A p38 MAP kinase regulates the expression of the Aedes aegypti defensin gene in mosquito cells

Insect Molecular Biology

Volumn 16, Issue 4, 2007, Pages 389-399

  Chen Chih Wu, R ^a   Shaio, M F ^b,c   Cho, W L ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b KUANG TIEN GENERAL HOSPITAL   (Taiwan)

^c HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Defensin; MAP kinase; Mosquito immunity

Indexed keywords

DEFENSIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38;

AEDES; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; CHEMICAL STRUCTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY; PROTEIN CONFORMATION;

AEDES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CELLS, CULTURED; CLONING, MOLECULAR; DEFENSINS; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYLOGENY; PROTEIN CONFORMATION;

AEDES AEGYPTI; BACTERIA (MICROORGANISMS);

EID: 34447618286     PISSN: 09621075     EISSN: 13652583     Source Type: Journal    
DOI: 10.1111/j.1365-2583.2007.00734.x     Document Type: Article

References (46)

1. Ben-Levy, R., Hooper, S., Wilson, R., Paterson, H.F. Marshall, C.J. (1998) Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol 8 : 1049 1057.
2. Bian, G., Shin, S.W., Cheon, H.M., Kokoza, V. Raikhel, A.S. (2005) Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti. Proc Natl Acad Sci USA 102 : 13568 13573.
3. Bode, A.M. Dong, Z. (2003) Mitogen-activated protein kinase activation in UV-induced signal transduction. DOI: 10.1126/stke.2003.167.re2.
4. Breman, J.G., Egan, A. Keusch, G.T. (2001) The intolerable burden of malaria: a new look at the numbers. Am J Trop Med Hyg 64 : iv vii.
5. Chang, C.I., Xu, B.E., Akella, R., Cobb, M.H. Goldsmith, E.J. (2002) Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol Cell 9 : 1241 1249.
6. Chiou, J.Y., Huang, S.J., Huang, S.T. Cho, W.L. (1998) Identification of immune-related protein kinases from mosquitoes (Aedes aegypti). J Biomed Sci 5 : 120 126.
7. Cho, W.L. Raikhel, A.S. (1992) Cloning of cDNA for mosquito lysosomal aspartic protease. J Biol Chem 267 : 21823 21829.
8. Cho, W.L., Fu, Y.C., Chen, C.C. Ho, C.M. (1996) Cloning and characterization of cDNAs encoding the antibacterial peptide, defensin A, from the mosquito, Aedes aegypti. Insect Biochem Mol Biol 26 : 395 402.
9. Cho, W.L., Fu, T.F., Chiou, J.Y. Chen, C.C. (1997) Molecular characterization of a defensin gene from the mosquito, Aedes aegypti. Insect Biochem Mol Biol 27 : 351 358.
10. Christophides, G.K., Zdobnov, E., Barillas-Mury, C., Birney, E., Blandin, S., Blass, C., et al. (2002) Immunity-related genes and gene families in Anopheles gambiae. Science 298 : 159 165.
11. Christophides, G.K., Vlachou, D. Kafatos, F.C. (2004) Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae. Immunol Rev 198 : 127 148.
12. Craig, C.R., Fink, J.L., Yagi, Y., Ip, Y.T. Cagan, R.L. (2004) A Drosophila p38 orthologue is required for environmental stress responses. EMBO Rep 5 : 1058 1063.
13. Curtis, C.F. Lines, J.D. (2000) Should DDT be banned by international treaty? Parasitol Today 16 : 119 121.
14. De Gregorio, E., Spellman, P.T., Tzou, P., Rubin, G.M. Lemaitre, B. (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J 21 : 2568 2579.
15. Foukas, L.C., Katsoulas, H.L., Paraskevopoulou, N., Metheniti, A., Lambropoulou, M. Marmaras, V.J. (1998) Phagocytosis of Escherichia coli by insect hemocytes requires both activation of the Ras/mitogen-activated protein kinase signal transduction pathway for attachment and beta3 integrin for internalization. J Biol Chem 273 : 14813 14818.
16. Han, Z.S., Enslen, H., Hu, X., Meng, X., Wu, I.H., Barrett, T., et al. (1998) A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol Cell Biol 18 : 3527 3539.
17. Hanks, S.K. Hunter, T. (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9 : 576 596.
18. Hoffmann, J.A. (2003) The immune response of Drosophila. Nature 426 : 33 38.
19. Hoffmann, J.A. Reichhart, J.M. (2002) Drosophila innate immunity: an evolutionary perspective. Nat Immunol 3 : 121 126.
20. Hoffmann, J.A., Kafatos, F.C., Janeway, C.A. Ezekowitz, R.A. (1999) Phylogenetic perspectives in innate immunity. Science 284 : 1313 1318.
21. Holt, R.A., Subramanian, G.M., Halpern, A., Sutton, G.G., Charlab, R., Nusskern, D.R., et al. (2002) The genome sequence of the malaria mosquito Anopheles gambiae. Science 298 : 129 149.
22. Huang, S.J., Wu, R.C., Shaio, M.F., Wang, P.S. Cho, W.L. (2003) An immune signalling kinase AaMEK3 from mosquitoes: cDNA cloning and characterization. Insect Mol Biol 12 : 595 603.
23. Hultmark, D. (2003) Drosophila immunity: paths and patterns. Curr Opin Immunol 15 : 12 19.
24. Imler, J.L. Hoffmann, J.A. (2001) Toll receptors in innate immunity. Trends Cell Biol 11 : 304 311.
25. Karin, M., Liu, Z. Zandi, E. (1997) AP-1 function and regulation. Curr Opin Cell Biol 9 : 240 246.
26. Kyriakis, J.M. Avruch, J. (1996) Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 271 : 24313 24316.
27. Kyriakis, J.M. Avruch, J. (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81 : 807 869.
28. Lamprou, I., Tsakas, S., Theodorou, G.L., Karakantza, M., Lampropoulou, M. Marmaras, V.J. (2005) Uptake of LPS/E. coli/latex beads via distinct signalling pathways in medfly hemocytes: the role of MAP kinases activation and protein secretion. Biochim Biophys Acta 1744 : 1 10.
29. Leclerc, V. Reichhart, J.M. (2004) The immune response of Drosophila melanogaster. Immunol Rev 198 : 59 71.
30. Lycett, G.J. Kafatos, F.C. (2002) Anti-malarial mosquitoes? Nature 417 : 387 388.
31. Mavrouli, M.D., Tsakas, S., Theodorou, G.L., Lampropoulou, M. Marmaras, V.J. (2005) MAP kinases mediate phagocytosis and melanization via prophenoloxidase activation in medfly hemocytes. Biochim Biophys Acta 1744 : 145 156.
32. Meister, S., Kanzok, S.M., Zheng, X.L., Luna, C., Li, T.R., Hoa, N.T., et al. (2005) Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proc Natl Acad Sci USA 102 : 11420 11425.
33. Michel, K. Kafatos, F.C. (2005) Mosquito immunity against Plasmodium. Insect Biochem Mol Biol 35 : 677 689.
34. Mizutani, T., Kobayashi, M., Eshita, Y., Inanami, O., Yamamori, T., Goto, A., et al. (2003) Characterization of JNK-like protein derived from a mosquito cell line, C6/36. Insect Mol Biol 12 : 61 66.
35. Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J. Davis, R.J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270 : 7420 7426.
36. Roberts, L. (2002) Mosquitoes and disease. Science 298 : 82 83.
37. Sano, Y., Harada, J., Tashiro, S., Gotoh-Mandeville, R., Maekawa, T. Ishii, S. (1999) ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. J Biol Chem 274 : 8949 8957.
38. Shin, S.W., Kokoza, V., Ahmed, A. Raikhel, A.S. (2002) Characterization of three alternatively spliced isoforms of the Rel/NF-kappa B transcription factor Relish from the mosquito Aedes aegypti. Proc Natl Acad Sci USA 99 : 9978 9983.
39. Shin, S.W., Kokoza, V., Lobkov, I. Raikhel, A.S. (2003) Relish-mediated immune deficiency in the transgenic mosquito Aedes aegypti. Proc Natl Acad Sci USA 100 : 2616 2621.
40. Shin, S.W., Kokoza, V., Bian, G., Cheon, H.M., Kim, Y.J. Raikhel, A.S. (2005) REL1, a homologue of Drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito Aedes aegypti. J Biol Chem 280 : 16499 16507.
41. Silverman, N. Maniatis, T. (2001) NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev 15 : 2321 2342.
42. Silverman, N., Zhou, R., Erlich, R.L., Hunter, M., Bernstein, E., Schneider, D. Maniatis, T. (2003) Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J Biol Chem 278 : 48928 48934.
43. Sluss, H.K., Han, Z., Barrett, T., Davis, R.J. Ip, Y.T. (1996) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev 10 : 2745 2758.
44. Vasselon, T., Hanlon, W.A., Wright, S.D. Detmers, P.A. (2002) Toll-like receptor 2 (TLR2) mediates activation of stress-activated MAP kinase p38. J Leukoc Biol 71 : 503 510.
45. Wang, Z., Harkins, P.C., Ulevitch, R.J., Han, J., Cobb, M.H. Goldsmith, E.J. (1997) The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci USA 94 : 2327 2332.
46. Zhang, N., Ahsan, M., Zhu, L., Sambucetti, L., Purchio, A. West, D. (2005) Regulation of I kappaB alpha expression involves both NF-kappaB and the MAP kinase signaling pathways. J Inflamm 2 : 10.