Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n - 3 polyunsaturated fatty acids

NeuroToxicology

Volumn 28, Issue 4, 2007, Pages 707-719

  Paletz, Elliott M ^a   Day, Jeremy J ^b   Craig Schmidt, Margaret C ^c   Newland, M Christopher ^c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c AUBURN UNIVERSITY   (United States)

Author keywords

Aging; Development; Discrimination reversal; Fish oil; Methylmercury; Operant behavior; PUFA

Indexed keywords

COCONUT OIL; FISH OIL; LINOLEIC ACID; METHYLMERCURY; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONTROLLED STUDY; CORRELATION ANALYSIS; DIETARY INTAKE; FEMALE; LATENT PERIOD; MALE; NEUROPROTECTION; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; SIBLING; SPATIAL DISCRIMINATION; VISUAL DISCRIMINATION;

AGING; ANIMALS; ANIMALS, NEWBORN; DISCRIMINATION LEARNING; FATTY ACIDS, OMEGA-3; FEMALE; FUNCTIONAL LATERALITY; MALE; METHYLMERCURY COMPOUNDS; MULTIVARIATE ANALYSIS; PHOTIC STIMULATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, LONG-EVANS; REVERSAL LEARNING; SPACE PERCEPTION;

RATTUS;

EID: 34447326141     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2007.05.001     Document Type: Article

References (75)

1. Barone Jr. S., Haykal-Coates N., Parran D.K., and Tilson H.A. Gestational exposure to methylmercury alters the developmental pattern of trk-like immunoreactivity in the rat brain and results in cortical dysmorphology. Brain Res Dev Brain Res 109 (1998) 13-31
2. Becker C.C., and Kyle D.J. The importance of DHA in optimal cognitive function in rodents. In: Mostofsky D., Yehuda S., and Salem Jr. N. (Eds). Fatty Acids: Physiological and Behavioral Functions (2001), Humana Press Inc., Totowa, NJ 357-375
3. Berlin M., Grant C.A., Hellberg J., Hellstrom J., and Schultz A. Neurotoxicity of methylmercury in squirrel monkeys. Cerebral cortical pathology, interference with scotopic vision, and changes in operant behavior. Arch Environ Health 30 (1975) 340-348
4. Brown N.O., Parks J.L., and Green R.W. Canine urolithiasis: retrospective analysis of 438 cases. J Am Assoc Lab Anim Sci 110 (1977) 414-418
5. Buelke-Sam J., Kimmel C.A., Adams J., Nelson C.J., Vorhees C.V., Wright D.C., et al. Collaborative behavioral teratology study: results. Neurobehav Toxicol Teratol 7 (1985) 591-624
6. Burbacher T.M., Grant K.S., and Mottet N.K. Retarded object permanence development in methylmercury exposed Macaca fascicularis infants. Dev Psychol 22 (1988) 771-776
7. Burbacher T.M., Rodier P.M., and Weiss B. Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals. Neurotoxicol Teratol 12 (1990) 191-202
8. Bushnell P.J. Behavioral effects of acute p-xylene inhalation in rats: autoshaping, motor activity, and reversal learning. Neurotoxicol Teratol 10 (1988) 569-577
9. Bushnell P.J., and Bowman R.E. Persistence of impaired reversal learning in young monkeys exposed to low levels of dietary lead. J Toxicol Environ Health 5 (1979) 1015-1023
10. Chudasama Y., and Robbins T.W. Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: Further evidence for the functional heterogeneity of the rodent frontal cortex. J Neurosci 23 (2003) 8771-8780
11. Davidson P.W., Myers G.J., Cox C., Axtell C., Shamlaye C., Sloane-Reeves J., et al. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA 280 (1998) 701-707
12. Davidson P.W., Myers G.J., Cox C., Wilding G.E., Shamlaye C.F., Huang L.S., et al. Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohort. Neurotoxicol Teratol 28 (2006) 529-535
13. Davison M., and McCarthy D. The Matching Law: A Research Review (1988), Erlbaum, Hillsdale, NJ
14. Day J.J., Reed M.N., and Newland M.C. Neuromotor deficits and mercury concentrations in rats exposed to methyl mercury and fish oil. Neurotoxicol Teratol 27 (2005) 629-641
15. Egeland G.M., and Middaugh J.P. Balancing fish consumption benefits with mercury exposure. Science 278 (1997) 1904-1905
16. Elsner J., Hodel B., Suter K.E., Oelke D., Ulbrich B., Schreiner G., et al. Detection limits of different approaches in behavioral teratology, and correlation of effects with neurochemical parameters. Neurotoxicol Teratol 10 (1988) 155-167
17. Gilbert S.G., and Rice D.C. Low-level lifetime lead exposure produces behavioral toxicity (spatial discrimination reversal) in adult monkeys. Toxicol Appl Pharmacol 91 (1987) 484-490
18. Gilbert S.G., Burbacher T.M., and Rice D.C. Effects of in utero methylmercury exposure on a spatial delayed alternation task in monkeys. Toxicol Appl Pharmacol 123 (1993) 130-136
19. Goldey E.S., O'Callaghan J.P., Stanton M.E., Barone Jr. S., and Crofton K.M. Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury. Fundam Appl Toxicol 23 (1994) 447-464
20. Grandjean P., Weihe P., White R.F., Debes F., Araki S., Yokoyama K., et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19 (1997) 417-428
21. Greiner R.S., Moriguchi T., Hutton A., Slotnick B.M., and Salem N. Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. Lipids 34 (1999) S239-S243
22. Gunderson V.M., Grant-Webster K.S., Burbacher T.M., and Mottet N.K. Visual recognition memory deficits in methylmercury-exposed Macaca fascicularis infants. Neurotoxicol Teratol 10 (1988) 373-379
23. Gunderson V.M., Grant-Webster K.S., Burbacher T.M., and Mottet N.K. Retarded object permanence development in methylmercury exposed Macaca fascicularis infants. Dev Psychol 22 (1988) 1986
24. Kalmijn S., Fesken E.J., Launer L.J., and Kromhout D. Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 145 (1997) 33-41
25. Kalmijn S., van Boxtel M.P., Ocke M., Verschuren W.M., Kromhout D., and Launer L.J. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology 62 (2004) 275-280
26. Kheramin S., Body S., Herrera F.M., Bradshaw C.M., Szabadi E., Deakin J.F., et al. The effect of orbital prefrontal cortex lesions on performance on a progressive ratio schedule: Implications for models of inter-termporal choice. Behav Brain Res 156 (2005) 145-152
27. Kinjo Y., Higashi H., Nakano A., Sakamoto M., and Sakai R. Profile of subjective complaints and activities of daily living among current patients with Minamata disease after 3 decades. Environ Res 63 (1993) 241-251
28. Klurfeld D.M. Kidney and bladder stones in rodents fed purified diets. J Nutr 132 (2002) 3482
29. Kolb B., and Wishaw I.Q. Fundamentals of Human Neuropsychology. 5th ed (2003), Worth Publishers, New York
30. Magos L. The absorption, distribution, and excretion of methyl mercury. In: Eccles C.U., and Annau Z. (Eds). The toxicity of methyl mercury (1987), Johns Hopkins, Baltimore 24-44
31. Mahaffey K.R. Methylmercury exposure and neurotoxicity. JAMA 280 (1998) 737-738
32. Mandel N. Mechanism of stone formation. Semin Nephrol 16 (1996) 364-374
33. Morris M.C., Evans D.A., Tangney C.C., Bienias J.L., and Wilson R.S. Fish consumption and cognitive decline with age in a large community study. Arch Neurol 62 (2005) 1849-1853
34. Murray T.K., Ridley R.M., Snape M.F., and Cross A.J. The effect of dizocilpine (MK-801) on spatial and visual discrimination tasks in the rat. Behav Pharmacol 6 (1995) 540-549
35. Nakada S., and Imura N. Susceptibility of lipids to mercurials. J Appl Toxicol 3 (1983) 131-134
36. National Research Council. Toxicological effects of methylmercury (2000), National Academy Press, Washington, DC
37. Newland M.C., and Reile P.A. Blood and brain mercury levels after chronic gestational exposure to methylmercury in rats. Toxicol Sci 50 (1999) 106-116
38. Newland M.C., and Rasmussen E.B. Aging unmasks adverse effects of gestational exposure to methylmercury in rats. Neurotoxicol Teratol 22 (2000) 819-828
39. Newland M.C., and Paletz E.M. Animal studies of methylmercury and PCBs: what do they tell us about expected effects in humans?. Neurotoxicology 21 (2000) 1003-1027
40. Newland M.C., Reile P.A., and Langston J.L. Gestational exposure to methylmercury retards choice in transition in aging rats. Neurotoxicol Teratol 26 (2004) 179-194
41. Newland M.C., Yezhou S., Logdberg B., and Berlin M. Prolonged behavioral effects of in utero exposure to lead or methyl mercury: reduced sensitivity to changes in reinforcement contingencies during behavioral transitions and in steady state. Toxicol Appl Pharmacol 126 (1994) 6-15
42. Newland M.C., Donlin W.D., Paletz E.M., and Banna K.M. Developmental behavioral toxicitiy of methylmercury: consequences, conditioning, and cortex. In: Levin E.D., and Buccafusco J.J. (Eds). Animal models of cognitive impairment (2006), CRC Press, Boca Raton, FL 101-146
43. Newland M.C., Reed M.N., LeBlanc A., and Donlin W.D. Brain and blood mercury and selenium after chronic and developmental exposure to methylmercury. Neurotoxicology 27 (2006) 710-720
44. Newland M.C., Reile P.A., Sartin E.A., Hart M., Craig-Schmidt M.C., Mandel I., et al. Urolithiasis in rats consuming a dl bitartrate form of choline in a purified diet. Comp Med 55 (2005) 354-367
45. Okaniwa Y., Yuasa S., Yamamoto N., Watanabe S., Kobayashi T., Okuyama H., et al. A high linoleate and a high alpha-linolenate diet induced changes in learning behavior of rats. Effects of a shift in diets and reversal of training stimuli. Biol Pharm Bull 19 (1996) 536-540
46. O'Kusky J. Methylmercury poisoning of the developing nervous system: morphological changes in neuronal mitochondria. Acta Neuropathol 61 (1983) 116-122
47. Paletz E.M., Craig-Schmidt M.C., and Newland M.C. Gestational exposure to methylmercury and n - 3 fatty acids: effects on high- and low-rate operant behavior in adulthood. Neurotoxicol Teratol 28 (2006) 59-73
48. Parran D.K., Barone Jr. S., and Mundy W.R. Methylmercury decreases NGF-induced TrkA autophosphorylation and neurite outgrowth in PC12 cells. Brain Res Dev Brain Res 141 (2003) 71-81
49. Prusky G.T., Harker K.T., Douglas R.M., and Whishaw I.Q. Variation in visual acuity within prigmented, and between pigmented and albino rat strains. Behav Brain Res 136 (2002) 339-348
50. Reed M.N., Paletz E.M., and Newland M.C. Gestational exposure to methylmercury and selenium: effects on a spatial discrimination procedure in adulthood. Neurotoxicology 27 (2006) 721-732
51. Reed MN, Banna KM, Donlin WD, Newland MC. Effects of gestational exposure to methylmercury and dietary selenium on reinforcement efficacy in adulthood. Neurotoxicol Teratol, under review.
52. Reisbick S., and Neuringer M. Omega-3 fatty acid deficiency and behavior. In: Yehuda S., and Mostofsky D.I. (Eds). Handbook of essential fatty acid biology (1997), Humana Press, Totowa, NJ 397-426
53. Reisbick S., Neuringer M., Gohl E., Wald R., and Anderson G.J. Visual attention in infant monkeys: effects of dietary fatty acids and age. Dev Psychol 33 (1997) 387-395
54. Rice D.C. Central nervous system effects of perinatal exposure to lead or methylmercury. In: Clarkson T., Nordberg G., and Sager P. (Eds). Reproductive and developmental toxicity of metals (1983), Plenum Press, New York 517-539
55. Rice D.C. Chronic low-lead exposure from birth produces deficits in discrimination reversal in monkeys. Toxicol Appl Pharmacol 77 (1985) 201-210
56. Rice D.C. Effects of pre- plus postnatal exposure to methylmercury in the monkey on fixed interval and discrimination reversal performance. Neurotoxicology 13 (1992) 443-452
57. Rice D.C. Sensory and cognitive effects of developmental methylmercury exposure in monkeys, and a comparison to effects in rodents. Neurotoxicology 17 (1996) 139-154
58. Rice D.C., and Gilbert S.G. Early chronic low-level methylmercury poisoning in monkeys impairs spatial vision. Science 216 (1982) 759-761
59. Rice D.C., and Gilbert S.G. Effects of developmental exposure to methyl mercury on spatial and temporal visual function in monkeys. Toxicol Appl Pharmacol 102 (1990) 151-163
60. Ridley R.M., Clark B.A., Durnford L.J., and Baker H.F. Stimulus-bound perseveration after frontal ablations in marmosets. Neuroscience 52 (1993)
61. Schaefer E.J., Bongard V., Beiser A.S., Lamon-Fava S., Robins S.J., Au R., et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol 63 (2006) 1545-1550
62. Schantz S.L., and Bowman R.E. Learning in monkeys exposed perinatally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Neurotoxicol Teratol 11 (1989) 13-19
63. Schreiner G., Ulbrich B., and Bass R. Testing strategies in behavioral teratology. II. Discrimination learning. Neurobehav Toxicol Teratol 8 (1986) 567-572
64. Schultz W., Tremblay L., and Hollerman J.R. Reward processing in primate orbitofrontal cortex and basal ganglia. Cereb Cortex 10 (2000) 272-284
65. Shafer T.J., Meacham C.A., and Barone Jr. S. Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltage-sensitive sodium and calcium currents in PC12 cells. Brain Res Dev Brain Res 136 (2002) 151-164
66. Smith L.H. The pathophysiology and medical treatment of urolithiasis. Semin Nephrol 10 (1990) 31-52
67. Stern S., Cox C., Cernichiari E., Balys M., and Weiss B. Perinatal and lifetime exposure to methylmercury in the mouse: blood and brain concentrations of mercury to 26 months of age. Neurotoxicology 22 (2001) 467-477
68. Tremblay L., and Schultz W. Relative reward preference in primate orbitofrontal cortex. Nature 398 (1999) 704-708
69. Wainwright P. Essential fatty acids and behavior. In: Yehuda S., and Mostofsky D.I. (Eds). Handbook of essential fatty acid biology (1997), Humana Press, Totowa, NJ 299-341
70. Wainwright P.E., Huang Y.S., Bulman-Fleming B., Dalby D., Mills D.E., Redden P., et al. The effects of dietary n - 3/n - 6 ratio on brain development in the mouse: a dose response study with long-chain n - 3 fatty acids. Lipids 27 (1992) 98-103
71. Wainwright P.E., Xing H.C., Ward G.R., Huang Y.S., Bobik E., Auestad N., et al. Water maze performance is unaffected in artificially reared rats fed diets supplemented with arachidonic acid and docosahexaenoic acid. J Nutr 129 (1999) 1079-1089
72. Widholm J.J., Seo B.W., Strupp B.J., Seegal R.F., and Schantz S.L. Effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on spatial and visual reversal learning in rats. Neurotoxicol Teratol 25 (2003) 459-471
73. Widholm J.J., Clarkson G.B., Strupp B.J., Crofton K.M., Seegal R.F., and Schantz S.L. Spatial reversal learning in Aroclor 1254-exposed rats: Sex-specific deficits in associative ability and inhibitory control. Toxicol Appl Pharmacol 174 (2001) 188-198
74. Yamamoto N., Saitoh M., Moriuchi A., Nomura M., and Okuyama H. Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. J Lipid Res 28 (1987) 144-151
75. Yamamoto N., Hashimoto A., Takemoto Y., Okuyama H., Nomura M., Kitajima R., et al. Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions. J Lipid Res 29 (1988) 1013-1021