Th2 cytokine genotypes are associated with a milder form of primary Sjögren's syndrome

Annals of the Rheumatic Diseases

Volumn 65, Issue 5, 2006, Pages 666-670

  Pertovaara, M ^a   Antonen, J ^a   Hurme, M ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; GAMMA INTERFERON; IMMUNOGLOBULIN A; INTERLEUKIN 13; INTERLEUKIN 4;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA POLYMORPHISM; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PURPURA; SJOEGREN SYNDROME; TH1 CELL; TH2 CELL;

AGED; CELL DIFFERENTIATION; CYTOKINES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROZYGOTE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-13; INTERLEUKIN-4; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SJOGREN'S SYNDROME; TH1 CELLS; TH2 CELLS;

EID: 33646231015     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2005.040956     Document Type: Article

References (32)

1. Sawalha AH, Potts R, Schmid W, Scofield RH, Harley JB. The genetics of primary Sjögren's syndrome. Curr Rheumatol Rep 2003;5, 324-32.
2. Roon JAG, Bijlsma JWJ. Th2 mediated regulation in RA and the spondyloarthropathies. Ann Rheum Dis 2002;61:951-4.
3. Romagnani S. Immunologic influences on allergy and the Th1/Th2 balance. J Allergy Clin Immunol, 2004;113:395-400.
4. Fox RI, Kang HI, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol 1994;152:5532-9.
5. Ajjan RA, McIntosh RS, Waterman EA, Watson PF, Franklin CD, Yeoman CM, et al. Analysis of the T cell receptor Vα repertoire and cytokine gene expression in Sjögren's syndrome. Br J Rheumatol 1998;37:179-85.
6. Konttinen YT, Kemppinen P, Koski H, Li TF, Jumppanen M, Hietanen J, et al. T(H) 1 cytokines are produced in labial salivary glands in Sjögren's syndrome, but also in healthy individuals. Scand J Rheumatol 1999;28:106-12.
7. Mitsias DI, Tzioufas AG, Veiopoulou C, Zintzaras E, Tassios IK, Kogopoulou O, et al. The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjögren's syndrome. Clin Exp Immunol 2002;128:562-8.
8. Kolkowski EC, Reth P, Pelusa F, Bosch J, Pujol-Borrell R, Coll J, et al. Th1 predominance and perform expression in minor salivary glands from patients with primary Sjögren's syndrome. J Autoimmun 1999;13:155-02.
9. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 1996;39:1376-84.
10. Villarreal GM, Alcocer-Varela J, Llorente L. Differential interleukin (IL)-10 and IL-13 expression in salivary glands and peripheral blood mononuclear cells from patients with primary Sjögren's syndrome. Immunol Lett 1996;49:105-9.
11. Jabs DA, Lee B, Whittum-Hudson JA, Prendergast RA. Th1 versus Th2 immune responses in autoimmune lacrimal gland diseases in MRL/Mp mice. Invest Ophthalmol Vis Sci 2000;41:826-31.
12. Akpek EK, Jabs DA, Gerard HC, Prendergast RA, Hudson AP, Lee B, et al. Chemokines in autoimmune lacrimal gland disease in MRL/Mp mice. Invest Ophthalmol Vis Sci 2004;45:185-90.
13. Nakashima H, Miyake K, Inoue E, Shimizu S, Akahoshi M, Tanaka Y, et al. Association between IL-4 genotype and IL-4 production in the Japanese population. Genes Immun 2002;3:107-9.
14. Vercelli D. Genetics of IL-13 and functional relevance of IL-13 variants. Curr Opin Allergy Clin Immunol 2002;2:389-93.
15. Pravica V, Perrey C, Stevens A, Lee J-H. Hutchinson IV. A single nucleotide polymorphism in the first intron of the human IFN-γ gene: absolute correlation wim a polymorphic CA microsatellite marker of high IFN-γ production, Hum Immunol 2000;61:863-6.
16. Rossouw M, Nel HJ, Cooke GS, van Helden PD, Hoal EG. Association between tuberculosis and a polymorphic NF-κB binding site in the interferon γ gene. Lancet 2003;361:1871-2.
17. Fox RI, Robinson CA, Curd JG, Kozin F, Howell FV. Sjögren's syndrome. Proposed criteria for classification. Arthritis Rheum 1986;29:577-85.
18. Chishom DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol 1968;21:656-60.
19. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. European study group on classification for Sjögren's syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European consensus group, Ann Rheum Dis, 2002;61:554-9.
20. Pertovaara M, Korpela M, Kouri T, Pasternack A. The occurrence of renal involvement in primary Sjögren's syndrome: a study of 78 patients. Rheumatology 1999;38:1113-20.
21. Noguchi E, Nukaga-Nishio Y, Jian Z, Yokouchi Y, Kamioka M, Yamakawa-Kobayashi K, et al. Haplotypes of the 5′ region of the IL-4 gene and SNPs in the intergene sequence between the IL-4 and IL-13 genes are associated with atopic asthma. Hum Immunol 2001;62:1251-7.
22. He J-Q, Chan-Yeung M, Becker AB, Dimich-Ward H, Ferguson AC, Manfreda J, et al. Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children. Genes Immun 2003;4:385-9.
23. Garcia-Carrasco M, Font J, Filella X, Cervera R, Ramos-Casals M, Sisó A, et al. Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome: correlation with clinical and immunological features. Clin Exp Rheumatology, 2001;19:411-15.
24. Kohriyama K, Katayama Y. Disproportion of helper T cell subsets in peripheral blood of patients with primary Sjögren's syndrome. Autoimmunity 2000;32:67-72.
25. Hagiwara E, Pando J, Ishigatsubo Y, Klinman DM. Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J Rheumatol 1998;25:89-93.
26. Hulkkonen J, Pertovaara M, Antonen J, Lahdenpohja N, Pasternack A, Hurme M. Genetic associations between IL-10 promoter region polymorphism and primary Sjögren's syndrome. Arthritis Rheum 2001;44:176-9.
27. Font J, Carcia-Carrasco M, Ramos-Casals M, Aldea AI, Cervera R, Vives J, et al. The role of interleukin-10 promoter polymorphism in the expression of primary Sjögren's syndrome. Rheumatology 2002;41:1025-30.
28. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994;264:1152-6.
29. Skopouli FN, Dafni U, Ioannidis JP, Moutsopoulos HM. Clinical evolution, and morbidity and mortality of primary Sjögren's syndrome. Semin Arthritis Rheum 2000;29:296-304.
30. Michalski J, Daniels T, Talal N, Grey H. Beta-2 microglobulin and lymphocytic infiltration in Sjögren's syndrome. N Engl J Med 1975;293:1228-31.
31. Pertovaara M, Pukkala E, Laippala P, Miettinen A, Pasternack A. A longitudinal cohort study of Finnish patients with primary Sjögren's syndrome. Clinical, immunological and epidemiological aspects. Ann Rheum Dis 2001;60:467-72.
32. Genevay S, Di Giovine FS, Perneger TV, Silvestri T, Stingelin S, Duff G, et al. Association of interleukin-4 and interleukin-1B gene variants with Larsen score progression in rheumatoid arthritis. Arthritis Rheum 2002;47:303-9.