Pellagra: A clue as to why energy failure causes diseases?

Medical Hypotheses

Volumn 69, Issue 3, 2007, Pages 618-628

  Williams, Adrian C ^a   Ramsden, David B ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; AUTOPHAGY; CALORIC INTAKE; CANCER; CHRONIC DISEASE; CLINICAL FEATURE; DEATH; DEMENTIA; DERMATITIS; DIARRHEA; DIET; HOMEOSTASIS; HUMAN; INFLAMMATORY DISEASE; MALARIA; METABOLIC SYNDROME X; MYCOSIS; NERVE DEGENERATION; PELLAGRA; PREMATURE AGING; PRIORITY JOURNAL; SYMBIONT; SYMPTOMATOLOGY; TUBERCULOSIS;

ANIMALS; BIOCHEMISTRY; DIET; HUMANS; INFECTION; INFLAMMATION; METABOLISM; MODELS, BIOLOGICAL; MODELS, THEORETICAL; NAD; NIACINAMIDE; NUTRITIONAL STATUS; PELLAGRA;

EID: 34447278854     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.01.029     Document Type: Article

References (77)

1. Watson T. Lectures on the principle and practice of physics. 5th ed. 1871.
2. Rolleston H. The nature of disease. Bmj 1 (1929) 281-287
3. Elvehjem C.A., Madden R.J., Strong F.M., and Wooley D.W. Relation of nicotinic acid and nicotinic acid amide to canine black tongue. JACS 59 (1937) 1767-1768
4. Spies T.D., Bean W.B., and Ashe W.F. Recent advances in the treatment of pellagra and associated deficiencies. Ann Intern Med 12 (1939) 1830-1844
5. Porter J.W.G. In: Lewis D. (Ed). Digestive physiology and nutrition of the ruminant (1961), Butterworth, London 226
6. McDowell L.R. Vitamins in animal and human nutrition (2000), Iowa State University Press, Iowa p. 347-84
7. Harris H.F. Pellagra (1919), MacMillan, New York
8. Wilson S.A.K. Neurology (1940), Edward Arnold, London p. 1359-76
9. Spillane J.D. Nutritional disorders of the nervous system (1947), E and S Livingstone, Edinburgh p. 29-47
10. Roe D.A. A Plague of corn (1973), Cornell University Press, London
11. Gillman J., and Gillman T. Perspectives in human malnutrition (1951), Grune and Stratton, New York
12. Katyal S.L., and Lombardi B. Effects of dietary choline and N,N-dimethylaminoethanol on lung phospholipids and surfactant of newborn rats. Pediat Res 12 (1978) 952-955
13. Lombroso U. Studi clinica ed experimentale sulla natura, causa, della Pellagra. Rev Clin di Bologna 8 (1869) 289-321
14. Jolliffe N., Bowman K.M., Rosenblum L.A., and Fein H.D. Nicotinic acid deficiency encephalopathy. JAMA 114 (1940) 307-310
15. Vallat J.N., Lepetit J.M., Demarti D., and Boutet P. Accidents neurologiques de la pellagre. La Presse Medicale 13 (1962) 625-627
16. Pellise A., Navarro O., Rey M., et al. Protein 14.3.3 in pellagra encephalopathy. Neurologia 17 (2002) 654-656
17. Lussana F. Su la Pellagra (1856), Guiseppe Benardoni, Milano
18. Paravicini P. Pellagra e morbo di Parkinson. Riv Pel Ital (1912) 109-113
19. Berg J.M., Tymocko J.L., and Styer L. Biochemistry. 6th ed. (2006), WH Freeman & Co, New York p. 502-540
20. Abdoul-Carime H., Gohlke S., and Illinberger E. Site-specific dissociation of DNA bases by slow electrons at early stages of irradiation. Phys Rev Lett 92 (2004) 1681031-1681034
21. Kadenbach B. Intrinsic and extrinsic uncoupling of oxidative phosphorylation. Biochim Biophys Acta 1604 (2003) 77-94
22. Testa C.M., Sherer T.B., and Greenamyre J.T. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res Mol Brain Res 134 (2005) 109-118
23. Pearson P.B., Perlzweig W.A., and Rosen F. The metabolism of niacin in ruminants. F Arch Biochem 9 (1949) 191-194
24. Cantoni G.L. Methylation of nicotinamide with a soluble enzyme system from rat liver. J Biol Chem 189 (1951) 203-216
25. Parsons R.B., Smith M.-L., Williams A.C., et al. Expression of nicotinamide N-methyltransferase (EC. 2.1.1.1) in the Parkinsonian brain. J Neuropath Exp Neurol 61 (2002) 111-124
26. Vargas H.M., and Jenden D.J. Elevation of cerebrospinal fluid choline levels by nicotinamide involves the enzymatic formation of N-methyl nicotinamide in brain tissue. Life Sci 58 (1996) 1995-2002
27. Blusztajyn J.K. Choline a vital amine. Science 281 (1998) 794-795
28. Williams A.C., Cartright L.S., and Ramsden D.B. Parkinson's disease; the first common neurological disease due to auto-intoxication?. Q J Med 98 (2005) 215-226
29. Erb C., and Klein J. Enhancement of brain choline levels by nicotinamide: mechanism of action. Neurosci Lett 249 (1998) 111-114
30. Emmanuel B., and Kennelly J.J. Kinetics of methionine and choline and their incorporation into plasma lipids and milk components in lactating goats. J Dairy Sci 67 (1984) 1912-1918
31. Kaplan N.O., Goldin A., Humphreys S.R., et al. Pyridine nucleotide synthesis in the mouse. J Biol Chem 219 (1956) 287-298
32. Burton R.M., Kaplan N.O., and Goldin A. Effect of reserpine and promazine on diphosphopyridine nucleotide synthesis in liver. Science 127 (1958) 31-32
33. Fratta I., Zak S.B., Greengard P., and Sigg E.B. Fetal death from nicotinamide deficient diet and its prevention by chlorpromazine and imipramine. Science 145 (1964) 1429-1430
34. Munn D.H., Sharma M.D., Lee J.R., et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297 (2002) 1867-1870
35. Moffett J.R., and Namboodiri M.A.A. Tryptophan and the immune response. Immunol Cell Biol 81 (2003) 247-265
36. Grohmann U., Fallarino F., and Puccetti P. Tolerance, DCs and tryptophan; much ado about IDO. Trends Immunol 24 (2003) 242-249
37. Taylor M.W., and Feng G. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. Faseb J 5 (1991) 2516-2522
38. Wijnholds J., Mol C.A., van Deemter L., et al. Multidrug-resistance protein 5 is a multispecific organ ion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 97 (2000) 7476-7481
39. Chorine V. Action de l'amide nicotinique sur les bacilles du genre mycobacterium. Compt Rendu Acad Sci 220 (1945) 150-152
40. Hinshaw H.C., and McDermott W. Thiosemicarbazone therapy of tuberculosis in humans. Amer Rev Tuberc 61 (1950) 145-157
41. Yates S.P., Jorgensen G.R., Andersen G.R., and Merrill A.R. Stealth and mimicry by deadly bacterial toxins. Trends Biochem Sci 31 (2006) 123-133
42. Maiese K., and Chong Z.Z. Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol Sci 24 (2003) 228-232 39pp
43. D'Amours D., Desnoyers S., D'Silva I., and Poirier G.G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 342 (1999) 249-268
44. Bedalov A., and Simon J.A. NAD to the rescue. Science 305 (2004) 954-955
45. Feng Y., Paul I.A., and LeBlanc M.H. Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat. Brain Res Bull 69 (2006) 117-122
46. Koppen A., Klein J., Holler T., and Loffelholz K. Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain. J Pharmacol Exp Ther 266 (1993) 720-725
47. Handler P., and Dann W.J. The inhibition of rat growth by nicotinamide. J Biol Chem 142 (1942) 357-368
48. Dogan S., Deshpande D.A., White T.A., Walseth T.F., and Kannan M.S. Regulation of CD 38 expression and function by steroid hormones in myometrium. Mol Cellular Endocrinol 246 (2006) 101-106
49. Chiarugi A., and Moskowitz M.A. Poly (ADP-ribose)polymerase-1 activity promotes NK-Kb-driven transcription and microglial activation: implication for neurodegenerative disease. J Neurochem 85 (2003) 306-317
50. Hockly E., Richon V.M., and Woodman B. Suberoylanilidine hydroxamic acid, a histone deacetylase inhibitor ameliorates motor deficits in a mouse model of Huntington's disease. Proc Nat Acad Sci USA 100 (2003) 2041-2046
51. Marecki J.C., and McCord J.M. The inhibition of poly (ADP-ribose) polymerase enhances growth rate of ataxia telangiectasia cells. Arch Biochem Biophys 402 (2002) 227-234
52. Bardoe L., and Guarente L. Calorie restriction, SIRT1 and metabolism, understanding longevity. Nature Rev Mol Cell Biol 126 (2005) 787-1002
53. Araki T., Sasaki Y., and Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305 (2004) 1010-1013
54. McKeown T. The origins of human disease (1988), Blackwell, Oxford p. 91-233
55. Hirano A., Kurland L.T., Krooth R.S., and Lessell S. Parkinsonism-dementia complex, an endemic disease on the island of Guam. Brain 84 (1961) 642-661
56. Sachs O. Cycad Island. The island of the color blind (1998), Vintage, New York 109-201
57. Ince P.G., and Codd G.A. Return of the cycad hypothesis-does the amyotrophic lateral sclerosis parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?. Neuropathol Appl Neurobiol 31 (2005) 345-353
58. Lannuzel A., Michel P.P., Caparros-Lefebvre D., et al. Toxicity of annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in guadeloupe. Mov Dis 17 (2002) 84-90
59. Ip C., Thompson H.J., Zhu Z., and Ganther H.E. In vivo and in vitro studies of methyl seleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Cancer Res 60 (2000) 2882-2886
60. Morris M.C., Evans D.A., Bienias J.L., et al. Dietary niacin and the risk of incident Alzheimer's disease and a cognitive decline. J Neurol Neurosurg Psychiat 75 (2004) 1093-1099
61. Sultana R., Newman S.F., Abdul H.M., Cai J., Pierce W.M., Klein J.B., et al. Protective effect of D609 against amyloid-beta1-42-induced oxidative modification of neuronal proteins: redox proteomics study. J Neurosci Res 84 (2006) 409-417
62. Clippingdale A.B., Wade J.D., and Barrow C.J. The amyloid-B peptide and it's role in Alzheimer's disease. J Peptide Sci 7 (2001) 227-249
63. Price R.W. Neurological complications of HIV infection. Lancet 348 (1996) 445-452
64. Weissman D., Rubbert A., and Combadiere C. Dendritic cells express and use multiple coreceptors. Adv Exp Med Biol 417 (1997) 401-406
65. Keating J.N., Trimble K.C., Mulcahy F., et al. Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients. Lancet 337 (1991) 935-939
66. Murray M.F. Tryptophan depletion and HIV infection: a metabolic link to pathogenesis. Lancet Inf Dis 3 (2003) 644-652
67. Kameoka M., Nukuzuma S., Itaya A., et al. Poly(ADP-ribose)polymerase-1 is required for integration of the human immunodeficiency virus type 1 genome near centromeric alphoid DNA in human and murine cells. Biochem Biophys Res Commun 334 (2005) 412-417
68. Li T.-K., Barbieri C.M., Lin H.-C., et al. Drug targeting of HIV-1 RNA-DNA Hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication. Biochemistry 43 (2004) 9732-9742
69. Beck M.A., Handy J., and Levander O.A. Host nutritional status: the neglected virulence factor. Trends Microbiol 12 (2004) 417-423
70. Pasteur M. Observations relatives a la Note precedente de M Duclaux. Comp Rendu Acad Sci 100 (1885) 68
71. Cohendy M. Experiences sur la vie sans microbes. Ann Inst Pasteur 26 (1912) 106-137
72. Luckey T.D. Germ free life and gnotobiology (1963), Academic Press, London p. 15-45
73. Dubos R. Symbiosis between the earth and humankind. Science 193 (1976) 459-462
74. Williams A., and Ramsden D. Nicotinamide: a double-edged sword. Parkinsonism Relat Disord 11 (2005) 413-420
75. Ritsick D.R., and Lambeth D.J. Spring brings breezes, wheezes, and pollen oxidases. J Clin Invest 115 (2005) 2067-2069
76. Charron M.J., and Bonner-Weir S. Implicating PARP and NAD depletion in Type 1 diabetes. Nature Med 5 (1999) 269-270
77. Ashcroft F.M. K (ATP) channels and insulin secretion: a key role in health and disease. Biochem Soc Trans 34 (2006) 243-246