Regional dissection and determination of loosely bound and non-heme iron in the developing mouse brain

Brain Research

Volumn 1158, Issue 1, 2007, Pages 144-150

  Magaki, Shino ^a   Mueller, Claudius ^a   Yellon, Steven M ^a   Fox, James ^a   Kim, Joseph ^a   Snissarenko, Eugene ^a   Chin, Vernon ^a   Ghosh, Manik C ^b   Kirsch, Wolff M ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Iron; Iron regulatory protein 2; Microdissection; Neurodegeneration

Indexed keywords

IRON; IRON REGULATORY PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; MALE; MOUSE; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN; IRON; IRON REGULATORY PROTEIN 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

MUS;

EID: 34447550646     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.05.004     Document Type: Article

References (39)

1. Barnham K.J., Masters C.L., and Bush A.I. Neurodegenerative diseases and oxidative stress. Nat. Rev., Drug Discov. 3 (2004) 205-214
2. Beard J.L., Erikson K.M., and Jones B.C. Neurobehavioral analysis of developmental iron deficiency in rats. Behav. Brain Res. 134 (2002) 517-524
3. Bothe G.W.M., Bolivar V.J., Vedder M.J., and Geistfeld J.G. Genetic and behavioral differences among five inbred mouse strains commonly used in the production of transgenic and knockout mice. Genes Brain Behav. 3 (2004) 149-157
4. Bradbury M.W. Transport of iron in the blood-brain-cerebrospinal fluid system. J. Neurochem. 69 (1997) 443-454
5. Doraiswamy P.M., and Finefrock A.E. Metals in our minds: therapeutic implications for neurodegenerative disorders. Lancet Neurol. 3 (2004) 431-434
6. Galy B., Holter S.M., Klopstock T., Ferring D., Becker L., Kaden S., Wurst W., Grone H.J., and Hentze M.W. Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat. Genet. 38 (2006) 967-969
7. Glickstein H., El R.B., Shvartsman M., and Cabantchik Z.I. Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood 106 (2005) 3242-3250
8. Grabill C., Silva A.C., Smith S.S., Koretsky A.P., and Rouault T.A. MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice. Brain Res. 971 (2003) 95-106
9. Grantham-McGregor S., and Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J. Nutr. 131 (2001) 649-666
10. Gutteridge J.M. Iron and oxygen radicals in brain. Ann. Neurol. 32 (1992) S16-S21
11. Gutteridge J.M., Rowley D.A., and Halliwell B. Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem. J. 199 (1981) 263-265
12. Hallgren B., and Sourander P. The effect of age on the non-haemin iron in the human brain. J. Neurochem. 3 (1958) 41-51
13. Halliwell B., and Gutteridge J.M. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219 (1984) 1-14
14. Hentze M.W., Muckenthaler M.U., and Andrews N.C. Balancing acts: molecular control of mammalian iron metabolism. Cell 117 (2004) 285-297
15. Hu J., and Connor J.R. Demonstration and characterization of the iron regulatory protein in human brain. J. Neurochem. 67 (1996) 838-844
16. Huang X., Moir R.D., Tanzi R.E., Bush A.I., and Rogers J.T. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann. N. Y. Acad. Sci. 1012 (2004) 153-163
17. Jacobs A. Low molecular weight intracellular iron transport compounds. Blood 50 (1977) 433-439
18. Jeong S.Y., and David S. Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice. J. Neurosci. 26 (2006) 9810-9819
19. Kagan V.E., Kozlov A.V., Tyurina Y.Y., Shvedova A.A., and Yalowich J.C. Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells. Antioxid. Redox Signal. 3 (2001) 189-202
20. Kala S.V., Hasinoff B.B., and Richardson J.S. Brain samples from Alzheimer's patients have elevated levels of loosely bound iron. Int. J. Neurosci. 86 (1996) 263-269
21. Koeppen A.H. A brief history of brain iron research. J. Neurol. Sci. 207 (2003) 95-97
22. LaVaute T., Smith S., Cooperman S., Iwai K., Land W., Meyron-Holtz E., Drake S.K., Miller G., Abu-Asab M., Tsokos M., Switzer III R., Grinberg A., Love P., Tresser N., and Rouault T.A. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat. Genet. 27 (2001) 209-214
23. Leibold E.A., Gahring L.C., and Rogers S.W. Immunolocalization of iron regulatory protein expression in the murine central nervous system. Histochem. Cell Biol. 115 (2001) 195-203
24. Levenson C.W., and Tassabehji N.M. Iron and ageing: an introduction to iron regulatory mechanisms. Ageing Res. Rev. 3 (2004) 251-263
25. Maynard C.J., Cappai R., Volitakis I., Cherny R.A., White A.R., Beyreuther K., Masters C.L., Bush A.I., and Li Q.X. Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron. J. Biol. Chem. 277 (2002) 44670-44676
26. Nelson S.R., Pazdernik T.L., and Samson F.E. Measurement of loosely bound iron in brain regions using redox cycling and salicylate. Cell. Mol. Biol. (Noisy-le-grand) 46 (2000) 649-655
27. Paxinos G., and Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates. Ed. 2 (2000), Academic Press, San Diego
28. Perry G., Sayre L.M., Atwood C.S., Castellani R.J., Cash A.D., Rottkamp C.A., and Smith M.A. The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. CNS Drugs 16 (2002) 339-352
29. Roskams A.J., and Connor J.R. Iron, transferrin, and ferritin in the rat brain during development and aging. J. Neurochem. 63 (1994) 709-716
30. Rouault T.A. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2 (2006) 406-414
31. Sayre L.M., Perry G., and Smith M.A. Redox metals and neurodegenerative disease. Curr. Opin. Chem. Biol. 3 (1999) 220-225
32. Schneider D.R., Felt B.T., and Goldman H. Microwave radiation energy: a probe for the neurobiologist. Life Sci. 29 (1981) 643-653
33. Silver L.M. Mouse Genetics; Concepts and Applications (1995), Oxford Univ. Press, Oxford
34. Smith M.A., Harris P.L., Sayre L.M., and Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9866-9868
35. Smith S.R., Cooperman S., Lavaute T., Tresser N., Ghosh M., Meyron-Holtz E., Land W., Ollivierre H., Jortner B., Switzer III R., Messing A., and Rouault T.A. Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies. Ann. N. Y. Acad. Sci. 1012 (2004) 65-83
36. Smith S.R., Ghosh M.C., Ollivierre-Wilson H., Tong W.H., and Rouault T.A. Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol. Diseases 36 (2006) 283-287
37. Tarohda T., Yamamoto M., and Amamo R. Regional distribution of manganese, iron, copper, and zinc in the rat brain during development. Anal. Bioanal. Chem. 380 (2004) 240-246
38. Todorich B.M., and Connor J.R. Redox metals in Alzheimer's disease. Ann. N. Y. Acad. Sci. 1012 (2004) 171-178
39. Wallander M.L., Leibold E.A., and Eisenstein R.S. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim. Biophys. Acta 1763 (2006) 668-689