Proteomic analysis of hepatic iron overload in mice suggests dysregulation of urea cycle, impairment of fatty acid oxidation, and changes in the methylation cycle

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 292, Issue 6, 2007, Pages

  Petrak, Jiri ^a,b   Myslivcova, Denisa ^a   Man, Petr ^c   Cmejla, Radek ^a   Cmejlova, Jana ^a   Vyoral, Daniel ^a,d   Elleder, Milan ^e   Vulpe, Christopher D ^b  

^a INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e Charles University in Prague and General University Hospital in Prague   (Czech Republic)

Author keywords

2D PAGE; Hereditary hemochromatosis; Liver disease

Indexed keywords

CARBONYL IRON; FATTY ACID; IRON; LIVER PROTEIN; UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL MOUSE; CONTROLLED STUDY; DIET; FATTY ACID OXIDATION; IRON OVERLOAD; LIVER; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METHYLATION; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEOMICS; UREA CYCLE;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYMES; FATTY ACIDS; IRON COMPOUNDS; IRON OVERLOAD; LIVER; LIVER DISEASES; MALE; METHYLATION; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PROTEOMICS; SEVERITY OF ILLNESS INDEX; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UREA;

EID: 34447558581     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00455.2006     Document Type: Article

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