Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 12, 2003, Pages 1386-1398

  Masuda, Takeshi ^a   Yoshida, Shuku ^a   Arai, Masami ^a   Kaneko, Satoru ^a   Yamashita, Makoto ^a   Honda, Takeshi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Anti influenza drug; Poly L glutamine; Sialic acid; Sialidase inhibitor; Zanamivir

Indexed keywords

ANTIVIRUS AGENT; GUANIDINE DERIVATIVE; INFLUENZA VACCINE; POLYGLUTAMINE; SIALIDASE INHIBITOR; ZANAMIVIR; ENZYME INHIBITOR; PYRAN DERIVATIVE; SIALIC ACID DERIVATIVE; SIALIDASE;

ANIMAL CELL; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; INFLUENZA VIRUS A; MOUSE; NONHUMAN; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DISEASE MODEL; DOG; DRUG ANTAGONISM; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; INTRANASAL DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; ORTHOMYXOVIRUS INFECTION; SYNTHESIS;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DISEASE MODELS, ANIMAL; DOGS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FEMALE; GUANIDINES; INFLUENZA A VIRUS; MICE; MICE, INBRED BALB C; NEURAMINIDASE; ORTHOMYXOVIRIDAE INFECTIONS; PYRANS; SIALIC ACIDS; ZANAMIVIR;

EID: 3142767850     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.1386     Document Type: Article

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