autoimmunity. 5:1992;547-555.
28. 2 in the hyperalgesia induced by intraplantar injections of low doses of thymulin. Brain Behav. Immun. 11:1997;185-200.
29. 2. J. Neuroimmunol. 73:1997;162-168.
30. Safieh-Garabedian B., Kanaan S.A., Jabbur S.J., Saadé N.E. Cytokine mediated or direct effects of thymulin on the nervous system as assessed by pain related behavior. Neuroimmun. Modulation. 6:1999;39-44.
31. Strassman A.M., Vos B.P., Mineta Y., Naderi S., Borsook D., Burstein R. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J. Neurophysiol. 70:1993;1811-1821.
32. Tölle T.R., Herdegen T., Schadrack J., Bravo R., Zimmermann M., Zieglgänsberger W. Application of morphine prior to noxious stimulation differentially modulates expression of Fos, Jun and Krox-24 proteins in rat spinal cord neurons. Neuroscience. 58:1994;305-321.
33. Traub R.J., Pechman P., Iadarola M.J., Gebhart G.F. Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat. Pain. 49:1992;393-403.
34. Vane, J.R., Botting, R.M., 1996. Mechanism of action of anti-inflammatory drugs. Scand. J. Rheumatol., 9-21.
35. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.