메뉴 건너뛰기




Volumn 48, Issue 5, 1999, Pages 255-261

The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus

Author keywords

Autoantibodies; B cells; Cytokines; SLE

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 6;

EID: 0033066019     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050456     Document Type: Review
Times cited : (64)

References (53)
  • 1
    • 0028782615 scopus 로고
    • Systemic lupus erythematosus
    • [1] Mills JA. Systemic lupus erythematosus. N Engl J Med 1994; 330: 1871-9.
    • (1994) N Engl J Med , vol.330 , pp. 1871-1879
    • Mills, J.A.1
  • 2
    • 0028990463 scopus 로고
    • Genetic contributions to lupus-like disease in (NZB × NZW) F1 mice
    • [2] Drake CG, Rozzo SJ, Vyse TJ, Palmer E, Kotzin BL. Genetic contributions to lupus-like disease in (NZB × NZW) F1 mice. Immunol Rev 1995; 144: 51-74.
    • (1995) Immunol Rev , vol.144 , pp. 51-74
    • Drake, C.G.1    Rozzo, S.J.2    Vyse, T.J.3    Palmer, E.4    Kotzin, B.L.5
  • 4
    • 0030917093 scopus 로고    scopus 로고
    • Cytokine manipulation by methotrexate treatment in murine experimental SLE
    • [4] Dayan M, Segal R, Mozes E. Cytokine manipulation by methotrexate treatment in murine experimental SLE. J Rheumatol 1997; 24: 1075-82.
    • (1997) J Rheumatol , vol.24 , pp. 1075-1082
    • Dayan, M.1    Segal, R.2    Mozes, E.3
  • 6
    • 0029047817 scopus 로고
    • Methotrexate treatment in murine experimental SLE: Clinical benefits associated with cytokine manipulation
    • [6] Segal R, Dayan M, Zinger H, Mozes E. Methotrexate treatment in murine experimental SLE: clinical benefits associated with cytokine manipulation. Clin Exp Immunol 1995; 101: 66-72.
    • (1995) Clin Exp Immunol , vol.101 , pp. 66-72
    • Segal, R.1    Dayan, M.2    Zinger, H.3    Mozes, E.4
  • 7
    • 0029157365 scopus 로고
    • Methotrexate action in rheumatoid arthritis: Stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells
    • [7] Seitz M, Loetscher P, Dewald B, Towbin H, Rordorf C, Gallati H, et al. Methotrexate action in rheumatoid arthritis: stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells. Brit J Rheumatol 1995; 34: 602-9.
    • (1995) Brit J Rheumatol , vol.34 , pp. 602-609
    • Seitz, M.1    Loetscher, P.2    Dewald, B.3    Towbin, H.4    Rordorf, C.5    Gallati, H.6
  • 8
    • 0022273898 scopus 로고
    • Murine models of systemic lupus erythematosus
    • [8] Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol 1985; 37: 269-363.
    • (1985) Adv Immunol , vol.37 , pp. 269-363
    • Theofilopoulos, A.N.1    Dixon, F.J.2
  • 9
    • 0028962115 scopus 로고
    • Role of interleukin-10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus
    • [9] Llorente L, Zou W, Levy Y, Richaud-Patin Y, Wijdenes J, Alcocer-Varela J, et al. Role of interleukin-10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 1995; 181: 839-14.
    • (1995) J Exp Med , vol.181 , pp. 839-914
    • Llorente, L.1    Zou, W.2    Levy, Y.3    Richaud-Patin, Y.4    Wijdenes, J.5    Alcocer-Varela, J.6
  • 10
    • 0029838992 scopus 로고    scopus 로고
    • Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB × NZW) F1 mice
    • [10] Reninger L, Winkler TH, Kalberer CP, Jourdan M, Melchers K, Rolink AG. Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB × NZW) F1 mice. J Exp Med 1996; 184: 853-61.
    • (1996) J Exp Med , vol.184 , pp. 853-861
    • Reninger, L.1    Winkler, T.H.2    Kalberer, C.P.3    Jourdan, M.4    Melchers, F.5    Rolink, A.G.6
  • 11
    • 0026560191 scopus 로고
    • Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: Analysis of IL-6 production and IL-6R expression
    • [11] Kitani A, Hara M, Hirose T, Harigai M, Suzuki K, Kawakami M, et al. Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression. Clin Exp Immunol 1992; 88: 75-83.
    • (1992) Clin Exp Immunol , vol.88 , pp. 75-83
    • Kitani, A.1    Hara, M.2    Hirose, T.3    Harigai, M.4    Suzuki, K.5    Kawakami, M.6
  • 12
    • 0026597747 scopus 로고
    • Cytokine abnormalities in human lupus
    • [12] Linker-Israeli M. Cytokine abnormalities in human lupus. Clin Immunopathol 1992; 63: 10-2.
    • (1992) Clin Immunopathol , vol.63 , pp. 10-12
    • Linker-Israeli, M.1
  • 13
    • 0026445046 scopus 로고
    • Cytokines and Ly-1 (B1) B cells
    • [13] O'Garra A, Howard M. Cytokines and Ly-1 (B1) B cells. Intl Rev Immunol 1992; 8: 219-34.
    • (1992) Intl Rev Immunol , vol.8 , pp. 219-234
    • O'Garra, A.1    Howard, M.2
  • 14
    • 0028990471 scopus 로고
    • Inquiry into murine and human lupus
    • [14] Klinman DM, Steinberg AD. Inquiry into murine and human lupus. Immunol Rev 1995; 144: 157-93.
    • (1995) Immunol Rev , vol.144 , pp. 157-193
    • Klinman, D.M.1    Steinberg, A.D.2
  • 15
    • 0024583943 scopus 로고
    • Responses of B cells from autoimmune mice to IL-5
    • [15] Umland SP, Go NF, Cupp JE, Howard M. Responses of B cells from autoimmune mice to IL-5. J Immunol 1989; 142: 1528-35.
    • (1989) J Immunol , vol.142 , pp. 1528-1535
    • Umland, S.P.1    Go, N.F.2    Cupp, J.E.3    Howard, M.4
  • 16
    • 0030962357 scopus 로고    scopus 로고
    • Production and roles of IL-6, IL-10, and IL-13 in B-lymphocyte malignancies and in B-lymphocyte hyperactivity of HIV infection and autoimmunity
    • [16] Emilie D, Zon W, Fior R, Llorente L, Durandy A, Crevon M-C, et al. Production and roles of IL-6, IL-10, and IL-13 in B-lymphocyte malignancies and in B-lymphocyte hyperactivity of HIV infection and autoimmunity. Methods 1997; 11: 133-42.
    • (1997) Methods , vol.11 , pp. 133-142
    • Emilie, D.1    Zon, W.2    Fior, R.3    Llorente, L.4    Durandy, A.5    Crevon, M.-C.6
  • 17
    • 0030972737 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: Demographics, prognosis, and outcome
    • [17] Klippel JH. Systemic lupus erythematosus: demographics, prognosis, and outcome. J Rheumatol 1997; 24 (Suppl 48): 67-71.
    • (1997) J Rheumatol , vol.24 , Issue.SUPPL. 48 , pp. 67-71
    • Klippel, J.H.1
  • 18
    • 0031239964 scopus 로고    scopus 로고
    • Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus-a analyses of strain, gender, and age effects
    • [18] McMurray RW, Huffman RW, Nelson W, Walker SE. Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus-a analyses of strain, gender, and age effects. Clin Immunol Immunopathol 1997; 84: 260-8.
    • (1997) Clin Immunol Immunopathol , vol.84 , pp. 260-268
    • McMurray, R.W.1    Huffman, R.W.2    Nelson, W.3    Walker, S.E.4
  • 20
    • 0027531439 scopus 로고
    • Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice
    • [20] Reap EA, Sobel ES, Cohen PL, Eisenberg RA. Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice. J Exp Med 1993; 177: 69-78.
    • (1993) J Exp Med , vol.177 , pp. 69-78
    • Reap, E.A.1    Sobel, E.S.2    Cohen, P.L.3    Eisenberg, R.A.4
  • 23
    • 0027376265 scopus 로고
    • Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus
    • [23] Nagafuchi H, Suzuki N, Mizushima Y, Sakane T. Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus. J Immunol 1993; 151: 6525-6534.
    • (1993) J Immunol , vol.151 , pp. 6525-6534
    • Nagafuchi, H.1    Suzuki, N.2    Mizushima, Y.3    Sakane, T.4
  • 24
    • 0023851809 scopus 로고
    • The essential role of B cell stimulatory factor 2 (BSF2/IL-6) for the terminal differentiation of B cells
    • [24] Muraguchi A, Hirano T, Tang B, Matsuda T, Horii Y, Nakajima K, et al. The essential role of B cell stimulatory factor 2 (BSF2/IL-6) for the terminal differentiation of B cells. J Exp Med 1988; 167: 332-44.
    • (1988) J Exp Med , vol.167 , pp. 332-344
    • Muraguchi, A.1    Hirano, T.2    Tang, B.3    Matsuda, T.4    Horii, Y.5    Nakajima, K.6
  • 25
    • 0021256525 scopus 로고
    • Human helper T cell factor(s) IV: Demonstration of a human late-acting B cell differentiation factor acting on staphylococcus aureus Cowan I-stimulated B cells
    • [25] Hirano T, Teranishi T, Lin B, Onoue K. Human helper T cell factor(s) IV: demonstration of a human late-acting B cell differentiation factor acting on staphylococcus aureus Cowan I-stimulated B cells. J Immunol 1984; 133: 798-802.
    • (1984) J Immunol , vol.133 , pp. 798-802
    • Hirano, T.1    Teranishi, T.2    Lin, B.3    Onoue, K.4
  • 26
    • 0027930909 scopus 로고
    • Interleukin 6 promotes murine lupus in NZB/NZW F1 mice
    • [26] Finck BK, Chan B, Wofsy D. Interleukin 6 promotes murine lupus in NZB/NZW F1 mice. J Clin Invest 1994; 94: 585-91.
    • (1994) J Clin Invest , vol.94 , pp. 585-591
    • Finck, B.K.1    Chan, B.2    Wofsy, D.3
  • 27
    • 0030004658 scopus 로고    scopus 로고
    • Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies
    • [27] Villunger A, Egle A, Kos M, Hittmair A, Maly K, Greil R. Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies. Int J Cancer 1996; 65: 498-505.
    • (1996) Int J Cancer , vol.65 , pp. 498-505
    • Villunger, A.1    Egle, A.2    Kos, M.3    Hittmair, A.4    Maly, K.5    Greil, R.6
  • 28
    • 0023737261 scopus 로고
    • Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus
    • [28] Tanaka Y, Saito K, Shirakawa F, Ota T, Suzuki H, Eto S, et al. Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus. J Immunol 1988; 141: 3043-9.
    • (1988) J Immunol , vol.141 , pp. 3043-3049
    • Tanaka, Y.1    Saito, K.2    Shirakawa, F.3    Ota, T.4    Suzuki, H.5    Eto, S.6
  • 29
    • 0029788923 scopus 로고
    • Expression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: A prospective study
    • [29] Chan EY-T, Lau C-S, Zola H. Expression of IL-2R, IL-4R, IL-6R on Peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: a prospective study. J Clin Pathol 1994; 49: 660-3.
    • (1994) J Clin Pathol , vol.49 , pp. 660-663
    • Chan, E.Y.-T.1    Lau, C.-S.2    Zola, H.3
  • 31
    • 0028081880 scopus 로고
    • Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice
    • [31] Ishida H, Muchamuel T, Sakaguchi S, Andrade S, Menon S, Howard M. Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 Mice. J Exp Med 1994; 179: 305-10.
    • (1994) J Exp Med , vol.179 , pp. 305-310
    • Ishida, H.1    Muchamuel, T.2    Sakaguchi, S.3    Andrade, S.4    Menon, S.5    Howard, M.6
  • 32
    • 0023685762 scopus 로고
    • Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
    • [32] Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science 1988; 241: 825-8.
    • (1988) Science , vol.241 , pp. 825-828
    • Yamasaki, K.1    Taga, T.2    Hirata, Y.3    Yawata, H.4    Kawanishi, Y.5    Seed, B.6
  • 33
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer, gp130
    • [33] Hibi M, Murakami M, Saito M, Hirano T, Toga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990; 63: 1149-57.
    • (1990) Cell , vol.63 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3    Hirano, T.4    Toga, T.5    Kishimoto, T.6
  • 34
    • 0027199126 scopus 로고
    • IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase
    • [34] Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K., Yamanishi K, et al. IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 1993; 260: 1808-10.
    • (1993) Science , vol.260 , pp. 1808-1810
    • Murakami, M.1    Hibi, M.2    Nakagawa, N.3    Nakagawa, T.4    Yasukawa, K.5    Yamanishi, K.6
  • 35
    • 0028064835 scopus 로고
    • High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130
    • [35] Ward LD, Howlett GJ, Discolo G, Yasukawa K, Hammacher A, Moritz RL, et al. High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J Biol Chem 1994; 269: 23286-9.
    • (1994) J Biol Chem , vol.269 , pp. 23286-23289
    • Ward, L.D.1    Howlett, G.J.2    Discolo, G.3    Yasukawa, K.4    Hammacher, A.5    Moritz, R.L.6
  • 36
    • 0029831603 scopus 로고    scopus 로고
    • Cytokine gene expression in the MRL/lpr model of lupus nephritis
    • [36] Lemay S, Mao C, Singh AK. Cytokine gene expression in the MRL/lpr model of lupus nephritis. Kidney Int 1996; 50: 85-93.
    • (1996) Kidney Int , vol.50 , pp. 85-93
    • Lemay, S.1    Mao, C.2    Singh, A.K.3
  • 38
    • 0024408824 scopus 로고
    • Two types of mouse T helper cells. IV TH2 clones secrete a factor that inhibits cytokine production by TH1 clones
    • [38] Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cells. IV TH2 clones secrete a factor that inhibits cytokine production by TH1 clones. J Exp Med 1989; 170: 2081-95.
    • (1989) J Exp Med , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 39
    • 0026514309 scopus 로고
    • Differential effects of interleukin-4 and -10 on interleukin-2 induced interferon γ synthesis and lymphokine-activated killer activity
    • [39] Hsu DH, Moore KW, Spits H. Differential effects of interleukin-4 and -10 on interleukin-2 induced interferon γ synthesis and lymphokine-activated killer activity. Int Immunol 1992; 4: 563-9.
    • (1992) Int Immunol , vol.4 , pp. 563-569
    • Hsu, D.H.1    Moore, K.W.2    Spits, H.3
  • 41
    • 0025673971 scopus 로고
    • Interleukin 10 (IL-10), a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells
    • [41] Go NF, Castle BE, Barrett R, Kastelein R, Dang W, Mosmann TR, et al. Interleukin 10 (IL-10), a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Fxp Med 1990; 172: 1625-31.
    • (1990) J Fxp Med , vol.172 , pp. 1625-1631
    • Go, N.F.1    Castle, B.E.2    Barrett, R.3    Kastelein, R.4    Dang, W.5    Mosmann, T.R.6
  • 42
    • 0026094306 scopus 로고
    • IL-10 inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • [42] de Waal Malefyt F, Abrams J, Bennett B, Figdor C, de Vries J. IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-20.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, F.1    Abrams, J.2    Bennett, B.3    Figdor, C.4    De Vries, J.5
  • 43
    • 0030751975 scopus 로고    scopus 로고
    • Interleukin 10 response abnormalities in systemic lupus erythematosus
    • [43] Mongan AE, Ramdahin S, Warrington RJ. Interleukin 10 response abnormalities in systemic lupus erythematosus. Scand J Immunol 1997; 46: 406-12.
    • (1997) Scand J Immunol , vol.46 , pp. 406-412
    • Mongan, A.E.1    Ramdahin, S.2    Warrington, R.J.3
  • 44
    • 0023874728 scopus 로고
    • Tumor necrosis factor-α in murine autoimmune "lupus" nephritis
    • [44] Jacob CO, McDevitt HO. Tumor necrosis factor-α in murine autoimmune "lupus" nephritis. Nature 1988; 331: 356-8.
    • (1988) Nature , vol.331 , pp. 356-358
    • Jacob, C.O.1    McDevitt, H.O.2
  • 45
    • 0024341726 scopus 로고
    • Chronic therapy with recombinant tumor necrosis factor-α in autoimmune NZB/NZW F1 mice
    • [45] Gordon C, Ranges GE, Greenspan JS, Wofsy D. Chronic therapy with recombinant tumor necrosis factor-α in autoimmune NZB/NZW F1 mice. Clin Immunol Immunopathol 1989; 52: 421.
    • (1989) Clin Immunol Immunopathol , vol.52 , pp. 421
    • Gordon, C.1    Ranges, G.E.2    Greenspan, J.S.3    Wofsy, D.4
  • 46
  • 47
    • 0028350053 scopus 로고
    • Expression cloning and characterization of a human IL-10 receptor
    • [47] Liu Y, Wei SH-Y, Ho AS-Y, de Waal Malefyt R, Moore KW. Expression cloning and characterization of a human IL-10 receptor. J Immunol 1994; 152: 1821-9.
    • (1994) J Immunol , vol.152 , pp. 1821-1829
    • Liu, Y.1    Wei, S.-Y.2    Ho, A.-Y.3    De Waal Malefyt, R.4    Moore, K.W.5
  • 48
    • 0020681403 scopus 로고
    • The "ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice
    • [48] Hayakawa K, Hardy RR, Parks DR, Herzenberg LA. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med 1983; 157: 202-18.
    • (1983) J Exp Med , vol.157 , pp. 202-218
    • Hayakawa, K.1    Hardy, R.R.2    Parks, D.R.3    Herzenberg, L.A.4
  • 49
    • 0022648349 scopus 로고
    • Peritoneal ly-1 B cells: Genetic control, autoantibody production, increased lambda light chain expression
    • [49] Hayakawa K, Hardy RR, Herzenberg LA. Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression. Eur J Immunol 1986; 16: 450-6.
    • (1986) Eur J Immunol , vol.16 , pp. 450-456
    • Hayakawa, K.1    Hardy, R.R.2    Herzenberg, L.A.3
  • 50
    • 0023201406 scopus 로고
    • Ly-1 B helper cells in autoimmune "viable motheaten" mice
    • [50] Sherr DH, Dorf ME, Gibson M, Sidman CL. Ly-1 B Helper cells in autoimmune "viable motheaten" mice. J Immunol 1987; 139: 1811.
    • (1987) J Immunol , vol.139 , pp. 1811
    • Sherr, D.H.1    Dorf, M.E.2    Gibson, M.3    Sidman, C.L.4
  • 51
    • 0028122043 scopus 로고
    • Properties and functions of interleukin-10
    • [51] Mosmann TR. Properties and functions of interleukin-10. Adv Immunol 1994; 56: 1-26.
    • (1994) Adv Immunol , vol.56 , pp. 1-26
    • Mosmann, T.R.1
  • 52
    • 0028963222 scopus 로고
    • Experimental therapy of systemic lupus erythematosus: The treatment of NZB/W mice with mouse soluble interferon-γ receptor inhibits the onset of glomerulonephritis
    • [52] Ozmen L, Roman D, Fountoulakis M, Schmid G, Ryffel B, Garotta G. Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-γ receptor inhibits the onset of glomerulonephritis. Eur J Immunol 1995; 25: 6-12.
    • (1995) Eur J Immunol , vol.25 , pp. 6-12
    • Ozmen, L.1    Roman, D.2    Fountoulakis, M.3    Schmid, G.4    Ryffel, B.5    Garotta, G.6
  • 53
    • 0029021257 scopus 로고
    • Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery
    • [53] Raz E. Dudler J, Lotz M, Baird SH, Berry CC, Eisenberg RA, et al. Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 1995; 4: 286-92.
    • (1995) Lupus , vol.4 , pp. 286-292
    • Raz, E.1    Dudler, J.2    Lotz, M.3    Baird, S.H.4    Berry, C.C.5    Eisenberg, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.