Polarization of B effector cells in Sjögren's syndrome

Autoimmunity Reviews

Volumn 6, Issue 7, 2007, Pages 427-431

  Daridon, Capucine ^a   Guerrier, Thomas ^a   Devauchelle, Valérie ^a   Saraux, Alain ^a   Pers, Jacques Olivier ^a   Youinou, Pierre ^a  

^a BREST UNIVERSITY HOSPITAL   (France)

Author keywords

B lymphocyte; Cytokine; Sj gren's syndrome

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 6; STAT1 PROTEIN; STAT4 PROTEIN;

AUTOIMMUNITY; B LYMPHOCYTE; CELL POLARITY; CYTOKINE PRODUCTION; EFFECTOR CELL; HELPER CELL; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; IN SITU HYBRIDIZATION; LYMPHOCYTE DIFFERENTIATION; REVIEW; RHEUMATOID ARTHRITIS; SALIVARY GLAND; SJOEGREN SYNDROME; T LYMPHOCYTE SUBPOPULATION;

AUTOIMMUNITY; B-LYMPHOCYTES; HUMANS; SALIVARY GLANDS; SJOGREN'S SYNDROME; TH1 CELLS; TH2 CELLS;

EID: 34447550506     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2007.01.010     Document Type: Review

References (32)

1. Tzioufas A.T., Youinou P., and Moutsopoulos H.M. Sjögren's syndrome. In: Maddison P.J., Isenberg D.A., Woo P., and Glass D.N. (Eds). Oxford Textbook of Rheumatology vol 2 (1998), Oxford Medical Publications, Oxford 1301-1317
2. Youinou P, Daridon C, Steinfeld S, Pers JO. A case for B-cells in the pathogenesis of Sjögren's syndrome. Trends Immunol in press.
3. Le Pottier L., Devauchelle V., Pers JO., Jamin C., Dueymes M., and Youinou P. The mosaic of B-cell subsets (with special emphasis on primary Sjögren's syndrome). Autoimmun Rev 6 (2007) 149-154
4. Pistoia V. Production of cytokines by human B cells in health and disease. Immunol Today 18 (1997) 343-350
5. Stockinger B., Zal T., Zal A., and Gray D. B cells solicit their own help from T cells. J Exp Med 183 (1996) 891-899
6. Takemura S., Klimiuk P.A., Braun A., Goronzy J.J., and Weyand C.M. T cell activation in rheumatoid synovium is B cell dependent. J Immunol 167 (2001) 4710-4718
7. Falcone M., Lee J., Patstone G., Yeung B., and Sarvetnick N. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J Immunol 161 (1998) 1163-1168
8. Pijpe J., van Imhoff G.W., Spijkervet F.K., Roodenburg J.L., Wolbink G.J., Mansour K., et al. Rituximab treatment in patients with primary Sjogren's syndrome: an open-label phase II study. Arthritis Rheum 52 (2005) 2740-2750
9. Devauchelle V, Pennec Y, Morvan J, Pers JO, Daridon C, Jousse S, et al. Improvement of Sjögren's syndrome after two infusions of rituximab. Arthritis Care Res in press.
10. Romagnani S. T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol 85 (2000) 9-18
11. Peng S.L., Szabo S.J., and Glimcher L.H. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A 99 (2002) 5545-5550
12. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
13. Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997) 587-596
14. Chakir H., Wang H., Lefebvre D.E., Webb J., and Scott F.W. T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3. J Immunol Methods 278 (2003) 157-169
15. Usui T., Preiss J.C., Kanno Y., Yao Z.J., Bream J.H., O'Shea J.J., et al. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med 203 (2006) 755-766
16. Usui T., Nishikomori R., Kitani A., and Strober W. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet. Immunity 18 (2003) 415-428
17. Nath N., Prasad R., Giri S., Singh A.K., and Singh I. T-bet is essential for the progression of experimental autoimmune encephalomyelitis. Immunology 118 (2006) 384-391
18. Weigmann B., and Neurath M.F. T-bet as a possible therapeutic target in autoimmune disease. Expert Opin Ther Targets 6 (2002) 619-622
19. Harris D.P., Haynes L., Sayles P.C., Duso D.K., Eaton S.M., Lepak N.M., et al. Reciprocal regulation of polarized cytokine production by effector B and T-cells. Nat Immunol 1 (2000) 475-482
20. Durali D., de Goer de Herve M.G., Giron-Michel J., Azzarone B., Delfraissy J.F., and Taoufik Y. In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment. Blood 102 (2003) 4084-4089
21. Harris D.P., Goodrich S., Gerth A.J., Peng S.L., and Lund F.E. Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 174 (2005) 6781-6790
22. Harris D.P., Goodrich S., Mohrs K., Mohrs M., and Lund F.E. Cutting edge: the development of IL-4-producing B-cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol 175 (2005) 7103-7107
23. Johansson-Lindbom B., and Borrebaeck C.A. Germinal center B-cells constitute a predominant physiological source of IL-4: implication for Th2 development in vivo. J Immunol 168 (2002) 3165-3172
24. Amel Kashipaz M.R., Huggins M.L., Lanyon P., Robins A., Powell R.J., and Todd I. Assessment of Be1 and Be2 cells in systemic lupus erythematosus indicates elevated interleukin-10 producing CD5+ B cells. Lupus 12 (2003) 356-363
25. Boumba D., Skopouli F.N., and Moutsopoulos H.M. Cytokine mRNA expression in the labial salivary gland tissues from patients with primary Sjogren's syndrome. Br J Rheumatol 34 (1995) 326-333
26. Ohyama Y., Nakamura S., Matsuzaki G., Shinohara M., Hiroki A., Fujimura T., et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 39 (1996) 1376-1384
27. Mitsias D.I., Tzioufas A.G., Veiopoulou C., Zintzaras E., Tassios I.K., Kogopoulou O., et al. The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjogren's syndrome. Clin Exp Immunol 128 (2002) 562-568
28. Pertovaara M., Antonen J., and Hurme M. Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome. Ann Rheum Dis 65 (2006) 666-670
29. Cross J.T., and Benton H.P. The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus. Inflamm Res 48 (1999) 255-261
30. Szodoray P., Alex P., Jonsson M.V., Knowlton N., Dozmorov I., Nakken B., et al. Distinct profiles of Sjogren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF. Clin Immunol 117 (2005) 168-176
31. Szodoray P., Alex P., Brun J.G., Centola M., and Jonsson R. Circulating cytokines in primary Sjogren's syndrome determined by a multiplex cytokine array system. Scand J Immunol 59 (2004) 592-599
32. Youinou P., Daridon C., Saraux A., Devauchelle V., and Pers J.O. Is B-cell the conductor of the lymphocyte orchestra in the salivary glands of patients with primary Sjogren's syndrome?. Clin Exp Rheumatol 24 (2006) 491-492